메뉴 건너뛰기




Volumn 6, Issue 2, 2005, Pages 151-157

Conserved non-genic sequences - An unexpected feature of mammalian genomes

Author keywords

[No Author keywords available]

Indexed keywords

CONSERVED NONGENIC SEQUENCE; EVOLUTION; GENE MUTATION; GENE SEQUENCE; GENETIC DISORDER; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOME; MAMMAL; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; REVIEW;

EID: 13144295005     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrg1527     Document Type: Review
Times cited : (219)

References (55)
  • 1
    • 0024040248 scopus 로고
    • Evolution of the autosomal chorion locus in Drosophila. I. General organization of the locus and sequence comparisons of genes s15 and s19 in evolutionary distant species
    • Martinez-Cruzado, J. C., Swimmer, C., Fenerjian, M. G. & Kafatos, F. C. Evolution of the autosomal chorion locus in Drosophila. I. General organization of the locus and sequence comparisons of genes s15 and s19 in evolutionary distant species. Genetics 119, 663-677 (1988).
    • (1988) Genetics , vol.119 , pp. 663-677
    • Martinez-Cruzado, J.C.1    Swimmer, C.2    Fenerjian, M.G.3    Kafatos, F.C.4
  • 2
    • 0032128198 scopus 로고    scopus 로고
    • Proneural gene self-stimulation in neural precursors: An essential mechanism for sense organ development that is regulated by Notch signaling
    • Culi, J. & Modolell, J. Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. Genes Dev. 12, 2036-2047 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2036-2047
    • Culi, J.1    Modolell, J.2
  • 3
    • 0026524350 scopus 로고
    • Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4
    • Renucci, A. et al. Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4. EMBO J. 11, 1459-1468 (1992).
    • (1992) EMBO J. , vol.11 , pp. 1459-1468
    • Renucci, A.1
  • 4
    • 0027280998 scopus 로고
    • Strong conservation of non-coding sequences during vertebrates evolution: Potential involvement in post-transcriptional regulation of gene expression
    • Duret, L., Dorkeld, F. & Gautier, C. Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expression. Nucleic Acids Res. 21, 2315-2322 (1993).
    • (1993) Nucleic Acids Res. , vol.21 , pp. 2315-2322
    • Duret, L.1    Dorkeld, F.2    Gautier, C.3
  • 5
    • 0034284481 scopus 로고    scopus 로고
    • Conserved noncoding sequences are reliable guides to regulatory elements
    • Hardison, R. C. Conserved noncoding sequences are reliable guides to regulatory elements. Trends Genet. 16, 369-372 (2000).
    • (2000) Trends Genet. , vol.16 , pp. 369-372
    • Hardison, R.C.1
  • 6
    • 0030722935 scopus 로고    scopus 로고
    • Long human-mouse sequence alignments reveal novel regulatory elements: A reason to sequence the mouse genome
    • Hardison, R. C., Oeltjen, J. & Miller, W. Long human-mouse sequence alignments reveal novel regulatory elements: a reason to sequence the mouse genome. Genome Res. 7, 959-966 (1997).
    • (1997) Genome Res. , vol.7 , pp. 959-966
    • Hardison, R.C.1    Oeltjen, J.2    Miller, W.3
  • 7
    • 18744395183 scopus 로고    scopus 로고
    • Numerous potentially functional but non-genic conserved sequences on human chromosome 21
    • Dermitzakis, E. T. et al. Numerous potentially functional but non-genic conserved sequences on human chromosome 21. Nature 420, 578-582 (2002).
    • (2002) Nature , vol.420 , pp. 578-582
    • Dermitzakis, E.T.1
  • 8
    • 1542563409 scopus 로고    scopus 로고
    • Initial sequencing and comparative analysis of the mouse genome
    • Waterston, R. H. et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520-562 (2002).
    • (2002) Nature , vol.420 , pp. 520-562
    • Waterston, R.H.1
  • 9
    • 0034762015 scopus 로고    scopus 로고
    • Evolutionary conserved sequences on human chromosome 21
    • Frazer, K. A. et al. Evolutionary conserved sequences on human chromosome 21. Genome Res. 11, 1651-1659 (2001).
    • (2001) Genome Res. , vol.11 , pp. 1651-1659
    • Frazer, K.A.1
  • 10
    • 0037204994 scopus 로고    scopus 로고
    • A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome
    • Mural, R. J. et al. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science 296, 1661-1671 (2002).
    • (2002) Science , vol.296 , pp. 1661-1671
    • Mural, R.J.1
  • 11
    • 0036141877 scopus 로고    scopus 로고
    • Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome
    • DeSilva, U. et al. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res. 12, 3-15 (2002).
    • (2002) Genome Res. , vol.12 , pp. 3-15
    • DeSilva, U.1
  • 12
    • 0034616398 scopus 로고    scopus 로고
    • Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons
    • Loots, G. G. et al. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 286, 136-140 (2000).
    • (2000) Science , vol.286 , pp. 136-140
    • Loots, G.G.1
  • 13
    • 18544404720 scopus 로고    scopus 로고
    • Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution
    • Hardison, R. C. et al. Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution. Genome Res. 13, 13-26 (2003).
    • (2003) Genome Res. , vol.13 , pp. 13-26
    • Hardison, R.C.1
  • 14
    • 10744222156 scopus 로고    scopus 로고
    • Identification and characterization of multi-species conserved sequences
    • Margulies, E. H., Blanchette, M., Haussler, D. & Green, E. D. Identification and characterization of multi-species conserved sequences. Genome Res. 13, 2507-2518 (2003).
    • (2003) Genome Res. , vol.13 , pp. 2507-2518
    • Margulies, E.H.1    Blanchette, M.2    Haussler, D.3    Green, E.D.4
  • 15
    • 0034763055 scopus 로고    scopus 로고
    • Evolutionary conserved noncoding DNA in the human genome: How much and what for?
    • Meisler, M. H. Evolutionary conserved noncoding DNA in the human genome: how much and what for? Genome Res. 11, 1617-1618 (2001).
    • (2001) Genome Res. , vol.11 , pp. 1617-1618
    • Meisler, M.H.1
  • 16
    • 0041465867 scopus 로고    scopus 로고
    • Comparative analyses of multi-species sequences from targeted genomic regions
    • Thomas, J. W. et al. Comparative analyses of multi-species sequences from targeted genomic regions. Nature 424, 788-793 (2003).
    • (2003) Nature , vol.424 , pp. 788-793
    • Thomas, J.W.1
  • 17
    • 0037397918 scopus 로고    scopus 로고
    • GALA, a database for genomic sequence alignments and annotations
    • Giardine, B. et al. GALA, a database for genomic sequence alignments and annotations. Genome Res. 13, 732-741 (2003).
    • (2003) Genome Res. , vol.13 , pp. 732-741
    • Giardine, B.1
  • 18
    • 2442695243 scopus 로고    scopus 로고
    • Comparison of human chromosome 21 conserved non-genic sequences (CNGs) with the mouse and dog genomes shows that their selective constraint is independent of their genic environment
    • Dermitzakis, E. T. et al. Comparison of human chromosome 21 conserved non-genic sequences (CNGs) with the mouse and dog genomes shows that their selective constraint is independent of their genic environment. Genome Res. 14, 852-859 (2004).
    • (2004) Genome Res. , vol.14 , pp. 852-859
    • Dermitzakis, E.T.1
  • 19
    • 2542542256 scopus 로고    scopus 로고
    • Ultraconserved elements in the human genome
    • Bejerano, G. et al. Ultraconserved elements in the human genome. Science 304, 1321-1325 (2004).
    • (2004) Science , vol.304 , pp. 1321-1325
    • Bejerano, G.1
  • 20
    • 0142084743 scopus 로고    scopus 로고
    • Scanning human gene deserts for long-range enhancers
    • Nobrega, M. A., Ovcharenko, I., Afzal, V. & Rubin, E. M. Scanning human gene deserts for long-range enhancers. Science 302, 413 (2003).
    • (2003) Science , vol.302 , pp. 413
    • Nobrega, M.A.1    Ovcharenko, I.2    Afzal, V.3    Rubin, E.M.4
  • 21
    • 0141596080 scopus 로고    scopus 로고
    • The dog genome: Survey sequencing and comparative analysis
    • Kirkness, E. F. et al. The dog genome: survey sequencing and comparative analysis. Science 301, 1898-1903 (2003).
    • (2003) Science , vol.301 , pp. 1898-1903
    • Kirkness, E.F.1
  • 22
    • 0033799618 scopus 로고    scopus 로고
    • Active conservation of noncoding sequences revealed by three-way species comparisons
    • Dubchak, I. et al. Active conservation of noncoding sequences revealed by three-way species comparisons. Genome Res. 10, 1304-1306 (2000).
    • (2000) Genome Res. , vol.10 , pp. 1304-1306
    • Dubchak, I.1
  • 23
    • 1542347048 scopus 로고    scopus 로고
    • Noncoding sequences conserved in a limited number of mammals in the SIM2 interval are frequently functional
    • Frazer, K. A. et al. Noncoding sequences conserved in a limited number of mammals in the SIM2 interval are frequently functional. Genome Res. 14, 367-372 (2004).
    • (2004) Genome Res. , vol.14 , pp. 367-372
    • Frazer, K.A.1
  • 24
    • 0242662461 scopus 로고    scopus 로고
    • Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs)
    • Dermitzakis, E. T. et al. Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs). Science 302, 1033-1035 (2003).
    • (2003) Science , vol.302 , pp. 1033-1035
    • Dermitzakis, E.T.1
  • 25
    • 0344824015 scopus 로고    scopus 로고
    • Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents
    • Keightley, P. D. & Gaffney, D. J. Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents. Proc. Natl Acad. Sci. USA 100, 13402-13406 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 13402-13406
    • Keightley, P.D.1    Gaffney, D.J.2
  • 26
    • 0242410740 scopus 로고    scopus 로고
    • Evolution. Heirlooms in the attic
    • Johnston, M. & Stormo, G. D. Evolution. Heirlooms in the attic. Science 302, 997-999 (2003).
    • (2003) Science , vol.302 , pp. 997-999
    • Johnston, M.1    Stormo, G.D.2
  • 27
    • 18344415808 scopus 로고    scopus 로고
    • Distinguishing regulatory DNA from neutral sites
    • Elnitski, L. et al. Distinguishing regulatory DNA from neutral sites. Genome Res. 13, 64-72 (2003).
    • (2003) Genome Res. , vol.13 , pp. 64-72
    • Elnitski, L.1
  • 28
    • 0035986888 scopus 로고    scopus 로고
    • Evolution of transcription factor binding sites in mammalian gene regulatory regions: Conservation and turnover
    • Dermitzakis, E. T. & Clark, A. G. Evolution of transcription factor binding sites in mammalian gene regulatory regions: conservation and turnover. Mol. Biol. Evol. 19, 1114-1121 (2002).
    • (2002) Mol. Biol. Evol. , vol.19 , pp. 1114-1121
    • Dermitzakis, E.T.1    Clark, A.G.2
  • 29
    • 0037372327 scopus 로고    scopus 로고
    • A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions
    • Glazko, G. V., Koonin, E. V., Rogozin, I. B. & Shabalina, S. A. A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions. Trends Genet. 19, 119-124 (2003).
    • (2003) Trends Genet. , vol.19 , pp. 119-124
    • Glazko, G.V.1    Koonin, E.V.2    Rogozin, I.B.3    Shabalina, S.A.4
  • 30
    • 0033553877 scopus 로고    scopus 로고
    • Differences in the localization and morphology of chromosomes in the human nucleus
    • Croft, J. A. et al. Differences in the localization and morphology of chromosomes in the human nucleus. J. Cell Biol. 145, 1119-1131 (1999).
    • (1999) J. Cell Biol. , vol.145 , pp. 1119-1131
    • Croft, J.A.1
  • 31
    • 1842855742 scopus 로고    scopus 로고
    • Nuclear organization in differentiating oligodendrocytes
    • Nielsen, J. A., Hudson, L. D. & Armstrong, R. C. Nuclear organization in differentiating oligodendrocytes. J. Cell Sci. 115, 4071-4079 (2002).
    • (2002) J. Cell Sci. , vol.115 , pp. 4071-4079
    • Nielsen, J.A.1    Hudson, L.D.2    Armstrong, R.C.3
  • 32
    • 0037007044 scopus 로고    scopus 로고
    • Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates
    • Tanabe, H. et al. Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates. Proc. Natl Acad. Sci. USA 99, 4424-4429 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4424-4429
    • Tanabe, H.1
  • 33
    • 0025118536 scopus 로고
    • Transcriptional enhancers can act in trans
    • Muller, H. P. & Schaffner, W. Transcriptional enhancers can act in trans. Trends Genet. 6, 300-304 (1990).
    • (1990) Trends Genet. , vol.6 , pp. 300-304
    • Muller, H.P.1    Schaffner, W.2
  • 34
    • 0036957751 scopus 로고    scopus 로고
    • Transvection effects in Drosophila
    • Duncan, I. W. Transvection effects in Drosophila. Annu. Rev. Genet. 36, 521-556 (2002).
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 521-556
    • Duncan, I.W.1
  • 35
    • 2342485824 scopus 로고    scopus 로고
    • Does looping and clustering in the nucleus regulate gene expression?
    • Chambeyron, S. & Bickmore, W. A. Does looping and clustering in the nucleus regulate gene expression? Curr. Opin. Cell Biol. 16, 256-262 (2004).
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 256-262
    • Chambeyron, S.1    Bickmore, W.A.2
  • 36
    • 0242418246 scopus 로고    scopus 로고
    • Phylogenetic shadowing of primate sequences to find functional regions of the human genome
    • Boffelli, D. et al. Phylogenetic shadowing of primate sequences to find functional regions of the human genome. Science 299, 1391-1394 (2003).
    • (2003) Science , vol.299 , pp. 1391-1394
    • Boffelli, D.1
  • 37
    • 7244259100 scopus 로고    scopus 로고
    • Megabase deletions of gene deserts result in viable mice
    • Nobrega, M. A., Zhu, Y., Plajzer-Frick, I., Afzai, V. & Rubin, E. M. Megabase deletions of gene deserts result in viable mice. Nature 431, 988-993 (2004).
    • (2004) Nature , vol.431 , pp. 988-993
    • Nobrega, M.A.1    Zhu, Y.2    Plajzer-Frick, I.3    Afzai, V.4    Rubin, E.M.5
  • 38
    • 0021014396 scopus 로고
    • β-globin gene inactivation by DNA translocation in γ-β-thalassaemia
    • Kioussis, D., Vanin, E., deLange, T., Flavell, R. A. & Grosveld, F. G. β-Globin gene inactivation by DNA translocation in γ-β- thalassaemia. Nature 306, 662-666 (1983).
    • (1983) Nature , vol.306 , pp. 662-666
    • Kioussis, D.1    Vanin, E.2    DeLange, T.3    Flavell, R.A.4    Grosveld, F.G.5
  • 39
    • 0012953756 scopus 로고
    • γ-δ-β-Thalassemia due to a de novo mutation deleting the 5′ β-globin gene activation-region hypersensitive sites
    • Driscoll, M. C., Dobkin, C. S. & Alter, B. P. γ-δ-β- Thalassemia due to a de novo mutation deleting the 5′ β-globin gene activation-region hypersensitive sites. Proc. Natl Acad. Sci. USA 86, 7470-7474 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7470-7474
    • Driscoll, M.C.1    Dobkin, C.S.2    Alter, B.P.3
  • 40
    • 0042810698 scopus 로고    scopus 로고
    • A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly
    • Lettice, L. A. et al. A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly. Hum. Mol. Genet. 12, 1725-1735 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1725-1735
    • Lettice, L.A.1
  • 41
    • 0037188510 scopus 로고    scopus 로고
    • Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly
    • Lettice, L. A. et al. Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly. Proc. Natl Acad. Sci. USA 99, 7548-7553 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7548-7553
    • Lettice, L.A.1
  • 42
    • 0242363235 scopus 로고    scopus 로고
    • A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    • Van Laere, A. S. et al. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425, 832-836 (2003).
    • (2003) Nature , vol.425 , pp. 832-836
    • Van Laere, A.S.1
  • 43
    • 0031663782 scopus 로고    scopus 로고
    • Position effect in human genetic disease
    • Kleinjan, D. J. & van Heyningen, V. Position effect in human genetic disease. Hum. Mol. Genet. 7, 1611-1618 (1998).
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1611-1618
    • Kleinjan, D.J.1    Van Heyningen, V.2
  • 44
    • 0033662409 scopus 로고    scopus 로고
    • A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse
    • Bishop, C. E. et al. A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nature Genet. 26, 490-494 (2000).
    • (2000) Nature Genet. , vol.26 , pp. 490-494
    • Bishop, C.E.1
  • 45
    • 0030057538 scopus 로고    scopus 로고
    • Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9
    • Wirth, J. et al. Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9. Hum. Genet. 97, 186-193 (1996).
    • (1996) Hum. Genet. , vol.97 , pp. 186-193
    • Wirth, J.1
  • 46
    • 0036156544 scopus 로고    scopus 로고
    • Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma
    • Jamieson, R. V. et al. Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma. Hum. Mol. Genet. 11, 33-42 (2002).
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 33-42
    • Jamieson, R.V.1
  • 47
    • 0028789040 scopus 로고
    • A duplication/paracentric inversion associated with familial X-iinked deafness (DFN3) suggests the presence of a regulatory element more than 400 kb upstream of the POU3F4 gene
    • de Kok, Y. J. et al. A duplication/paracentric inversion associated with familial X-iinked deafness (DFN3) suggests the presence of a regulatory element more than 400 kb upstream of the POU3F4 gene. Hum. Mol. Genet. 4, 2145-2150 (1995).
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 2145-2150
    • De Kok, Y.J.1
  • 48
    • 10144238527 scopus 로고    scopus 로고
    • Identification of a hot spot for microdeletions in patients with X-linked deafness type 3 (DFN3) 900 kb proximal to the DFN3 gene POU3F4
    • de Kok, Y. J. et al. Identification of a hot spot for microdeletions in patients with X-linked deafness type 3 (DFN3) 900 kb proximal to the DFN3 gene POU3F4. Hum. Mol. Genet. 5, 1229-1235 (1996).
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1229-1235
    • De Kok, Y.J.1
  • 49
    • 0036209163 scopus 로고    scopus 로고
    • A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects
    • Spitz, F. et al. A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects. Genomics 79, 493-498 (2002).
    • (2002) Genomics , vol.79 , pp. 493-498
    • Spitz, F.1
  • 50
    • 18744421322 scopus 로고    scopus 로고
    • Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks approximately 90 kb upstream of this gene
    • Flomen, R. H. et al. Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks approximately 90 kb upstream of this gene. Genomics 47, 409-413 (1998).
    • (1998) Genomics , vol.47 , pp. 409-413
    • Flomen, R.H.1
  • 51
    • 0030753595 scopus 로고    scopus 로고
    • The TWIST gene, although not disrupted in Saethre-Chotzen patients with apparently balanced transiocations of 7p 21, is mutated in familial and sporadic cases
    • Rose, C. S., Patel, P., Reardon, W., Malcolm, S. & Winter, R. M. The TWIST gene, although not disrupted in Saethre-Chotzen patients with apparently balanced transiocations of 7p21, is mutated in familial and sporadic cases. Hum. Mol. Genet. 6, 1369-1373 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1369-1373
    • Rose, C.S.1    Patel, P.2    Reardon, W.3    Malcolm, S.4    Winter, R.M.5
  • 52
    • 0038613098 scopus 로고    scopus 로고
    • A global control region defines a chromosomal regulatory landscape containing the HoxD cluster
    • Spitz, F., Gonzalez, F. & Duboule, D. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell 113, 405-417 (2003).
    • (2003) Cell , vol.113 , pp. 405-417
    • Spitz, F.1    Gonzalez, F.2    Duboule, D.3
  • 53
    • 0035850725 scopus 로고    scopus 로고
    • Quantification of DNasel-sensitivity by real-time PCR: Quantitative analysis of DNasel-hypersensitivity of the mouse β-globin LCR
    • McArthur, M., Gerum, S. & Stamatoyannopoulos, G. Quantification of DNasel-sensitivity by real-time PCR: quantitative analysis of DNasel-hypersensitivity of the mouse β-globin LCR. J. Mol. Biol. 313, 27-34 (2001).
    • (2001) J. Mol. Biol. , vol.313 , pp. 27-34
    • McArthur, M.1    Gerum, S.2    Stamatoyannopoulos, G.3
  • 54
    • 10744226888 scopus 로고    scopus 로고
    • Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs
    • Cawley, S. et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 116, 499-509 (2004).
    • (2004) Cell , vol.116 , pp. 499-509
    • Cawley, S.1
  • 55
    • 4043128071 scopus 로고    scopus 로고
    • Genetic analysis of genome-wide variation in human gene expression
    • Morley, M. et al. Genetic analysis of genome-wide variation in human gene expression. Nature 430, 743-747 (2004).
    • (2004) Nature , vol.430 , pp. 743-747
    • Morley, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.