Overexpression of wild-type retinoic acid receptor α (RARα) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia rarα-fusion genes

Blood

Volumn 94, Issue 2, 1999, Pages 793-802

  Du, Changchun ^b   Redner, Robert L ^b   Cooke, Michael P ^b   Lavau, Catherine ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CARCINOGENESIS; CELL IMMORTALIZATION; CELL TRANSFORMATION; CHROMOSOME TRANSLOCATION; FUSION GENE; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

EID: 0033566289     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.2.793     Document Type: Article

References (50)

1. De Thé H, Marchio A, Tiollais P, Dejean A: Differential expression and ligand regulation of the retinoic acid receptor α and β genes. EMBO J 8:429, 1989
2. Ruberte E, Dolle P, Chambon P, Morriss-Kay G: Retinoic acid receptors and cellular retinoid binding proteins II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 111:45, 1991
3. Chiba H, Clifford J, Metzger D, Chambon P: Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoic target genes in F9 embryonal carcinoma cells. Mol Cell Biol 17:3013, 1997
4. Grunstein M: Histone acetylation in chromatin structure and transcription. Nature 389:349, 1997
5. Collins S, Robertson K, Mueller L: Retinoic acid-induced differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-α). Mol Cell Biol 10:2154, 1990
6. Tsai S, Bartelemez S, Sitnicka E, Collins S: Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development. Genes Dev 8:2831, 1994
7. Koken HM, Linares-Cruz G, Quignon F, Viron A, Chelbi-Alix MK, Sobczak-Thépot J, Juhlin L, Degos L, Calvo F, De Thé H: The PML growth-suppressor has an altered expression in human oncogenesis. Oncogene 10:1315, 1995
8. Mu Z, Chin K, Liu J, Lozano G, Chang K: PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol 14:6858, 1994
9. De Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A: The PML-RAR-alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66:675, 1991
10. Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P: Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): Structural similarities with a new family of oncoproteins, EMBO J 11:629, 1992
11. Lin RJ, Nagy L, Inoue S, Shao W Jr, Miller WH, Evans RM: Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391:811, 1998
12. Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A: Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J 12:1161, 1993
13. Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ: The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood 87:882, 1996
14. Wells R, Catzavelos C, Kamel-Reid S: Fusion of retinoic acid receptor α to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Nat Genet 17:109, 1997
15. Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A: Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML-and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. Blood 91:2634, 1998
16. He L-Z, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP: Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL. Nat Genet 18:126, 1998
17. Hong S-H, David G, Wong C-W, Dejean A, Privalsky ML: SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:9028, 1997
18. Shaknovich R, Yeyati PL, Irvins S, Melnick A, Lempert C, Waxman S, Zelent A, Licht J: The promyelocytic leukemia zinc ringer protein affects myeloid cell growth, differentiation, and apoptosis. Mol Cell Biol 18:5533, 1998
19. Ruthardt M, Orleth A, Tomassoni L, Puccetti E, Riganelli D, Alcalay M, Mannucci R, Nicoletti I, Grignani F, Fagioli M, Pelicci PG: The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies. Oncogene 16:1945, 1998
20. Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, Atwater S, Bishop JM: A PMLRARα transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:2551, 1997
21. Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ: Altered myeloid development and acute leukemia in transgenic mice expressing PML-RARα under control of cathepsin G regulatory sequences. Blood 89:376, 1997
22. He L-Z, Tribioli C, Rivi R, Peruzzi D, Pelicci PG, Cattoretti VSG, Pandolfi PP: Acute leukemia with promyelocytic features in PML/RARα transgenic mice. Proc Natl Acad Sci USA 94:5302, 1997
23. Grignani F, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Grignani F, Peschle C, Nicoletti I, Pelicci PG: The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:423, 1993
24. Ruthardt M, Testa U, Nervi C, Ferrucci PF, Grignani F, Puccetti E, Grignani F, Peschle C, Pelicci PG: Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor α (RARα) and PLZF-RARα fusion proteins on retinoic acid signalling. Mol Cell Biol 17:4859, 1997
25. Grignani F, Testa U, Rogaia D, Ferrucci PF, Samoggia P, Pinto A, Aldinucci D, Gelmetti V, Fagioli M, Alcalay M, Seeler J, Grignani F, Nicoletti I, Peschle C, Pelicci PG: Effects on differentiation by the promyelocytic leukemia PML/RARα protein depend on the fusion of the PML protein dimerization and RARα DNA binding domain. EMBO J 15:4949, 1996
26. Grignani F, Matteis SD, Nervi C, Tomassoni L, Gelmetti V, Cioces M, Farnelli M, Ruthardt M, Ferrara F, Zamir I, Seiser C, Grignani F, Lazar MA, Minucci S, Pelicci PG: Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukemia. Nature 391:815, 1998
27. Hawley RG, Lieu FHL, Fong AZC, Hawley TS: Versatile retroviral vectors for potential use in gene therapy. Gene Ther 1:136, 1994
28. Brand N, Petkovich M, Krust A, Chambon P, De Thé H, Marchio A, Tiollais P, Dejean A: Identification of a second human retinoic acid receptor. Nature 332:850, 1988
29. Lavau C, Szilvassy S, Slany R, Cleary ML: Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally-transduced HRX-ENL. EMBO J 16:4226, 1997
30. Pear W, Nolan G, Scott M, Baltimore D: Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 90:8392, 1993
31. Slany RK, Lavau C, Cleary ML: The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. Mol Cell Biol 18:122, 1998
32. Ferrucci PF, Grignani F, Pearson M, Fagioli M, Nicoletti I, Pelicci PG: Cell death induction by the acute promyelocytic leukemia-specific PML/RARα fusion protein. Proc Natl Acad Sci USA 94:10901, 1997
33. Altabef M, Garcia M, Lavau C, Bae S-C, Dejean A, Samarut J: A retrovirus carrying the promyelocytic-retinoic acid receptor PML-RARα fusion gene transforms haematopoietic progenitors in vitro and induces acute leukemias. EMBO J 15:2707, 1996
34. Lavau C, Heard JM, Danos O, Dejean A: Retroviral vectors for the transduction of the PML-RARα fusion product of acute promyelocytic leukemia. Exp Hematol 24:544, 1996
35. Damm K, Heyman RA, Umesono K, Evans RM: Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants. Proc Natl Acad Sci USA 90:2989, 1993
36. Chen WY, Bailey EC, McCune SL, Dong J-Y, Townes T: Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc Natl Acad Sci USA 94:5798, 1997
37. Onodera M, Kunisada T, Nishikawa S, Sakiyama Y, Matsumoto S, Nishikawa S-I: Overexpression of retinoic acid receptor α suppresses myeloid cell differentiation at the promyelocyte stage. Oncogene 11:1291, 1995
38. Bauer A, Mikulits W, Lagger G, Stengl G, Brosch G, Beug H: The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors. EMBO J 17:4291, 1998
39. Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C, Grosveld F, Pandolfi PP: Role of PML in cell growth and the retinoic acid pathway. Science 279:1547, 1998
40. Perez A, Kastner P, Sethi S, Lutz Y, Reibel C, Chambon P: PML-RAR homodimers: Distinct DNA binding properties and heteromeric interactions with RXR. EMBO J 12:3171, 1993
41. Wong C-W, Privalsky ML: Transcriptional silencing is defined by isoform-and heterodimer-specific interactions between nuclear hormone receptors and corepressors. Mol Cell Biol 18:5724, 1998
42. Baniahmad A, Thormeyer D, Renkawitz R: τ4/τC/AF-2 of the thyroid hormone receptor relieves silencing of the retinoic acid receptor silencer core independent of both τ4 activation function and full dissociation of corepressors. Mol Cell Biol 17:4259, 1997
43. Jacobsen SE, Fahlman C, Blomhoff HK, Okkenhaug C, Rusten LS, Smeland EB: All-trans and 9-cis retinoic acid: Potent direct inhibitors of primitive murine hematopoietic progenitors in vitro. J Exp Med 179:1665, 1994
44. Purton LE, Bernstein ID, Collins SJ: All-trans retinoic acid has different effects on hematopoietic precursors depending on their maturational state. Blood 92:365a, 1998 (abstr, suppl 1)
45. Jansen JH, Ridder MCd, Geertsma WMC, Erpelinck CAJ, Smit B, Slater R, Reijden BAv, Greef GEd, Sonneveld P, Lowenberg B: Complete remission of t(11;17) positive acute promyelocytic leukemia by all-trans retinoic acid and G-CSF. Blood 92:402a, 1998 (abstr, suppl 1)
46. Müller S, Matunis MJ, Dejean A: Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus. EMBO J 17:61, 1998
47. Raelson JV, Nervi C, Rosenauer A, Benedetti L, Monczak Y, Pearson M, Pelicci PG Jr, Miller WH: The PML/RARα oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells. Blood 88:2826, 1996
48. Zhu J, Koken MHM, Quignon F, Chelbi-Alix MK, Degos L, Yi Wang Z, Chen Z, De Thé H: Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:3978, 1997
49. Yoshida H, Kitnamura K, Tanaka K, Omura S, Miyszaki T, Hachiya T, Ohno R, Naoe T: Accelerated degradation of PML-retinoic acid receptor α (PML-RARα) oncoprotein by all-trans retinoic acid in acute promyelocytic leukemia: Possible role of the proteasome pathway. Cancer Res 56:2945, 1996
50. Koken MHM, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JHS, Zhu J, Dong S, Chen S-J, Tans CC, Licht J, Waxman S, De Thé H, Zelent A: Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proc Natl Acad Sci USA 94:10255, 1997