Crystal structure and substrate specificity of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

Protein Science

Volumn 14, Issue 8, 2005, Pages 2087-2094

  Qiu, Xiayang ^a,b   Choudhry, Anthony E ^a   Janson, Cheryl A ^a,c   Grooms, Michael ^a   Daines, Robert A ^a   Lonsdale, John T ^a   Khandekar, Sanjay S ^a  

^a GLAXOSMITHKLINE   (United States)

^b PFIZER INC   (United States)

^c Shamrock Structures   (United States)

Author keywords

FabH; Kinetics; Staphylococcus aureus; Substrate specificity; X ray crystallography

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ENZYME INHIBITOR; FATTY ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; ESCHERICHIA COLI; GRAM POSITIVE BACTERIUM; NONHUMAN; PARAMETER; POLYMERIZATION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STATISTICAL SIGNIFICANCE; X RAY CRYSTALLOGRAPHY;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; STAPHYLOCOCCUS AUREUS; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 23644436692     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.051501605     Document Type: Article

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