-
2
-
-
0027319521
-
P53 is required for radiation-induced apoptosis in mouse thymocytes
-
S. Lowe, E. Schmitt, S. Smith, B. Osborne and T. Jacks p53 is required for radiation-induced apoptosis in mouse thymocytes Nature (Lond.) 362 1993 847 849
-
(1993)
Nature (Lond.)
, vol.362
, pp. 847-849
-
-
Lowe, S.1
Schmitt, E.2
Smith, S.3
Osborne, B.4
Jacks, T.5
-
3
-
-
0028786276
-
The Janus protein tyrosine kinase family and its role in cytokine signaling
-
J.N. Ihle The Janus protein tyrosine kinase family and its role in cytokine signaling Adv. Immunol. 60 1995 1 35
-
(1995)
Adv. Immunol.
, vol.60
, pp. 1-35
-
-
Ihle, J.N.1
-
4
-
-
0028209870
-
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130
-
M. Narazaki, B. Witthuhn, K. Yoshida, O. Silvennoinen, K. Yasukawa, J. Ihle, T. Kishinito and T. Taga Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130 Proc. Natl. Acad. Sci. USA 91 1994 2285 2289
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 2285-2289
-
-
Narazaki, M.1
Witthuhn, B.2
Yoshida, K.3
Silvennoinen, O.4
Yasukawa, K.5
Ihle, J.6
Kishinito, T.7
Taga, T.8
-
5
-
-
0035799531
-
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
-
R. Garcia, T. Bowman, G. Niu, H. Yu, S. Minton, C. Muro-Cacho, C.E. Cox, R. Falcone, R. Fairclough, S. Parsons, A. Laudano, A. Gazit, A. Levitzki and A. Kraker Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells Oncogene 20 2002 2499 2513
-
(2002)
Oncogene
, vol.20
, pp. 2499-2513
-
-
Garcia, R.1
Bowman, T.2
Niu, G.3
Yu, H.4
Minton, S.5
Muro-Cacho, C.6
Cox, C.E.7
Falcone, R.8
Fairclough, R.9
Parsons, S.10
Laudano, A.11
Gazit, A.12
Levitzki, A.13
Kraker, A.14
-
7
-
-
0031443156
-
Constitutive activation of Stat 3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
-
R. Garcia, C. Yu, A. Hudnall, R. Catlett, K. Nelson, T. Smithgall, D.J. Fujita, S.D. Ethier and R. Jove Constitutive activation of Stat 3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells Cell Growth Differ. 8 1997 1267 1275
-
(1997)
Cell Growth Differ.
, vol.8
, pp. 1267-1275
-
-
Garcia, R.1
Yu, C.2
Hudnall, A.3
Catlett, R.4
Nelson, K.5
Smithgall, T.6
Fujita, D.J.7
Ethier, S.D.8
Jove, R.9
-
8
-
-
0037384714
-
Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells
-
H. Ruchatz, A. Coluccia, P. Stano, E. Marchesi and C. Gambacorti-Passerini Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells Exp. Hematol. 31 2003 309 315
-
(2003)
Exp. Hematol.
, vol.31
, pp. 309-315
-
-
Ruchatz, H.1
Coluccia, A.2
Stano, P.3
Marchesi, E.4
Gambacorti-Passerini, C.5
-
9
-
-
0034653478
-
Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells
-
V. Lacronique, A. Boureux, R. Monni, S. Dumon, M. Mauchauffe, P. Mayeux, F. Gouilleux, R. Berger, S. Gisselbretch, J. Ghysdael and O.A. Bernard Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells Blood 95 2000 2076 2083
-
(2000)
Blood
, vol.95
, pp. 2076-2083
-
-
Lacronique, V.1
Boureux, A.2
Monni, R.3
Dumon, S.4
Mauchauffe, M.5
Mayeux, P.6
Gouilleux, F.7
Berger, R.8
Gisselbretch, S.9
Ghysdael, J.10
Bernard, O.A.11
-
10
-
-
0034660270
-
TEL-JAK2 transgenic mice develop T-cell leukemia
-
C. Carron, F. Cormier, A. Janin, V. Lacronique, M. Giovannini, M.T. Daniel, O. Bernard and J. Ghysdael TEL-JAK2 transgenic mice develop T-cell leukemia Blood 95 2000 3891 3899
-
(2000)
Blood
, vol.95
, pp. 3891-3899
-
-
Carron, C.1
Cormier, F.2
Janin, A.3
Lacronique, V.4
Giovannini, M.5
Daniel, M.T.6
Bernard, O.7
Ghysdael, J.8
-
11
-
-
0033525525
-
Constitutive activation of JAK2 confers murine interleukin-3-independent survival and proliferation of BA/F3 cells
-
C. Liu, T. Itoh, K. Arai and S. Watanabe Constitutive activation of JAK2 confers murine interleukin-3-independent survival and proliferation of BA/F3 cells J. Biol. Chem. 274 1999 6342 6349
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6342-6349
-
-
Liu, C.1
Itoh, T.2
Arai, K.3
Watanabe, S.4
-
12
-
-
0033120870
-
Constitutive activation of the JAK2/Stat5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell line
-
R. Liu, C. Fan, R. Garcia, R. Jove and K. Zuckerman Constitutive activation of the JAK2/Stat5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell line Blood 93 1999 2369 2379
-
(1999)
Blood
, vol.93
, pp. 2369-2379
-
-
Liu, R.1
Fan, C.2
Garcia, R.3
Jove, R.4
Zuckerman, K.5
-
13
-
-
0035042611
-
SOCS-1, a negative regulator of the JAK/Stat pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
-
H. Yoshikawa, K. Matsubara, G. Qian, P. Jackson, J. Groopman, J. Manning, C.C. Harris and J.G. Herman SOCS-1, a negative regulator of the JAK/Stat pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity Nat. Genet. 28 2001 29 35
-
(2001)
Nat. Genet.
, vol.28
, pp. 29-35
-
-
Yoshikawa, H.1
Matsubara, K.2
Qian, G.3
Jackson, P.4
Groopman, J.5
Manning, J.6
Harris, C.C.7
Herman, J.G.8
-
14
-
-
85047699773
-
P53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3
-
J. Lin, H. Tang, X. Jin, G. Jia and J. Hsieh p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3 Oncogene 21 2002 3082 3088
-
(2002)
Oncogene
, vol.21
, pp. 3082-3088
-
-
Lin, J.1
Tang, H.2
Jin, X.3
Jia, G.4
Hsieh, J.5
-
15
-
-
0037081296
-
Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells
-
J. Lin, X. Jin, K. Rothman, H. Lin, H. Tang and W. Burke Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells Cancer Res. 62 2002 376 380
-
(2002)
Cancer Res.
, vol.62
, pp. 376-380
-
-
Lin, J.1
Jin, X.2
Rothman, K.3
Lin, H.4
Tang, H.5
Burke, W.6
-
16
-
-
0031053810
-
Proteasome- and p53-dependent masking of signal transducer and activator of transcription (Stat) factors
-
R. Rayanade, K. Patel, M. Ndubuisi, S. Sharma, S. Omura, J.D. Etlinger, R. Pine and P.B. Sehgal Proteasome- and p53-dependent masking of signal transducer and activator of transcription (Stat) factors J. Biol. Chem. 272 1997 4659 4662
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4659-4662
-
-
Rayanade, R.1
Patel, K.2
Ndubuisi, M.3
Sharma, S.4
Omura, S.5
Etlinger, J.D.6
Pine, R.7
Sehgal, P.B.8
-
17
-
-
0031859080
-
Regulation of IL-6 signaling by p53: Stat3- and Stat5-masking in p53-Val135-containing human hepatoma Hep3B cell lines
-
R. Rayanade, M. Ndubuisi, J. Etlinger and P. Sehgal Regulation of IL-6 signaling by p53: Stat3- and Stat5-masking in p53-Val135-containing human hepatoma Hep3B cell lines J. Immunol. 161 1998 325 334
-
(1998)
J. Immunol.
, vol.161
, pp. 325-334
-
-
Rayanade, R.1
Ndubuisi, M.2
Etlinger, J.3
Sehgal, P.4
-
18
-
-
0028303752
-
Several hydrophobic amino acids in the p53 N-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55kd protein
-
J. Lin, J. Chen, B. Elenbaas and A.J. Levine Several hydrophobic amino acids in the p53 N-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55kd protein Genes Dev. 8 1994 1235 1246
-
(1994)
Genes Dev.
, vol.8
, pp. 1235-1246
-
-
Lin, J.1
Chen, J.2
Elenbaas, B.3
Levine, A.J.4
-
19
-
-
0036254630
-
Resistance to p53-mediated growth suppression in human ovarian cancer cells retained endogenous wild-type p53
-
X. Jin, W. Burke, K. Rothman and J. Lin Resistance to p53-mediated growth suppression in human ovarian cancer cells retained endogenous wild-type p53 Anticancer Res. 22 2002 659 664
-
(2002)
Anticancer Res.
, vol.22
, pp. 659-664
-
-
Jin, X.1
Burke, W.2
Rothman, K.3
Lin, J.4
-
20
-
-
15444339209
-
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
-
V. Lacronique, A. Boureux, V. Valle, H. Poirel, C. Quang, M. Mauchauffe, C. Berthou, M. Lessard, R. Berger, J. Ghysdael and O.A. Bernard A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia Science 278 1997 1309 1312
-
(1997)
Science
, vol.278
, pp. 1309-1312
-
-
Lacronique, V.1
Boureux, A.2
Valle, V.3
Poirel, H.4
Quang, C.5
Mauchauffe, M.6
Berthou, C.7
Lessard, M.8
Berger, R.9
Ghysdael, J.10
Bernard, O.A.11
-
21
-
-
0027210981
-
Gain of function mutations in p53
-
D. Dittmer, S. Pati, G. Zambetti, S. Chu, A. Teresky, M. Moore, C. Finlay and A.J. Levine Gain of function mutations in p53 Nat. Genet. 4 1993 42 46
-
(1993)
Nat. Genet.
, vol.4
, pp. 42-46
-
-
Dittmer, D.1
Pati, S.2
Zambetti, G.3
Chu, S.4
Teresky, A.5
Moore, M.6
Finlay, C.7
Levine, A.J.8
-
22
-
-
0032574788
-
An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control
-
A. Gualberto, K. Aldape, K. Kozakiewicz and T. Tlsty An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control Proc. Natl. Acad. Sci. USA 95 1998 5166 5171
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 5166-5171
-
-
Gualberto, A.1
Aldape, K.2
Kozakiewicz, K.3
Tlsty, T.4
-
23
-
-
0035930501
-
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
-
M. Myers, J. Andersen, A. Cheng, M. Tremblay, C. Horvath, J. Parisien, A. Salmeen, D. Barford and N.K. Torks TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B J. Biol. Chem. 276 2001 47771 47774
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47771-47774
-
-
Myers, M.1
Andersen, J.2
Cheng, A.3
Tremblay, M.4
Horvath, C.5
Parisien, J.6
Salmeen, A.7
Barford, D.8
Torks, N.K.9
-
24
-
-
0037201559
-
Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line
-
W. Kaszubska, H. Falls, V. Schaefer, D. Haasch, L. Frost, P. Hessler, P.E. Kroeger, D.W. White, M.R. Jirousek and J.M. Trevillyan Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line Mol. Cell. Endocrinol. 195 2002 109 118
-
(2002)
Mol. Cell. Endocrinol.
, vol.195
, pp. 109-118
-
-
Kaszubska, W.1
Falls, H.2
Schaefer, V.3
Haasch, D.4
Frost, L.5
Hessler, P.6
Kroeger, P.E.7
White, D.W.8
Jirousek, M.R.9
Trevillyan, J.M.10
-
25
-
-
0035918239
-
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
-
S. Kamizono, T. Hanada, H. Yasukawa, S. Minoguchi, R. Kato, M. Minoguchi, K. Hattori, S. Hatakeyama, M. Yada, S. Morita, T. Kitamura, H. Kato, Ki Nakayama and A. Yoshimura The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2 J. Biol. Chem. 276 2001 12530 12538
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12530-12538
-
-
Kamizono, S.1
Hanada, T.2
Yasukawa, H.3
Minoguchi, S.4
Kato, R.5
Minoguchi, M.6
Hattori, K.7
Hatakeyama, S.8
Yada, M.9
Morita, S.10
Kitamura, T.11
Kato, H.12
Ki, N.13
Yoshimura, A.14
-
26
-
-
0034726958
-
The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-Stat activation
-
T. Iwamoto, T. Senga, Y. Naito, S. Matsuda, Y. Miyake, A. Yoshimura and M. Hamaguchi The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-Stat activation Oncogene 19 2000 4795 4801
-
(2000)
Oncogene
, vol.19
, pp. 4795-4801
-
-
Iwamoto, T.1
Senga, T.2
Naito, Y.3
Matsuda, S.4
Miyake, Y.5
Yoshimura, A.6
Hamaguchi, M.7
-
27
-
-
85047698100
-
Inhibition of constitutively active Stat3 in ovarian and breast cancer cells
-
M.W. Burke, X. Jin, H. Lin, M. Huang, R. Liu, K. Reynolds and J. Lin Inhibition of constitutively active Stat3 in ovarian and breast cancer cells Oncogene 20 2001 7925 7934
-
(2001)
Oncogene
, vol.20
, pp. 7925-7934
-
-
Burke, M.W.1
Jin, X.2
Lin, H.3
Huang, M.4
Liu, R.5
Reynolds, K.6
Lin, J.7
-
28
-
-
0035971921
-
Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-included prolongation of rat eosinophil survival
-
K. Ishihara, I. Satoh, S. Mue and K. Ohuchi Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-included prolongation of rat eosinophil survival Biochim. Biophys. Acta 1536 2001 73 84
-
(2001)
Biochim. Biophys. Acta
, vol.1536
, pp. 73-84
-
-
Ishihara, K.1
Satoh, I.2
Mue, S.3
Ohuchi, K.4
-
29
-
-
0033861096
-
JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (Stat) pathways and induces apoptosis myelome cells
-
J. De Vos, M. Jourdan, K. Tarte, C. Jasmin and B. Klein JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (Stat) pathways and induces apoptosis myelome cells Br. J. Haematol. 109 2000 823 828
-
(2000)
Br. J. Haematol.
, vol.109
, pp. 823-828
-
-
De Vos, J.1
Jourdan, M.2
Tarte, K.3
Jasmin, C.4
Klein, B.5
-
30
-
-
0032934674
-
Involvement of JAK2, but not PI 3-kiinase/Akt and MAP kinase pathways, in anti-apoptotic signals if GM-CSF in human eosinophils
-
S. Miike, A. Nakao, M. Hiraguri, K. Kurasawa, Y. Saito and I. Iwamoto Involvement of JAK2, but not PI 3-kiinase/Akt and MAP kinase pathways, in anti-apoptotic signals if GM-CSF in human eosinophils J. Leukoc. Biol. 65 1999 700 706
-
(1999)
J. Leukoc. Biol.
, vol.65
, pp. 700-706
-
-
Miike, S.1
Nakao, A.2
Hiraguri, M.3
Kurasawa, K.4
Saito, Y.5
Iwamoto, I.6
-
31
-
-
0031472685
-
Anti-apoptotic signal of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophhils
-
H.U. Simon, S. Yousefi, B. Dibbert, F. Levi-schaffer and K. Blaser Anti-apoptotic signal of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophhils Eur. J. Immunol. 27 1997 3536 3539
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 3536-3539
-
-
Simon, H.U.1
Yousefi, S.2
Dibbert, B.3
Levi-Schaffer, F.4
Blaser, K.5
-
32
-
-
0030953788
-
The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells
-
I. Sakai and A.S. Kraft The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells J. Biol. Chem. 272 1997 12350 12358
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 12350-12358
-
-
Sakai, I.1
Kraft, A.S.2
-
33
-
-
0035799531
-
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
-
R. Garcia, T.L. Bowman, G. Niu, H. Yu, S. Minton, C.A. Muro-Cacho, C.E. Cox, R. Falcone, R. Fairclough, S. Parsons, A. Laudano, A. Gazit, A. Levitzki, A. Kraker and R. Jove Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells Oncogene 20 2001 2499 2513
-
(2001)
Oncogene
, vol.20
, pp. 2499-2513
-
-
Garcia, R.1
Bowman, T.L.2
Niu, G.3
Yu, H.4
Minton, S.5
Muro-Cacho, C.A.6
Cox, C.E.7
Falcone, R.8
Fairclough, R.9
Parsons, S.10
Laudano, A.11
Gazit, A.12
Levitzki, A.13
Kraker, A.14
Jove, R.15
|