In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions

Molecular and Cellular Biology

Volumn 20, Issue 17, 2000, Pages 6550-6567

  Melnick, A ^a   Ahmad, F K ^a   Arai, S ^a   Polinger, A ^a   Ball, H ^a   Borden, K L ^a   Carlile, G W ^a   Prive, G G ^a   Licht, J D ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ARTICLE; DIMERIZATION; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; TRANSCRIPTION REGULATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ARGININE; CELL LINE; CIRCULAR DICHROISM; DIMERIZATION; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; ESCHERICHIA COLI; FLUORESCENT ANTIBODY TECHNIQUE; GENES, REPORTER; GLUTAMINE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRYPSIN; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0033838360     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.17.6550-6567.2000     Document Type: Article

References (50)

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12. Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein
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23. The ZiN/POZ domain of ZF5 is required for both transcriptional activation and repression
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