Forced homo-oligomerization of RARα leads to transformation of primary hematopoietic cells

Cancer Cell

Volumn 9, Issue 2, 2006, Pages 95-108

  Kwok, Colin ^a   Zeisig, Bernd B ^a   Dong, Shuo ^b   So, Chi Wai Eric ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FK 506 BINDING PROTEIN; HYBRID PROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN PLZF; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; GENE CONSTRUCT; GENE REPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR MIMICRY; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE;

EID: 32044463370     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2006.01.005     Document Type: Article

References (49)

1. P. Chambon A decade of molecular biology of retinoic acid receptors FASEB J. 10 1996 940 954
2. J.D. Chen, K. Umesono, and R.M. Evans SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers Proc. Natl. Acad. Sci. USA 93 1996 7567 7571
3. H. Chen, R.J. Lin, R.L. Schiltz, D. Chakravarti, A. Nash, L. Nagy, M.L. Privalsky, Y. Nakatani, and R.M. Evans Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300 Cell 90 1997 569 580
4. S. Dong, and D.J. Tweardy Interactions of STAT5b-RARα, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways Blood 99 2002 2637 2646
5. S. Dong, J. Zhu, A. Reid, P. Strutt, F. Guidez, H.J. Zhong, Z.Y. Wang, J. Licht, S. Waxman, and C. Chomienne Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-α fusion protein Proc. Natl. Acad. Sci. USA 93 1996 3624 3629
6. S. Dong, J. Qiu, D.L. Stenoien, W.R. Brinkley, M.A. Mancini, and D.J. Tweardy Essential role for the dimerization domain of NuMA-RARα in its oncogenic activities and localization to NuMA sites within the nucleus Oncogene 22 2003 858 868
7. C. Du, R.L. Redner, M.P. Cooke, and C. Lavau Overexpression of wild-type retinoic acid receptor α (RARα) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARα-fusion genes Blood 94 1999 793 802
8. M. Eguchi, M. Eguchi-Ishimae, and M. Greaves The small oligomerization domain of Gephyrin converts MLL to an oncogene Blood 103 2004 3876 3882
9. B. Falini, C. Mecucci, E. Tiacci, M. Alcalay, R. Rosati, L. Pasqualucci, R. La Starza, D. Diverio, E. Colombo, and A. Santucci Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype N. Engl. J. Med. 352 2005 254 266
10. F. Felicetti, L. Bottero, N. Felli, G. Mattia, C. Labbaye, E. Alvino, C. Peschle, M.P. Colombo, and A. Care Role of PLZF in melanoma progression Oncogene 23 2004 4567 4576
11. P.F. Ferrucci, F. Grignani, M. Pearson, M. Fagioli, I. Nicoletti, and P.G. Pelicci Cell death induction by the acute promyelocytic leukemia-specific PML/RARα fusion protein Proc. Natl. Acad. Sci. USA 94 1997 10901 10906
12. F. Grignani, U. Testa, D. Rogaia, P.F. Ferrucci, P. Samoggia, A. Pinto, D. Aldinucci, V. Gelmetti, M. Fagioli, and M. Alcalay Effects on differentiation by the promyelocytic leukemia PML/RARα protein depend on the fusion of the PML protein dimerization and RARα DNA binding domains EMBO J. 15 1996 4949 4958
13. F. Grignani, S. De Matteis, C. Nervi, L. Tomassoni, V. Gelmetti, M. Cioce, M. Fanelli, M. Ruthardt, F.F. Ferrara, and I. Zamir Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia Nature 391 1998 815 818
14. F. Grignani, V. Gelmetti, M. Fanelli, D. Rogaia, S. De Matteis, F.F. Ferrara, D. Bonci, C. Nervi, and P.G. Pelicci Formation of PML/RARα high molecular weight nuclear complexes through the PML coiled-coil region is essential for the PML/RARα-mediated retinoic acid response Oncogene 18 1999 6313 6321
15. S. Grisendi, R. Bernardi, M. Rossi, K. Cheng, L. Khandker, K. Manova, and P.P. Pandolfi Role of nucleophosmin in embryonic development and tumorigenesis Nature 437 2005 147 153
16. F. Guidez, S. Ivins, J. Zhu, M. Soderstrom, S. Waxman, and A. Zelent Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia Blood 91 1998 2634 2642
17. L.Z. He, F. Guidez, C. Tribioli, D. Peruzzi, M. Ruthardt, A. Zelent, and P.P. Pandolfi Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL Nat. Genet. 18 1998 126 135
18. L.Z. He, M. Bhaumik, C. Tribioli, E.M. Rego, S. Ivins, A. Zelent, and P.P. Pandolfi Two critical hits for promyelocytic leukemia Mol. Cell 6 2000 1131 1141
19. S.H. Hong, G. David, C.W. Wong, A. Dejean, and M.L. Privalsky SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia Proc. Natl. Acad. Sci. USA 94 1997 9028 9033
20. D. Kamashev, D. Vitoux, and H. de Thé PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation J. Exp. Med. 199 2004 1163 1174
21. R. Kurokawa, M. Soderstrom, A. Horlein, S. Halachmi, M. Brown, M.G. Rosenfeld, and C.K. Glass Polarity-specific activities of retinoic acid receptors determined by a co-repressor Nature 377 1995 451 454
22. C. Lavau, S.J. Szilvassy, R. Slany, and M.L. Cleary Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL EMBO J. 16 1997 4226 4237
23. R.J. Lin, and R.M. Evans Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers Mol. Cell 5 2000 821 830
24. R.J. Lin, L. Nagy, S. Inoue, W. Shao, W.H. Miller Jr., and R.M. Evans Role of the histone deacetylase complex in acute promyelocytic leukaemia Nature 391 1998 811 814
25. N.J. Marianayagam, M. Sunde, and J.M. Matthews The power of two: protein dimerization in biology Trends Biochem. Sci. 29 2004 618 625
26. M.E. Martin, T.A. Milne, S. Bloyer, K. Galoian, W. Shen, D. Gibbs, H.W. Brock, R. Slany, and J.L. Hess Dimerization of MLL fusion proteins immortalizes hematopoietic cells Cancer Cell 4 2003 197 207
27. A.B. Maurer, C. Wichmann, A. Gross, H. Kunkel, T. Heinzel, M. Ruthardt, B. Groner, and M. Grez The Stat5-RARα fusion protein represses transcription and differentiation through interaction with a corepressor complex Blood 99 2002 2647 2652
28. M.J. McConnell, N. Chevallier, W. Berkofsky-Fessler, J.M. Giltnane, R.B. Malani, L.M. Staudt, and J.D. Licht Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression Mol. Cell. Biol. 23 2003 9375 9388
29. A. Melnick, K.F. Ahmad, S. Arai, A. Polinger, H. Ball, K.L. Borden, G.W. Carlile, G.G. Prive, and J.D. Licht In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions Mol. Cell. Biol. 20 2000 6550 6567
30. A. Melnick, G. Carlile, K.F. Ahmad, C.L. Kiang, C. Corcoran, V. Bardwell, G.G. Prive, and J.D. Licht Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors Mol. Cell. Biol. 22 2002 1804 1818
31. S. Minucci, M. Maccarana, M. Cioce, P. De Luca, V. Gelmetti, S. Segalla, L. Di Croce, S. Giavara, C. Matteucci, and A. Gobbi Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation Mol. Cell 5 2000 811 820
32. S. Minucci, S. Monestiroli, S. Giavara, S. Ronzoni, F. Marchesi, A. Insinga, D. Diverio, P. Gasparini, M. Capillo, and E. Colombo PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors Blood 100 2002 2989 2995
33. H. Nakajima, P.K. Brindle, M. Handa, and J.N. Ihle Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription EMBO J. 20 2001 6836 6844
34. S.A. Onate, S.Y. Tsai, M.J. Tsai, and B.W. O'Malley Sequence and characterization of a coactivator for the steroid hormone receptor superfamily Science 270 1995 1354 1357
35. P.P. Pandolfi Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia Hum. Mol. Genet. 10 2001 769 775
36. A. Perez, P. Kastner, S. Sethi, Y. Lutz, C. Reibel, and P. Chambon PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR EMBO J. 12 1993 3171 3182
37. J.L. Pollock, P. Westervelt, A.K. Kurichety, P.G. Pelicci, J.L. Grisolano, and T.J. Ley A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα-driven acute promyelocytic leukemia Proc. Natl. Acad. Sci. USA 96 1999 15103 15108
38. E. Puccetti, X. Zheng, D. Brambilla, A. Seshire, T. Beissert, S. Boehrer, H. Nurnberger, D. Hoelzer, O.G. Ottmann, C. Nervi, and M. Ruthardt The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARα Cancer Res. 65 2005 6080 6088
39. R.L. Redner, J.D. Chen, E.A. Rush, H. Li, and S.L. Pollock The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties Blood 95 2000 2683 2690
40. M. Ruthardt, U. Testa, C. Nervi, P.F. Ferrucci, F. Grignani, E. Puccetti, C. Peschle, and P.G. Pelicci Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling Mol. Cell. Biol. 17 1997 4859 4869
41. R.K. Slany, C. Lavau, and M.L. Cleary The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX Mol. Cell. Biol. 18 1998 122 129
42. C.W. So, and M.L. Cleary Dimerization: a versatile switch for oncogenesis Blood 104 2004 919 922
43. C.W. So, S. Dong, C.K. So, G.X. Cheng, Q.H. Huang, S.J. Chen, and L.C. Chan The impact of differential binding of wild-type RARα, PML-, PLZF- and NPM-RARα fusion proteins towards transcriptional co-activator, RIP-140, on retinoic acid responses in acute promyelocytic leukemia Leukemia 14 2000 77 83
44. C.W. So, H. Karsunky, E. Passegue, A. Cozzio, I.L. Weissman, and M.L. Cleary MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice Cancer Cell 3 2003 161 171
45. C.W. So, M. Lin, P.M. Ayton, E.H. Chen, and M.L. Cleary Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias Cancer Cell 4 2003 99 110
46. T. Sternsdorf, V.T. Phan, M.L. Maunakea, C.B. Ocampo, J. Sohal, A. Silletto, F. Galimi, M.M. Le Beau, R.M. Evans, and S.C. Kogan Forced retinoic acid receptor α homodimers prime mice for APL-like leukemia Cancer Cell 9 2006 81 94 this issue
47. A. Takeshita, G.R. Cardona, N. Koibuchi, C.S. Suen, and W.W. Chin TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1 J. Biol. Chem. 272 1997 27629 27634
48. A. Zelent, F. Guidez, A. Melnick, S. Waxman, and J.D. Licht Translocations of the RARα gene in acute promyelocytic leukemia Oncogene 20 2001 7186 7203
49. J. Zhu, J. Zhou, L. Peres, F. Riaucoux, N. Honore, S. Kogan, and H. de Thé A sumoylation site in PML/RARA is essential for leukemic transformation Cancer Cell 7 2005 143 153