Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors

Molecular and Cellular Biology

Volumn 22, Issue 6, 2002, Pages 1804-1818

  Melnick, Ari ^a   Carlile, Graeme ^a   Ahmad, K Farid ^a   Kiang, Chih Li ^a   Corcoran, Connie ^a   Bardwell, Vivian ^a   Prive, Gilbert G ^a   Licht, Jonathan D ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 6; ZINC FINGER PROTEIN;

ARTICLE; HUMAN; HUMAN CELL; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROMOTER REGION; PROMYELOCYTIC LEUKEMIA; PROTEIN DNA INTERACTION; REPRESSOR GENE; TRANSCRIPTION REGULATION;

AMINO ACID MOTIFS; CELL LINE; DIMERIZATION; DNA-BINDING PROTEINS; HISTONE DEACETYLASES; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0036183641     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.6.1804-1818.2002     Document Type: Article

References (54)

1. Crystal structure of the BTB domain from PLZF
2. The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase
3. Plzf regulates limb and axial skeletal patterning
4. BCL-6 protein is expressed in germinal-center B cells
5. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor
6. Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
7. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein
8. Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: The case of HIC-1 and gammaFBP-B
9. Control of inflammation, cytokine expression, and germinal center formation by BCL-6
10. The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo
11. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein
12. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression
13. Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein
14. Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: Association with diffuse large-cell subtype
15. The coregulator exchange in transcriptional functions of nuclear receptors
16. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia
17. Evolutionary divergence in the broad complex, tramtrack and bric a brac/poxviruses and zinc finger domain from the candidate tumor suppressor gene hypermethylated in cancer
18. Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia
19. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL
20. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF
21. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia
22. The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis
23. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT
24. BCoR, a novel corepressor involved in BCL-6 repression
25. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology
26. A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain
27. Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies
28. Tramtrack69 is positively and autonomously required for Drosophila photoreceptor development
29. Initial sequencing and analysis of the human genome
30. Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein
31. Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein
32. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)
33. Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia
34. Role of the histone deacetylase complex in acute promyelocytic leukaemia
35. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma
36. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions
37. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein
38. Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer
39. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor
40. An alternative pathway for gene regulation by Myc
41. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor
42. Functional studies of the BTB domain in the Drosophila GAGA and Mod-(mdg4) proteins
43. Avian erythroleukemia: A model for corepressor function in cancer
44. Transcriptional repression by the proto-oncogene BCL-6
45. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
46. The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis
47. Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6
48. Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression
49. The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye
50. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6
51. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
52. Leukemia translocation protein PLZF inhibits cell growth and expressionof cyclin A
53. Long range interaction of cis-DNA elements mediated by architectural transcription factor Bachl
54. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila