PGE2 is essential for gap junction-mediated Intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain

Endocrinology

Volumn 142, Issue 8, 2001, Pages 3464-3473

  Cheng, Benxu ^a   Kato, Yoichi ^c   Zhao, Shujie ^a   Luo, Jian ^b   Sprague, Eugene ^b   Bonewald, Lynda F ^a   Jiang, Jean X ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c ASAHI CHEMICAL INDUSTRY CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; PROSTAGLANDIN E2;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL COMMUNICATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME INHIBITION; FLOW KINETICS; FLUID FLOW; GAP JUNCTION; MECHANICAL STRESS; MEDIATOR RELEASE; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; RAT;

EID: 0034922723     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.8.8338     Document Type: Article

References (60)

1. Cell mobility and tissue morphogenesis
2. Candidates for the mechanosensory system in bone
3. Function of osteocytes in bone
4. Sensitivity of osteocytes to biomechanical stress in vitro
5. Pulsating fluid flow increases PG production by cultured chicken osteocytes-a cytoskeleton-dependent process
6. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production
7. A model for the excitation of osteocytes by mechanical loading induced bone fluid shear stresses
8. Mechanotransduction in bone: Do bone cells act as sensors of fluid flow?
9. Morphological evidence of gap junctions between bone cells
10. Morphological study of intercellular junctions during osteocyte differentiation
11. Gap junctions, electronic coupling, and intercellular communication
12. Connexin mutations in X-linked Charcot-Marie-Tooth disease
13. Mutations of the connexin43 gap-junction gene in patients with heart malformations and defects of laterality
14. Cardiac malformation in neonatal mice lacking connexin43
15. Female infertility in mice lacking connexin37
16. Connexin 26 mutations in hereditary non-syndromic sensorineural deafness
17. 3 connexin gene leads to proteolysis and cataractogenesis in mice
18. Molecular and functional characterization of lens fibers connexins
19. Connexin43: A protein from rat heart homologous to a gap junction protein from liver
20. The connexins, a family of related gap junction proteins
21. Establishment of an osteocyte-like cell line, MLO-Y4
22. Expression of the osteocyte-specific antigen, E11, in MLO-Y4 cells and mineralizing osteoblasts
23. Functional gap junctions between osteocytic and osteoblastic cells
24. Expression of functional gap junctions and regulation by fluid flow shear stress in osteocyte-like MLO-Y4 cells
25. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells
26. 2 and inositol trisphosphate levels in osteoblasts
27. Evidence that the mitogenic effect of prostaglandin E2 on human bone cells involves protein kinase C and calcium pathways
28. 2 on fracture callus in rabbit
29. The effects of prostaglandin E2 in growing rats: Increased metaphyseal hard tissue and corticoendosteal bone formation
30. Effects of prostaglandin E2 on bone formation in cultured fetal calvariae: Role of insulin-like growth factor-1
31. 2
32. Effect of prostaglandin E2 on mineralization of bone noodles formed by fetal rat calvarial cells
33. Prostaglandins in bone and mineral metabolism
34. Biphasic effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: Interaction with cortisol
35. Effect of prostaglandins E1, E2, and F2α on osteoclast formation in mouse bone marrow cultures
36. Prostaglandin E2 promotes osteoclast formation in murine hematopietic cultures through an action on hematopoietic cells
37. Prostaglandin E2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoclasts: Role of cAMP-dependent protein kinase
38. Prostaglandin E2 enhances cortical bone mass and activates intracorticaI bone remodeling in intact and ovariectomized female rats
39. Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells
40. Flow-related responses of intracellular inositol phosphate levels in cultured aortic endothelial cells
41. A method for incorporating macromolecules into adherent cells
42. Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70
43. Formation of heteromeric gap junction channels by connexin 40 and 43 in vascular smooth muscle cells
44. Regulation of prostaglandin synthase-1 and prostaglandin synthase-2
45. Prostanoid biosynthesis and mechanisms of action
46. 2 production in osteoblasts
47. Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins
48. Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways
49. Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts-correlation with prostaglandin up-regulation
50. Role of nitric oxide and prostaglandins in mechanically induced bone formation
51. Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo
52. Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation
53. Indomethacin modulation of load-related stimulation of new bone formation in vivo
54. 2 increases dhe skeletal response to mechanical loading
55. Classification of prostaglandin receptors based on coupling or signaling transduction systems
56. Prostaglandin-stimulated second message signaling in bone-derived endothelial cells is dependent on confluency in culture
57. +/camodulin
58. 2 on phospholiase D activity in osteoblast-like MC3T3-E1 cells
59. 2 stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: Involvement in sustained 1,2-diacylglycerol production
60. Connexins, connexons, and intercellelar communication