메뉴 건너뛰기




Volumn 10, Issue 4, 1999, Pages 449-453

Activity of SCH 66336, a tricyclic farnesyltransferase inhibitor, against human tumor colony-forming units

Author keywords

Farnesyltransferase inhibitor; Human tumor cloning assay; SCH 66336

Indexed keywords

CISPLATIN; DOXORUBICIN; ETOPOSIDE; LONAFARNIB; PACLITAXEL; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0032932257     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008313232381     Document Type: Article
Times cited : (27)

References (28)
  • 2
    • 0023898932 scopus 로고
    • The ras family and human carcinogenesis
    • Bos JL. The ras family and human carcinogenesis. Mutat Res 1988; 195: 255-71.
    • (1988) Mutat Res , vol.195 , pp. 255-271
    • Bos, J.L.1
  • 3
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL. Ras oncogenes in human cancer: A review. Cancer Res 1989; 49: 4682-9.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 4
    • 0026747866 scopus 로고
    • Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
    • Kalo K, Cox AD, Hisaka MM, Graham SM et al. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci USA 1992; 89: 6403-7.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6403-6407
    • Kalo, K.1    Cox, A.D.2    Hisaka, M.M.3    Graham, S.M.4
  • 5
    • 0024406286 scopus 로고
    • All ras protein are polyisoprenylated but only some are palmitoylated
    • Hancock JF, Magee AI, Childs JE, Marshall CJ. All ras protein are polyisoprenylated but only some are palmitoylated. Cell 1989; 57: 1167-77.
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 6
    • 0021528719 scopus 로고
    • Harvey murine sarcoma virus p21 ras protein: Biological and biochemical significance of the cysteine nearest the carboxy terminus
    • Willumsen BM, Norris K, Papageorge AG et al. Harvey murine sarcoma virus p21 ras protein: Biological and biochemical significance of the cysteine nearest the carboxy terminus. EMBO J 1984; 3:2581-5.
    • (1984) EMBO J , vol.3 , pp. 2581-2585
    • Willumsen, B.M.1    Norris, K.2    Papageorge, A.G.3
  • 7
    • 0025877861 scopus 로고
    • Ras C-terminal processing enzymes - New drug targets?
    • Gibbs JB. Ras C-terminal processing enzymes - new drug targets? Cell 1991: 65: 1-4.
    • (1991) Cell , vol.65 , pp. 1-4
    • Gibbs, J.B.1
  • 8
    • 0028331587 scopus 로고
    • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
    • Gibbs JB, Oliff A, Kohl NE. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 1994; 77: 175-8.
    • (1994) Cell , vol.77 , pp. 175-178
    • Gibbs, J.B.1    Oliff, A.2    Kohl, N.E.3
  • 9
    • 0029586503 scopus 로고
    • Novel tricyclic inhibitors of farnesyl protein transferase
    • Bishop WR, Bond R, Petrin J, Wang L et al. Novel tricyclic inhibitors of farnesyl protein transferase. J Biol Chem 1995; 51: 30611-8.
    • (1995) J Biol Chem , vol.51 , pp. 30611-30618
    • Bishop, W.R.1    Bond, R.2    Petrin, J.3    Wang, L.4
  • 10
    • 6844259851 scopus 로고    scopus 로고
    • Structure-activity of 3-substituted N-(pyridinylacetyl)-4-(8-chloro-5,6-dihydro-IIH-benzo[5,6]cyclo-hepla[1,2-b] pyridin-11-ylidene)piperidine inhibitors of farnesyl-protein transferase: Design and synthesis of in vivo active antitumor compounds
    • Njoroge FG, Vibulbhan B, Rane DF et al. Structure-activity of 3-substituted N-(pyridinylacetyl)-4-(8-chloro-5,6-dihydro-IIH-benzo[5,6]cyclo-hepla[1,2-b] pyridin-11-ylidene)piperidine inhibitors of farnesyl-protein transferase: Design and synthesis of in vivo active antitumor compounds. J Med Chem 1997; 40: 4290-301.
    • (1997) J Med Chem , vol.40 , pp. 4290-4301
    • Njoroge, F.G.1    Vibulbhan, B.2    Rane, D.F.3
  • 11
    • 0031030828 scopus 로고    scopus 로고
    • Antitumor 8-chlorobenzocycloheptapyridines: A new class of selective, nonpeptidic, nonsulfhydryl inhibitors of Ras farnesylation
    • Mallams AK, Njoroge FG, Doll RJ et al. Antitumor 8-chlorobenzocycloheptapyridines: A new class of selective, nonpeptidic, nonsulfhydryl inhibitors of Ras farnesylation. Bioorg Med Chem 1997; 5: 93-9.
    • (1997) Bioorg Med Chem , vol.5 , pp. 93-99
    • Mallams, A.K.1    Njoroge, F.G.2    Doll, R.J.3
  • 12
    • 15644380004 scopus 로고    scopus 로고
    • Inhibitors of farnesyl protein transferase. 4-amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-y1)piperazine and 1-(3-bromo-8-chloro-6.11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-y1) piperazine
    • Mallans AK, Rossman RR, Doll RJ et al. Inhibitors of farnesyl protein transferase. 4-amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-y1)piperazine and 1-(3-bromo-8-chloro-6.11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-y1) piperazine. J Med Chem 1998:41:877-93.
    • (1998) J Med Chem , vol.41 , pp. 877-893
    • Mallans, A.K.1    Rossman, R.R.2    Doll, R.J.3
  • 13
    • 0017785769 scopus 로고
    • Primary bioassay of human myeloma stem cell
    • Hamburger AW, Salmon SE. Primary bioassay of human myeloma stem cell. Science 1977; 197: 471.
    • (1977) Science , vol.197 , pp. 471
    • Hamburger, A.W.1    Salmon, S.E.2
  • 14
    • 0025051987 scopus 로고
    • Selection of cancer chemotherapy for patient by an in vitro assay versus a clinician
    • Von Hoff DD, Sandbach J, Clark G et al. Selection of cancer chemotherapy for patient by an in vitro assay versus a clinician. J Nail Cancer Inst 1990; 82: 110-6.
    • (1990) J Nail Cancer Inst , vol.82 , pp. 110-116
    • Von Hoff, D.D.1    Sandbach, J.2    Clark, G.3
  • 15
    • 0025968045 scopus 로고
    • A Southwest Oncology Group study on the use of a human tumor cloning assay for predicting response in patients with ovarian cancer
    • Von Hoff DD, Kronmal R, Salmon SE et al. A Southwest Oncology Group study on the use of a human tumor cloning assay for predicting response in patients with ovarian cancer. Cancer 1991; 67: 20-7.
    • (1991) Cancer , vol.67 , pp. 20-27
    • Von Hoff, D.D.1    Kronmal, R.2    Salmon, S.E.3
  • 17
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice
    • Liu M, Bryant MS, Chen J et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice. Cancer Res 1998; 58: 4947-56.
    • (1998) Cancer Res , vol.58 , pp. 4947-4956
    • Liu, M.1    Bryant, M.S.2    Chen, J.3
  • 18
    • 0019271327 scopus 로고
    • Tabular summary of pharmacokinetic parameters relevant to in vitro drug assay
    • Salmon SE (ed): New York: Alan R Liss
    • Alberts D, Chen H. Tabular summary of pharmacokinetic parameters relevant to in vitro drug assay. In Salmon SE (ed): Human Tumor Stem Cells. New York: Alan R Liss 1980: 351-9.
    • (1980) Human Tumor Stem Cells , pp. 351-359
    • Alberts, D.1    Chen, H.2
  • 19
    • 0031932939 scopus 로고
    • New approaches to anticancer drug design based on the inhibition of farnesyltransferase
    • Sebti SM, Hamilton AD. New approaches to anticancer drug design based on the inhibition of farnesyltransferase. Drug Disc Today 1988; 3: 26-33.
    • (1988) Drug Disc Today , vol.3 , pp. 26-33
    • Sebti, S.M.1    Hamilton, A.D.2
  • 20
    • 0031983131 scopus 로고    scopus 로고
    • A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
    • Barrington RE, Subler MA, Rands E et al. A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol Cell Biol 1998; 18: 85-92.
    • (1998) Mol Cell Biol , vol.18 , pp. 85-92
    • Barrington, R.E.1    Subler, M.A.2    Rands, E.3
  • 21
    • 0028958919 scopus 로고
    • Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
    • James GL, Goldstein JL, Brown MS. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J Biol Chem 1995; 270: 6221-6.
    • (1995) J Biol Chem , vol.270 , pp. 6221-6226
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 22
    • 0030943198 scopus 로고    scopus 로고
    • Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I
    • Zhang FL, Kirschmeier P, Carr D et al. Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I. J Biol Chem 1997; 272: 10232-9.
    • (1997) J Biol Chem , vol.272 , pp. 10232-10239
    • Zhang, F.L.1    Kirschmeier, P.2    Carr, D.3
  • 23
    • 0030923192 scopus 로고    scopus 로고
    • K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
    • Whyte DB, Kirschmeier P, Hockenberry TN et al. K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem 1997; 272: 14459-64.
    • (1997) J Biol Chem , vol.272 , pp. 14459-14464
    • Whyte, D.B.1    Kirschmeier, P.2    Hockenberry, T.N.3
  • 24
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski MS, Mc Cormick F. Proteins regulating Ras and its relatives. Nature 1993; 366: 643-54.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    Mc Cormick, F.2
  • 25
    • 0027323459 scopus 로고
    • Benzodiazepine peptidomimetics: Potent inhibitors of ras farnesylation in animals cells
    • James GL, Goldstein JL, Brown MS et al. Benzodiazepine peptidomimetics: Potent inhibitors of ras farnesylation in animals cells. Science 1993; 260: 1937-42.
    • (1993) Science , vol.260 , pp. 1937-1942
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 26
    • 0027320616 scopus 로고
    • Peptidomimetic inhibitors of Ras farnesylation and function in whole cells
    • Garcia AM, Rowell C, Ackermann K et al. Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. J Biol Chem 1993; 268: 18415-8.
    • (1993) J Biol Chem , vol.268 , pp. 18415-18418
    • Garcia, A.M.1    Rowell, C.2    Ackermann, K.3
  • 27
    • 0013553224 scopus 로고    scopus 로고
    • SCH 66336, an orally bioavailable tricyclic farnesyl transferase inhibitor blocks anchorage-independent growth of ras-transformed fibroblasts and human tumor cell lines
    • Kirschmeier P, Carr D, Gray K etal. SCH 66336, an orally bioavailable tricyclic farnesyl transferase inhibitor blocks anchorage-independent growth of ras-transformed fibroblasts and human tumor cell lines. Proc Annu Meet Am Assoc Cancer Res 1998; 39: 318.
    • (1998) Proc Annu Meet Am Assoc Cancer Res , vol.39 , pp. 318
    • Kirschmeier, P.1    Carr, D.2    Gray, K.3
  • 28
    • 0344762120 scopus 로고    scopus 로고
    • Pharmacokinetics of a potent orally bioavailable inhibitor of farnesyl protein transferase in the mouse, rat and cynomolgus monkey
    • Bryant MS, Liu M, Wang S et al. Pharmacokinetics of a potent orally bioavailable inhibitor of farnesyl protein transferase in the mouse, rat and cynomolgus monkey. Proc Annu Meet Am Assoc Cancer Res 1998; 39: 319.
    • (1998) Proc Annu Meet Am Assoc Cancer Res , vol.39 , pp. 319
    • Bryant, M.S.1    Liu, M.2    Wang, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.