Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigs

Journal of Smooth Muscle Research

Volumn 41, Issue 5, 2005, Pages 257-270

  Takayama, Naomi ^a   Uchida, Kohsuke ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Airway smooth muscle; Lipopolysaccharide; Neutrophil elastase inhibitor; Sivelestat; Substance P

Indexed keywords

INDOMETACIN; LEUKOCYTE ELASTASE INHIBITOR; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; PROSTAGLANDIN; SIVELESTAT; SUBSTANCE P; TACHYKININ;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENDOTHELIUM INJURY; GUINEA PIG; MALE; NONHUMAN; PNEUMONIA; PROSTAGLANDIN SYNTHESIS INHIBITION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION; TRACHEA MUCOSA; TRACHEA MUSCLE;

ANIMALS; BRONCHI; GLYCINE; GUINEA PIGS; INDOMETHACIN; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM CHLORIDE; PROSTAGLANDINS; RESPIRATORY MUCOSA; RESPIRATORY SYSTEM; SERINE PROTEINASE INHIBITORS; SUBSTANCE P; SULFONAMIDES; TACHYKININS; TRACHEA;

EID: 31544454417     PISSN: 09168737     EISSN: 09168737     Source Type: Journal    
DOI: 10.1540/jsmr.41.257     Document Type: Article

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