Induction of an ATPase inhibitor protein by propylthiouracil and protection against paracetamol (acetaminophen) hepatotoxicity in the rat

British Journal of Pharmacology

Volumn 124, Issue 6, 1998, Pages 1041-1047

  Banerjee, Atreyee ^a   Linscheer, Willem G ^a,b   Chiji, Hideyuki ^a,d   Murthy, Uma K ^a,b   Cho, Chaidong ^a,b,e   Nandi, Jyotirmoy ^b   Chan, Samuel H P ^c  

^a SYRACUSE VA MEDICAL CENTER   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

^c SYRACUSE UNIVERSITY   (United States)

^d FUJI WOMEN'S UNIVERSITY   (Japan)

^e Dianon Systems   (United States)

Author keywords

ATPase; ATPase inhibitor protein; Hypothyroidism; Paracetamol (acetaminophen) intoxication; Propylthiouracil; Reduced glutathione

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; AMINOTRANSFERASE; GLUTATHIONE; PARACETAMOL; PROPYLTHIOURACIL; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIVER CELL; LIVER HISTOLOGY; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT;

ACETAMINOPHEN; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; ENZYME INHIBITORS; GLUTATHIONE; LIVER; MALE; PROPYLTHIOURACIL; PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RATS, WISTAR;

EID: 0031823127     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701917     Document Type: Article

References (35)

1. ADAM, H. (1963). Adenosine-5′-triphosphate. Determination with phosphoglycerate kinase. In Methods of Enzymatic Analysis, ed. Bergmeyer, H.U., 539-543. New York: Academic Press.
2. BAGINSKI, E.S., FOA, P.P. & ZAK, B. (1967). Determination of phosphate: Study of labile organic phosphate interference. Clin. Chim. Acta, 15, 155-158.
3. BRUNI, A., PITOTTI, P., DABBENI-SALA, F. & BIGON, E. (1979). F1 ATPase from different submitochondrial particles. Biochim. Biophys. Acta, 545, 404-414.
4. CHAN, S.H.P. & BARBOUR, R.L. (1976). Purification and properties of ATPase inhibitor from rat liver mitochondria. Biochim. Biophys. Acta, 430, 426-433.
5. CHAN, S.H.P. & SCHATZ, G. (1979). Use of Antibodies for Studying the Sidedness of Membrane Components, ed. Fleischer, S & Packer, L. Vol. 56. pp.223-228. New York: Academic Press.
6. +-ATPase in hepatoma 22 a mitochondria. FEBS Lett., 215, 300-304.
7. DAHLIN, D.C., MIWA, G.T., LU, A.Y.H. & NELSON, S.D. (1984). N-Acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. U.S.A., 81, 1327-1331.
8. ELLMAN, G.L. (1959). Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82, 70-77.
9. ENGVALL, E. & PERLMANN, P. (1972). Enzyme-linked immunosorbent assay. ELISA. III. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. J. Immunol., 109, 129-135.
10. GARCIA, M.S., ALBERO, M.I., SANCHEZ-PEDREÑ, C. & TOBA, L. (1995). Kinetic determination of carbimazole, methimazole and PTU in pharmaceuticals. Animal feed and animal livers. Analyst, 120, 129-133.
11. HABIG, W.H., JACOBY, W.B., GUTHENBERG, C., MANNERVIK, B. & VANDER JAGT. (1984). 2-Propylthiouracil does not replace glutathione for the glutathione transferases. J. Biol. Chem., 259, 7409-7410.
12. HARMAN, A.W., KYLE, M.E., SERRONI, A. & FARBER, J.L. (1991). The killing of cultured hepatocytes by N-acetyl-p-benzoquinone Imine (NAPQI) as a model of the cytotoxicity of acetaminophen. Biochem. Pharmacol., 41, 1111-1117.
13. HØRDER, M., GERHARDT, W., HÄRKÖNEN, M., MAGID, E., PITKÄNEN, E., STRÖMME, J.H., THEODORSEN, L. & WALDENSTRÖM, J. (1981). Experiences with the Scandinavian recommended methods for determinations of enzymes in blood. Scand. J. Clin. Lab. Invest., 41, 107-116.
14. HORSTMAN, L.L. & RACKER, E. (1970). Partial resolution of the enzymes catalyzing oxidative phosphorylation. XXII. Interaction between mitochondrial adenosine triphosphatase inhibitor and mitochondrial adenosine triphosphatase. J. Biol. Chem., 245, 1336-1344.
15. LAMARCHE, A.E.P., ABATE, M.I., CHAN, S.H.P. & TRUMPOWER, B.L. (1992). Isolation and characterization of COX12, the nuclear gene for a previously unrecognized subunit of Saccharomyces cerevisiae cytochrome c oxidase. J. Biol. Chem., 267, 22473-22480.
16. LINSCHEER, W.G., RAHEJA, K.L., CHO, C. & SMITH, N.J. (1980). Mechanism of the protective effect of PTU against acetaminophen (Tylenol) toxicity in the rat. Gastroenterology, 78, 100-107.
17. LOWR, O.H., ROSEBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
18. MARTIN, E.L. & MCLEAN, A.E.M. (1995). Adenosine triphosphate (ATP) levels in paracetamol-induced cell injury in the rat in vivo and in vitro. Toxicology, 104, 91-97.
19. MITCHELL, J.R., JOLLOW, D.J., POTTER, W.Z., GILLETTE, J.R. & BRODIE, B.B. (1973). Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther., 187, 211-217.
20. NAZARETH, W.M.A., SETHI, J.K. & MCLEAN, A.E.M. (1991). Effect of paracetamol on mitochondrial membrane function in rat liver slices. Biochem. Pharmacol., 42, 931-936.
21. PEDERSEN, P.L., GREENAWALT, J.W., REYNAFARJE, B., HULLIHEN, J., DECKER, G.L., SOPER, J.W. & BUSTAMENTE, E. (1978). Preparation and characterization of mitochondria and submitochondria particles of rat liver and liver-derived tissues. Methods Cell Biol., 20, 411-481.
22. POTTER, W.Z., DAVIS, D.C., MITCHELL, J.R., JOLLOW, D.J., GILLETTE, J.R. & BRODIE, B.B. (1973). Acetaminophen-induced hepatic cirrhosis. LII. Cytochrome p-450-mediated covalent binding in vivo. J. Pharmacol. Exp. Ther., 187, 203-210.
23. PULLMAN, M.E. & MONROY, G.C. (1963). A naturally occurring inhibitor of mitochondrial adenosine triphosphatase. J. Biol. Chem., 235, 3262-3269.
24. RAHEJA, K.L., LINSCHEER, W.G., CHO, C. & MAHANY, D. (1982). Protective effect of propylthiouracil independent of its hypothyroid effect on acetaminophen toxicity in the rat acetaminophen toxicity in the rat. J. Pharmacol. Exp. Ther., 220, 427-434.
25. RAHEJA, K.L., LINSCHEER, W.G. & CHO, C. (1983). Prevention of acetaminophen hepato-toxicity by propylthiouracil in the glutathione depleted rat. Comp. Biochem. Physiol., 76 C, 9-14.
26. RAHEJA, K.L., LINSCHEER, W.G. & CHIJIIWA, K. (1984). Effect of propyluracil (PTU) pretreatment on hepatic glutathione turnover and synthesis rate in the rat. Gastroenterology, 86, 1216.
27. RAHEJA, K.L., LINSCHEER, W.G., CHIJIIWA, K. & IBA, M. (1985). Inhibitory effect of propylthiouracil-induced hypothyroidism in rat on oxidative drug metabolism. Comp. Biochem. Physiol., 82 C, 17-19.
28. REDEGELD, F.A.M., MOISON, R.M.W., KOSTER, A.S. & NOORDHOEK, J. (1992). Depletion of ATP but not GSH affects viability of rat hepatocytes. Eur. J. Pharmacol., 228, 229-236.
29. ROUSLIN, W. (1988). Factors affecting the loss of mitochondrial function during zero-flow ischemia (autolysis) in slow and fast heart-rate hearts. J. Mol. Cell Cardiol., 20, 999-1007.
30. ROUSLIN, W. & BROGE, C.W. (1989). Factor affecting the reactivation of the mitochondrial adenosine 5′-triphosphatase and the release of ATPase inhibitor protein during and following the reenergization of mitochondria from ischemic cardiac muscle. Arch. Biochem. Biophys., 275, 385-394.
31. SAH, J.F., KUMAR, C. & MOHANTY, P. (1993). pH dependent conformational changes modulate functional activity of the mitochondrial ATPase inhibitor protein. Biochem. Biophys. Res. Commun., 194, 1521-1528.
32. SCHWERZMANN, K. & PEDERSEN, P.L. (1986). Regulation of the mitochondrial ATPsynthase/ATPase complex. Arch. Biochem. Biophys. 250, 1-18.
33. TIRMENSTEIN, M.A. & NELSON, S.D. (1989). Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a non-hepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver. J. Biol. Chem., 264, 9809-9814.
34. YAMADA, T. & KAPLOWITZ, N. (1980). Propylthiouracil: A substrate for glutathione s-transferases that competes with glutathione. J. Biol. Chem., 255, 3508-3513.
35. YAMADA, T., LUDWIG, S., KUHLENKAMP, J. & KAPLOWITZ, N. (1981). Direct protection against acetaminophen hepato-toxicity by PTU. J. Clin. Invest., 67, 688-695.