T-cell response to woodchuck hepatitis virus (WHV) antigens during acute self-limited WHV infection and convalescence and after viral challenge

Journal of Virology

Volumn 72, Issue 7, 1998, Pages 6083-6091

  Menne, Stephan ^a,c   Maschke, Jan ^a,c   Lu, Mengji ^a   Grosse Wilde, Hans ^a   Roggendorf, Michael ^a,b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c Department of Population Medicine and Diagnostic Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; HEPATITIS; HEPATITIS VIRUS; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROVOCATION TEST; REINFECTION; SEROCONVERSION; WOODCHUCK;

EID: 0031747582     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.7.6083-6091.1998     Document Type: Article

References (43)

1. Akbar, A. N., M. Salmon, J. Savill, and G. Janossy. 1993. A possible role for bcl-2 in regulating T-cell memory: a "balancing act" between cell death and survival. Immunol. Today 14:526-532.
2. Asada, M., and J. T. Galambos. 1963. Sorbitol dehydrogenase and hepatocellular injury: an experimental and clinical study. Gastroenterology 44:578-584.
3. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T-cells. Nature (London) 369:407-410.
4. Bertoletti, A., C. Ferrari, F. Fiaccadori, A. Penna, R. Margolskee, H. J. Schlicht, P. Fowler, S. Guilhot, and F. V. Chisari. 1991. HLA class-I human cytotoxic T-cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen. Proc. Natl. Acad. Sci. USA 88:10445-10449.
5. Buendia, M. A. 1994. Hepatitis B viruses and liver cancer: the woodchuck model. Symp. Soc. Gen. Microbiol. 51:183-187.
6. Chisari, F. V., and C. Ferrari. 1997. Viral hepatitis, p. 745-778. In N. Nathanson et al. (ed.). Viral pathogenesis. Lippincott-Raven Publishers, Philadelphia, Pa.
7. Cote, P. J., and J. L. Gerin. 1995. In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation and interleukin-2 production: implications for modeling immunity and therapy in hepatitis B virus infection. Hepatology 22:687-699.
8. Cote, P. J., and J. L. Gerin. 1996. The woodchuck as a model of hepadna-virus infection, pathogenesis and therapy. FORUM Trends Exp. Clin. Med. 6:131-159.
9. + T cells in vitro. J. Virol. 70:7540-7548.
10. Feitelson, M. A., and L.-X. Duan. 1997. Hepatitis B virus x antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma. Am. J. Pathol. 150:1141-1157.
11. Ferrari, C., A. Bertoletti, A. Penna, A. Cavalli, A. Valli, G. Missale, M. Pilli, P. Fowler, T. Giuberti, F. V. Chisari, and F. Fiaccadori. 1991. Identification of immunodominant T-cell epitopes of the hepatitis B virus nucleocapsid antigen. J. Clin. Invest. 88:214-222.
12. Ferrari, C., A. Penna, A. Bertoletti, A. Valli, A. Degli Antoni, T. Giuberti, A. Cavalli, M. A. Petit, and F. Fiaccadori. 1990. Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J. Immunol. 145:3442-3449.
13. Franco, A., C. Ferrari, A. Sette, and F. V. Chisari. 1995. Viral mutations, TCR antagonism and escape from the immune response. Curr. Opin. Immunol. 7:524-531.
14. Gerin, J. L., P. J. Cote, B. E. Korba, R. H. Miller, R. H. Purcell, and B. C. Tennant. 1991. Hepatitis B virus and liver cancer: the woodchuck as an experimental model of hepadnavirus induced liver cancer, p. 556-559. In F. B. Hollinger, S. M. Lemon, and H. Margolis (ed.), Viral hepatitis and liver disease. The Williams & Wilkins Co., Baltimore, Md.
15. Gerin, J. L., R. M. Faust, and P. V. Holland. 1975. Biophysical characterization of the adr subtype of hepatitis B antigen and preparation of anti-r sera in rabbits. J. Immunol. 115:100-105.
16. Hornbuckle, W. E., E. S. Graham, L. Roth, B. H. Baldwin, C. Wickenden, and B. C. Tennant. 1985. Laboratory assessment of hepatic injury in the woodchuck (Marmota monax). Lab. Anim. Sci. 35:376-381.
17. + T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J. Virol. 69:3358-3368.
18. Jung, M.-C., U. Spengler, W. Schraut, R. Hoffmann, R. Zachoval, J. Eisenburg, D. Eichenlaub, G. Riethmüller, G. Paumgartner, H. W. L. Ziegler-Heitbrock, H. Will, and G. R. Pape. 1991. Hepatitis B virus antigen specific T-cell activation in patients with acute and chronic hepatitis B. J. Hepatol. 13:310-317.
19. Kajino, K., A. R. Jilbert, J. Saputelli, C. E. Aldrich, J. Cullen, and W. S. Mason. 1994. Woodchuck hepatitis virus infections: very rapid recovery after a prolonged viremia and infection of virtually every hepatocyte. J. Virol. 68:5792-5803.
20. 3H]adenine uptake in the woodchuck model. Clin. Immunol. Immunopathol. 78:223-227.
21. Löhr, H. F., W. Weber, J. Scnlaak, B. Goergen, K.-H. Meyer zum Büschenfelde, and G. Gerken. 1995. Proliferative response of CD4+ T-cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants. Hepatology 22:61-68.
22. Maschke, J., S. Menne, E. Kreuzfelder, M. Roggendorf, and H. Grosse-Wilde. 1996. First evidence of low thymidine kinase activity in the woodchuck. Immunobiology 196:128.
23. Menne, S., J. Maschke, T. K. Tolle, M. Lu, and M. Roggendorf. 1997. Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope. J. Virol. 71:65-74.
24. Menne, S., J. Maschke, R. Klaes, H. Grosse-Wilde, and M. Roggendorf. 1997. Cellular immune response of woodchucks to woodchuck hepatitis virus surface protein during acute WHV infection, p. 453-457. In M. Rizzetto, R. H. Purcell, J. L. Gerin, and G. Verme (ed.), Viral hepatitis and liver disease. Edizioni Minerva Medica, Turin, Italy.
25. 3H]adenine incorporation. Arch. Virol. 142:511-521.
26. Milich, D. R., J. E. Jones, J. L. Hughes, and T. Maruyama. 1993. Role of T-cell tolerance in the persistence of hepatitis B virus infection. J. Immunother. 14:223-226.
27. Milich, D. R., J. E. Jones, J. L. Hughes, J. Price, A. K. Raney, and A. McLachlan. 1990. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc. Natl. Acad. Sci. USA 487: 6599-6603.
28. Milich, D. R., A. McLachlan, G. B. Thornton, and J. L. Hughes. 1987. Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T-cell site. Nature (London) 329:547-549.
29. Nayersina, R., P. Fowler, S. Guilhot, G. Missale, A. Cerny, H.-J. Schlicht, A. Vitiello, R. Chesnut, J. L. Person, A. G. Redeker, and F. V. Chisari. 1993. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J. Immunol. 150:4659-4671.
30. Penna, A., M. Artini, A. Cavalli, M. Levrero, A. Bertoletti, M. Pilli, F. V. Chisari, B. Rehermann, G. Del Prete, F. Fiaccadori, and C. Ferrari. 1996. Long-lasting memory T cell responses following self-limited acute hepatitis B. J. Clin. Invest. 98:1185-1194.
31. Ponzetto, A., P. J. Cote, E. C. Ford, R. H. Purcell, and J. L. Gerin. 1984. Core antigen and antibody in woodchucks after infection with woodchuck hepatitis virus. J. Virol. 52:70-76.
32. Popper, H., L. Roth, R. H. Purcell, B. C. Tennant, and J. L. Gerin. 1987. Hepatocarcinogenicity of the woodchuck hepatitis virus. Proc. Natl. Acad. Sci. USA 84:866-870.
33. Popper, H., J. W.-K. Shih, J. L. Gerin, D. C. Wong, B. H. Hoyer, W. T. London, D. L. Sly, and R. H. Purcell. 1981. Woodchuck hepatitis and hepatocellular carcinoma: correlation of histologic with virologie observations. J. Hepatol. 1:19-28.
34. Rehermann, B., C. Ferrari, C. Pasquinelli, and F. V. Chisari. 1996. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat. Med. 2:1104-1108.
35. Roggendorf, M., and T. K. Tolle. 1995. The woodchuck: an animal model for hepatitis B virus infection in man. Intervirology 38:100-112.
36. Roos, S., K. Fuchs, and M. Roggendorf. 1989. Protection of woodchucks from infection with woodchuck hepatitis virus (WHV) by immunization with recombinant core protein. J. Gen. Virol. 70:2087-2095.
37. Schödel, F., G. Neckermann, D. Peterson, K. Fuchs, S. Fuller, H. Will, and M. Roggendorf. 1993. Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection. Vaccine 11:624-628.
38. Sprent, J. 1994. T and B cell memory. Cell 76:315-322.
39. Tennant, B. C., and J. L. Gerin. 1994. The woodchuck model of hepatitis B virus infection, p. 1455-1466. In I. M. Arias et al. (ed.), The liver: biology and pathobiology. Raven Press, New York, N.Y.
40. Tyler, G. V. 1984. Natural and experimental infections of woodchuck hepa-titis virus. Ph.D. thesis. University of Pennsylvania.
41. Tyler, G. V., R. L. Snyder, and J. Summers. 1986. Experimental infection of the woodchuck (Marmota monax monax) with woodchuck hepatitis virus. Lab. Invest. 55:51-55.
42. Weiss, S., and B. Bogen. 1991. MHC class II-restricted presentation of intracellular antigen. Cell 64:767-776.
43. Wiesner, I. S., H. M. Rawnsley, F. P. Brooks, and J. R. Senior. 1965. Sorbitol dehydrogenase in the diagnosis of liver disease. Am. J. Dig. Dis. 10:147-151.