메뉴 건너뛰기




Volumn 11, Issue 2, 2004, Pages 407-414

In vitro study of farnesyltransferase inhibitor SCH 66336, in combination with chemotherapy and radiation, in non-small cell lung cancer cell lines

Author keywords

Combined therapy; K ras; Pre clinical investigation; Pulmonary neoplasia

Indexed keywords

ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; LONAFARNIB; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; TRANSFERASE;

EID: 3242803823     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.11.2.407     Document Type: Article
Times cited : (17)

References (40)
  • 1
    • 0023898932 scopus 로고
    • The ras family and human carcinogenesis
    • Bos JL: The ras family and human carcinogenesis. Mutat Res 195: 255-271, 1988.
    • (1988) Mutat Res , vol.195 , pp. 255-271
    • Bos, J.L.1
  • 2
    • 0029022018 scopus 로고
    • Mutations of ras genes in human tumours
    • Review
    • Kiaris H and Spandidos DA: Mutations of ras genes in human tumours (Review). Int J Oncol 7: 413-421, 1995.
    • (1995) Int J Oncol , vol.7 , pp. 413-421
    • Kiaris, H.1    Spandidos, D.A.2
  • 3
    • 0026735063 scopus 로고
    • Protein isoprenylation and methylation at carboxylterminal cysteine residues
    • Clarke S: Protein isoprenylation and methylation at carboxylterminal cysteine residues. Ann Rev Biochem 61: 355-386, 1992.
    • (1992) Ann Rev Biochem , vol.61 , pp. 355-386
    • Clarke, S.1
  • 4
    • 0026747866 scopus 로고
    • Isoprenoid addition to ras protein is the critical modification for its membrane association and transforming activity
    • Kato K, Cox AD, Hisaka MM, Graham SM, Buss JE and Der CJ: Isoprenoid addition to ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci USA 89: 6403, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6403
    • Kato, K.1    Cox, A.D.2    Hisaka, M.M.3    Graham, S.M.4    Buss, J.E.5    Der, C.J.6
  • 5
    • 0034050541 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: Antineoplastic mechanism and clinical prospects
    • Prendergast GC: Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects. Curr Opin Cell Biol 12: 166-173, 2000.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 166-173
    • Prendergast, G.C.1
  • 6
    • 0030916369 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors alter the prenylation and growth- stimulating function of RhoB
    • DOI 10.1074/jbc.272.25.15591
    • Lebowitz PF, Casey PJ, Prendergast GC and Thissen JA: Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. J Biol Chem 272: 15591-15594, 1997. (Pubitemid 27265524)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.25 , pp. 15591-15594
    • Lebowitz, P.F.1    Casey, P.J.2    Prendergast, G.C.3    Thissen, J.A.4
  • 7
    • 0032541625 scopus 로고    scopus 로고
    • Non-Ras targets of farnesyltransferase inhibitors: Focus on Rho
    • Lebowitz PF and Prendergast GC: Non-ras targets of farnesyltransferase inhibitors: focus on Rho. Oncogene 17: 1439-1445, 1998. (Pubitemid 28458411)
    • (1998) Oncogene , vol.17 , Issue.11 REV. ISS. 1 , pp. 1439-1445
    • Lebowitz, P.F.1    Prendergast, G.C.2
  • 8
    • 0034905234 scopus 로고    scopus 로고
    • Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines
    • Adjei AA, Davis JN, Bruzek LM, Erlichman C and Kaufmann SH: Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines. Clin Cancer Res 7: 1438-1445, 2001. (Pubitemid 32708700)
    • (2001) Clinical Cancer Research , vol.7 , Issue.5 , pp. 1438-1445
    • Adjei, A.A.1    Davis, J.N.2    Bruzek, L.M.3    Erlichman, C.4    Kaufmann, S.H.5
  • 9
    • 0033729718 scopus 로고    scopus 로고
    • The farnesyl protein transferase inhibitor SCH66336 synergizes with taxanes in vitro and enhances their antitumor activity in vivo
    • Shi B, Yaremko B, Hajian G, Terracina G, Bishop WR, Liu M and Nielsen LL: The farnesyl protein transferase inhibitor SCH66336 synergizes with taxanes in vitro and enhances their antitumor activity in vivo. Cancer Chemother Pharmacol 46: 387-393, 2000.
    • (2000) Cancer Chemother Pharmacol , vol.46 , pp. 387-393
    • Shi, B.1    Yaremko, B.2    Hajian, G.3    Terracina, G.4    Bishop, W.R.5    Liu, M.6    Nielsen, L.L.7
  • 10
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
    • Rowinsky EK, Windle JJ and von Hoff DD: Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development. J Clin Oncol 17: 3631-3652, 1999. (Pubitemid 29517936)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.11 , pp. 3631-3652
    • Rowinsky, E.K.1    Windle, J.J.2    Von Hoff, D.D.3
  • 12
    • 0029023145 scopus 로고
    • Ras CAAX peptidomimetic FTI 276 selectively blocks tumour growth in nude mice in a human lung carcinoma with K-ras mutation and p53 deletion
    • Sun J, Quian Y, Hamilton AD and Sebti SM: Ras CAAX peptidomimetic FTI 276 selectively blocks tumour growth in nude mice in a human lung carcinoma with K-ras mutation and p53 deletion. Cancer Res 55: 4243-4247, 1995.
    • (1995) Cancer Res , vol.55 , pp. 4243-4247
    • Sun, J.1    Quian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 15
    • 0023130372 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
    • Carmichael J, De Graff WJ, Gazdar AF, Minna JD and Mitchell JB: Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47: 936-942, 1987. (Pubitemid 17027905)
    • (1987) Cancer Research , vol.47 , Issue.4 , pp. 936-942
    • Carmichael, J.1    DeGraff, W.G.2    Gazdar, A.F.3
  • 16
    • 0001458215 scopus 로고
    • Effect of more than one inhibitor
    • Academic Press, NY
    • Webb JL: Effect of more than one inhibitor. In: Enzymes and Metabolic Inhibitors, volume 1. Academic Press, NY, p66, 1963.
    • (1963) Enzymes and Metabolic Inhibitors , vol.1 , pp. 66
    • Webb, J.L.1
  • 17
    • 0023945379 scopus 로고
    • In vitro pharmacodynamics of 1-beta-D-arabinofuranosylcytosine: Synergy of antitumor activity with cis-diamminedichloroplatinum(II)
    • Kern DH, Morgan CR and Hildebrand-Zanki SU: In vitro pharmacodynamics of 1-beta-D-arabinofuranosylcytosine: synergy of antitumor activity with diaminedichloroplatinum(II). Cancer Res 48: 117-121, 1988. (Pubitemid 18030339)
    • (1988) Cancer Research , vol.48 , Issue.1 , pp. 117-121
    • Kern, D.H.1    Morgan, C.R.2    Hildebrand-Zanki, S.U.3
  • 18
    • 0033794603 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors. Current developments and future perspectives
    • Eskens FALM, Stoter G and Verweij J: Farnesyl transferase inhibitors. Current developments and future perspectives. Cancer Treat Rev 26: 319-332, 2000.
    • (2000) Cancer Treat Rev , vol.26 , pp. 319-332
    • Eskens, F.A.L.M.1    Stoter, G.2    Verweij, J.3
  • 19
    • 0028331587 scopus 로고
    • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
    • DOI 10.1016/0092-8674(94)90308-5
    • Gibbs JB, Oliff A and Kohl NE: Farnesyltransferase inhibitors: ras research yields a potential cancer therapeutic. Cell 77: 175-178, 1994. (Pubitemid 24138615)
    • (1994) Cell , vol.77 , Issue.2 , pp. 175-178
    • Gibbs, J.B.1    Oliff, A.2    Kohl, N.E.3
  • 20
    • 0035844247 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
    • Crespo NC, Ohkanda J, Yen T, Hamilton AD and Sebti SM: The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. J Biol Chem 276: 16161-16167, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 16161-16167
    • Crespo, N.C.1    Ohkanda, J.2    Yen, T.3    Hamilton, A.D.4    Sebti, S.M.5
  • 23
    • 0028869067 scopus 로고
    • Inhibition of human tumor xenograft growth by treatment with the farnesyltransferase inhibitor B956
    • Nagasu T, Yoshimatsu K, Rowell C, Lewis MD and Garcia AM: Inhibition of human tumor xenograft growth by treatment with the farnesyltransferase inhibitor B956. Cancer Res 55: 5310-5314, 1995.
    • (1995) Cancer Res , vol.55 , pp. 5310-5314
    • Nagasu, T.1    Yoshimatsu, K.2    Rowell, C.3    Lewis, M.D.4    Garcia, A.M.5
  • 24
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesylprotein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A and Rosen N: A peptidomimetic inhibitor of farnesylprotein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res 55: 5302-5309, 1995.
    • (1995) Cancer Res , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3    Kohl, N.E.4    Gibbs, J.B.5    Oliff, A.6    Rosen, N.7
  • 25
    • 0032932257 scopus 로고    scopus 로고
    • Activity of SCH 66336, a tricyclic farnesyltransferase inhibitor, against human tumor colony-forming units
    • DOI 10.1023/A:1008313232381
    • Petit T, Izbicka E, Lawrence RA, Bishop WR, Weitman S and von Hoff DD: Activity of SCH66336, a tricyclic farnesyltransferase inhibitor, against human tumor colony-forming units. Ann Oncol 10: 449-453, 1999. (Pubitemid 29236423)
    • (1999) Annals of Oncology , vol.10 , Issue.4 , pp. 449-453
    • Petit, T.1    Izbicka, E.2    Lawrence, R.A.3    Bishop, W.R.4    Weitman, S.5    Von Hoff, D.D.6
  • 26
    • 0028958919 scopus 로고
    • Resistance of K-rasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells
    • James GL, Goldstein JL and Brown MS: Resistance of K-rasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. J Biol Chem 270: 6221-6226, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 6221-6226
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 27
    • 0030968859 scopus 로고    scopus 로고
    • Direct demonstration of geranylgeranylation and farnesylation of Ki-ras in vivo
    • Rowell CA, Kowalczyk JJ, Lewis MD and Garcia AM: Direct demonstration of geranylgeranylation and farnesylation of Ki-ras in vivo. J Biol Chem 273: 20243-20251, 1997.
    • (1997) J Biol Chem , vol.273 , pp. 20243-20251
    • Rowell, C.A.1    Kowalczyk, J.J.2    Lewis, M.D.3    Garcia, A.M.4
  • 29
    • 0032493641 scopus 로고    scopus 로고
    • 1 block in p53 wild type tumor cells
    • DOI 10.1074/jbc.273.32.20243
    • Sepp-Lorenzino L and Rosen N: A farnesyl-protein transferase inhibitor induces p21Cip1 expression and G1 block in p53 wild type tumor cells. J Biol Chem 273: 20243-20251, 1998. (Pubitemid 28377586)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.32 , pp. 20243-20251
    • Sepp-Lorenzino, L.1    Rosen, N.2
  • 31
    • 0033214457 scopus 로고    scopus 로고
    • Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
    • Sun J, Blaskovich MA and Knowles D: Antitumor efficacy of a novel class of non-Thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, taxol and gemcitabine. Cancer Res 59: 4919-4926, 1999. (Pubitemid 29472897)
    • (1999) Cancer Research , vol.59 , Issue.19 , pp. 4919-4926
    • Sun, J.1    Blaskovich, M.A.2    Knowles, D.3    Qian, Y.4    Ohkanda, J.5    Bailey, R.D.6    Hamilton, A.D.7    Sebti, S.M.8
  • 36
    • 0035240617 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: A novel targeted therapy for cancer
    • Johnston SRD: Farnesyltransferase inhibitors: a novel targeted therapy for cancer. Lancet Oncol 2: 18-26, 2001.
    • (2001) Lancet Oncol , vol.2 , pp. 18-26
    • Johnston, S.R.D.1
  • 37
    • 0033652761 scopus 로고    scopus 로고
    • Farnesyltransferase and geranyltransferase I inhibitors in cancer therapy: Important mechanistic and bench to bedside issues
    • Sebti SM and Hamilton AD: Farnesyltransferase and geranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues. Exp Opin Investig Drugs 9: 2767-2782, 2000.
    • (2000) Exp Opin Investig Drugs , vol.9 , pp. 2767-2782
    • Sebti, S.M.1    Hamilton, A.D.2
  • 39
    • 4243577676 scopus 로고    scopus 로고
    • A clinical, pharmacodynamic and pharmacokinetic phase I study of SCH 66336 (SCH) an oral inhibitor of the enzyme farnesyltransferase given once daily in patients with solid tumors
    • Awada A, Eskens F, Piccart MJ, van der Gaast A, Bleiberg H, Cutler DL, Fumoleau P, Wanders J, Faber MN and Verweij J: A clinical, pharmacodynamic and pharmacokinetic phase I study of SCH 66336 (SCH) an oral inhibitor of the enzyme farnesyltransferase given once daily in patients with solid tumors. Clin Cancer Res 5: S3733, 1999.
    • (1999) Clin Cancer Res , vol.5
    • Awada, A.1    Eskens, F.2    Piccart, M.J.3    Van Der Gaast, A.4    Bleiberg, H.5    Cutler, D.L.6    Fumoleau, P.7    Wanders, J.8    Faber, M.N.9    Verweij, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.