Cancer proteomics: From biomarker discovery to signal pathway profiling

Cancer Journal

Volumn 7, Issue 1, 2001, Pages 69-78

  Bichsel, V E ^a   Liotta, L A ^a   Petricoin III, E F ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Cancer; Microdissection; Pharmacoproteomics; Proteomics; Signaling

Indexed keywords

PROTEIN; PROTEOME;

CANCER DIAGNOSIS; CHROMOSOME MICRODISSECTION; DEVICE; DISEASE MARKER; DNA FINGERPRINTING; GENE TARGETING; MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; SIGNAL TRANSDUCTION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

BIOLOGICAL MARKERS; CELL SEPARATION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; PEPTIDE MAPPING; PROTEOME; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

EID: 0035090308     PISSN: 15289117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Protein abundancy and mRNA levels of the adipocyte-type fatty acid binding protein correlate in non-invasive and invasive bladder transitional cell carcinomas
2. Expression profiles of active genes in human and mouse livers
3. In vivo gene expression profile analysis of human breast cancer progression
4. A comparison of selected mRNA and protein abundances in human liver
5. Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program
6. Correlation between protein and mRNA abundance in yeast
7. Reproductive state of rat mammary gland stroma modulates human breast cancer cell migration and invasion
8. Fibroblasts are critical determinants in prostatic cancer growth and dissemination
9. Activation of matrix metalloprotemase-2 in head and neck squamous cell carcinoma: Studies of clinical samples and in vitro cell lines co-cultured with fibroblasts
10. Hepatocyte-derived soluble factors regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability
11. Interactions between normal mammary epithelial cells and mammary tumour cells in a model system
12. Collagen substrata for studies on cell bahavior
13. Growth and cellular characteristics of multicell spheroids
14. Long term organ culture of human prostate tissue in a NASA-designed rotating wall bioreactor
15. Mouse prostate reconstitution model system: A series of in vivo and in vitro models for benign and malignant prostatic disease
16. Use of nude mouse xenograft models in prostate cancer research
17. Different hormonal requirements for androgen-independent growth of normal and tumor epithelial cells from rat prostate
18. Characterization of intracellular prostate-specific antigen from laser capture microdissected benign and malignant prostatic epithelium
19. Two-dimensional polyacrylamide gel electrophoresis of human lung cancer: Qualitative aspects of tissue preparation in relation to histopathology
20. Sample preparation of human tumors prior to two-dimensional electrophoresis of proteins
21. Specific sample preparation in colorectal cancer
22. Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties
23. Ablation of polymers and biological tissue by ultraviolet lasers
24. Laser capture micro-dissection: Molecular analysis of tissue
25. Laser capture micro-dissection
26. Mass spectrometry: From genomics to proteomics
27. Characterization of peptides bound to the class 1 MHC molecule HLA-A2. 1 by mass spectrometry
28. Protein identification at the low femtomole level from silver-stained gels using a new fritless electrospray interface for liquid chromatography-microspray and nanospray mass spectrometry
29. Direct analysis and identification of proteins in mixtures by LC/MS/MS and database searching a the low-femtomole level
30. Electrospray and Taylor-Cone theory. Doles beam of macromolecules at last?
31. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry
32. Quantitative analysis of complex protein mixtures using isotope-code affinity tags
33. Keratin expression and its significance in five cultured melanoma cell lines derived form primary, recurrent and metastasized melanomas
34. Identification of keratins 18, 19 and heat-shock protein 90 beta as candidate substrate of proteolysis during ionizing radition -induced apoptosis of estrogen-receptor negative breast tumor cells
35. Differential expression of stathmin during neoplastic conversion of human prostate epithelial cells is reversed by hypomethylating agent 5-azacytidine
36. Effect of glucocorticoid hormone on nuclear matrix in cervical cancer cells in vitro
37. Bladder squamous cell carcinoma biomarkers derived from proteomics
38. An approach to proteomic analysis of human tumors
39. Two-dimensional electrophoretic study of normal colon mucosa and colored cancer
40. Quantitative protein changes in metastatic versus primary epithelial ovarian carcinoma
41. Characterization of gene expression in clinical lung cancer materials by two-dimensional polyacrylamide gel electrophoresis
42. Renal cell carcinoma and normal kidney protein expression
43. Differential expression of Hsp27 in normal oesophagus, Barrett's metaplasia and oesophageal adenocarcinomas
44. Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas
45. A two-dimensional electrophoresis database of human breast epithelial cell proteins
46. A two-dimensional gel database of human colon carcinoma proteins
47. The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis: Preliminary findings
48. Proteomic analysis of laser capture microdissected human prostate cancer and in vitro prostate cell lines
49. '98 Escherichia coli SWISS-2DPAGE database update
50. The dynamic range of protein expression: A challenge for proteomic research
51. Toward a clinical molecular scanner for proteome research: Parallel protein chemical processing before and during western blot
52. A molecular scanner to automate proteomic research and to display proteome images
53. Tissue microarrays for high-throughput molecular profiling of tumor specimens
54. Computerized classification of two-dimensional gel electrophoretograms by correspondence analysis and ascendant hierarchical clustering
55. Lung tumor cells: A multivariate approach to cell classification using two-dimensional protein pattern
56. Classification of human ovarian tumors using multivariate data analysis of polypeptide expression patterns
57. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
58. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
59. Systematic variation in gene expression patterns in human cancer cell lines
60. New desorption strategies for the mass spectrometric analysis of macromolecules
61. Rapid protein display profiling of cancer progression directly from human tissue using a protein biochip
62. Ultrasensitive detection of prostate-specific antigen by a time-resolved immunofluorometric assay and the immulite immunochemiluminescent third-generation assay: Potential applications in prostate and breast cancers
63. Sensitive immunoassay of tissue cell proteins procured by laser capture microdissection
64. Protein microchips use for immunoassay and enzymatic reactions
65. Monoclonal antibody binding affinity determined by microchip-based capillary electrophoresis
66. Developing multianalyte assays
67. Light-directed, spatially addressable parallel chemical synthesis
68. Advanced multiplexed analysis with the FlowMetrix system
69. UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA and protein-ligand interactions
70. Microminiaturized immuno-assays using atomic force microscopy and compositionally patterned antigen arrays
71. Protein microarrays for gene expression and antibody screening
72. High-throughput microarray-based enzyme-linked immunosorbent assay (ELISA)
73. Multianalyte detection using a capillary-based flow immunosensor
74. Array biosensor for simultaneous identification of bacterial, viral, and protein analytes
75. Mass-sensing, multianalyte microarray immunoassay with imaging detection
76. Fabrication of microarray of gel-immobilized compounds on a chip by copolymerization
77. Detection of multiple toxic agents using a planar array immunosensor
78. Mapping signal, transduction pathways by phage display