The effects of tachykinins on inflammatory and immune cells

Regulatory Peptides

Volumn 70, Issue 2-3, 1997, Pages 75-90

  Maggi, Carlo Alberto ^a  

^a Menarini Ricerche SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TACHYKININ;

ANIMAL CELL; ANTIDROMIC STIMULATION; ASTROCYTE; DRUG EFFECT; GLIA CELL; GRANULOCYTE; HEMATOPOIESIS; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFLAMMATORY CELL; MAST CELL DEGRANULATION; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; HUMANS; IMMUNE SYSTEM; INFLAMMATION; TACHYKININS;

ANIMALIA;

EID: 0030791418     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(97)00029-3     Document Type: Review

References (198)

1. Erspamer V, Melchiorri P. Active polypeptides of the amphibian skin and their synthetic analogs. Pure Appl Chem 1973;35:463-94.
2. Maggi CA, Patacchini R, Rovero P, Giachetti A. Tachykinin receptors and tachykinin receptor antagonists. J Autonom Pharmacol 1993;13:23-93.
3. Otsuka M, Yoshioka K. Neurotransmitter function of mammalian tachykinins. Physiol Rev 1993;73:229-307.
4. Lembeck F. Zur Frage der zentralen Ubertragung afferenter Impulse III. Mitteilung. Das Vorkommen und die Bedeutung der Substanz P in den dorsalen Wurzeln des Ruckenmarks. Arch Exp Pathol Pharmakol 1953;219:197-213.
5. Jancso N, Jancso-Gabor A, Szolcsanyi J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol 1967;31:138-51.
6. Jancso N, Jancso-Gabor A, Szolcsanyi J. The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br J Pharmacol 1968;32:32-41.
7. Szolcsanyi J. Capsaicin and neurogenic inflammation: history and early findings. In: Chahl LA, Szolcsanyi J, Lembeck F, editors. Antidromic Vasodilatation and Neurogenic Inflammation. Budapest (Hungary): Akademiai Kiado, 1984a:7-25.
8. Maggi CA, Meli A. The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen Pharmacol 1988;19:1-43.
9. Maggi CA. Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog Neurobiol 1995;45:1-98.
10. Regoli D, Boudon A, Fauchere JL. Receptors and antagonists for substance P and related peptides. Pharmacol Rev 1994;46:551-99.
11. Maggi CA. The mammalian tachykinin receptors. Gen Pharmacol 1995;26:911-44.
12. Weihe E, Nohr D, Michel S, Muller S, Zentel HJ, Fink T, Krekel J. Molecular anatomy of the neuro-immune connection. Int J Neurosci 1991;59:1-23.
13. Felten SY, Felten DL, Bellinger DL, Olschowska JA. Noradrenergic and peptidergic innervation of lymphoid organs. In: Blalock JE, editor. Neuroimmunoendocrinology, Chemical Immunology. Basel (Switzerland): Karger, 1992:25-37.
14. Hukkanen M, Konttinen YT, Rees RG, Gibson SJ, Santavirta S, Polak JM. Innervation of bone from healthy and arthritic rats by SP and CGRP containing sensory fibers. J Rheumatol 1992;19:1252-9.
15. Hukkanen M, Konttinen YT, Rees RG, Santavirta S, Terenghi G, Polak JM. Distribution of nerve endings and sensory neuropeptides in rat synovium, meniscus and bone. Int J Tiss React 1992;14:1-10.
16. Yamazaki K, Allen TD. Ultrastructural morphometry study of efferent nerve terminals on murine bone marrow stromal cells and the recognition of a novel anatomical unit: the neuroreticular complex. Am J Anatomy 1990;187:261-72.
17. Fink T, Weihe E. Multiple neuropeptides in nerves supplying mammalian lymph nodes: messenger candidates for sensory and autonomic neuroimmunomodulation. Neurosci Lett 1988;90:39-44.
18. Weihe E, Muller S, Fink T, Zentel HJ. Tachykinins, CGRP and neuropeptide Y in nerves of the mammalian thymus: interactions with mast cells in autonomic and sensory neuroimmunomodulation?. Neurosci Lett 1989;100:77-82.
19. Weihe E, Nohr D, Muller S, Buchler M, Friess H, Zentel HJ. The tachykinin neuroimmune connection in inflammatory pain. Ann New York Acad Sci 1988;632:283-95.
20. Nilsson G, Alving K, Ahlstedt S, Hokfelt T, Lundberg JM. Peptidergic innervation of rat lymphoid tissue and lung: relation to mast cells and sensitivity to capsaicin and immunization. Cell Tiss Res 1990;262:125-33.
21. Lorton D, Bellinger DL, Felten SY, Felten DL. Substance P innervation of the rat thymus. Peptides 1990;11:1269-75.
22. Lorton D, Bellinger DL, Felten SY, Felten DL. Substance P innervation of spleen in rats: nerve fibres associated with lymphocytes and macrophages in specific compartments in the spleen. Brain Behav Immun 1991;5:29-40.
23. Elfvin LG, Aldskogius H, Johansson J. Splenic primary sensory afferents in the guinea-pig demonstrated with anterogradely transported wheat-germ agglutinin conjugated to horseradish peroxidase. Cell Tissue Res 1992;269:229-34.
24. Elfvin LG, Aldskogius H, Johansson J. Primary sensory afferents in the thymus of the guinea-pig demonstrated with anterogradely transported horseradish peroxidase conjugates. Neurosci Lett 1993;150:35-8.
25. Popper P, Mantyh CR, Vigna SR, Maggio JE, Mantyh PW. The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes. Peptides 1988;9:257-67.
26. Ericsson A, Geenen V, Robert F, Legros J, Vrindts-Gevaert Y, Franchimont P, Brene S, Persson H. Expression of preprotachykinin A and NPY-mRNA in the thymus. Mol Endocrinol 1990;4:1211-8.
27. Geppetti P, Maggi CA, Zecchi-Orlandini S, Santicioli P, Meli A, Frilli S, Spillantini MG, Amenta F. Substance P-like immunoreactivity in capsaicin-sensitive structures of the rat thymus. Regul Peptides 1987;18:321-9.
28. Geppetti P, Theodorsson-Norheim E, Ballerini G, Alessandri M, Maggi CA, Santicioli P, Amenta F, Fanciullacci M. Capsaicin-sensitive, tachykinin-like immunoreactivity in the thymus of rats and guinea-pigs. J Neuroimmunol 1988;19:3-10.
29. Maggi CA. The pharmacology of the efferent function of sensory nerves. J Autonom Pharmacol 1991;11:173-208.
30. Linnick MD, Moskowitz MA. Identification of immunoreactive Substance P in human and other mammalian endothelial cells. Peptides 1989;10:957-65.
31. Ralevic V, Milner P, Hudlicka O, Kristeck F, Burnstock G. Substance P is released from the endothelium of normal and capsaicin-treated rat hindlimb vasculature, in vivo, by increased flow. Circ Res 1990;65:1178-89.
32. Aliakbar J, Sreedharan SP, Turck CW, Goetzl EJ. Selective localization of VIP and substance P in human eosinophils. Biochem Biophys Res Commun 1987;188:1440-5.
33. Weinstock JV, Slum A, Walder J, Walder R. Eosinophils from granulomas in murine Schistosomiasis mansoni produce substance P. J Immunol 1988;141:961.
34. Hartung HP, Wolters K, Toyka KV. Substance P: binding properties and studies on cellular responses in guinea-pig macrophages. J Immunol 1986;135:3856-64.
35. Pascual DW, Bost KL. Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide. Immunology 1990;71:52-6.
36. Bost KL, Breeding SAL, Pascual DW. Modulation of the mRNAs encoding SP and its receptor in rat macrophages by LPS. Reg Immunol 1992;4:105-12.
37. Weinstock JV, Blum AM. Tachykinin production in granulomas of murine Schistosomiasis mansoni. J Immunol 1989;142:3256-61.
38. Weinstock JV, Blum AM. Release of Substance P by granuloma eosinophils in response to secretagogues in murine Schistosomiasis mansoni. Cell Immunol 1990;125:380-5.
39. Bost KL. Inducible preprotachykinin mRNA expression in mucosal lymphoid organs following oral immunization with Salmonella. J Neuroimmunol 1995;62:59-67.
40. Pernow B. Substance P 1983;35:85-141.
41. Moore RN, Osmand AP, Dunn JA, Joshi JG, Rouse BT. Substance P augmentation of CSF-1 stimulated in vitro myelopoiesis. J Immunol 1988;141:2699-703.
42. Rameshwar P, Ganea D, Gascon P. In vitro stimulatory effect of substance P on hematopoiesis. Blood 1993;81:391-8.
43. Rameshwar P, Ganea D, Gascon P. Induction of interleukin-3 and GM-CSF by substance P in bone marrow cells is partially mediated through the release of IL-1 and IL-6. J Immunol 1994; 152:4044-54.
44. Rameshwar P, Gascon P. Substance P mediates production of stem cell factor and Interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction. Blood 1995;86:482-90.
45. Rameshwar P, Gascon P. Induction of negative hematopoietic regulators by neurokinin A in bone marrow stroma. Blood 1996;88:98-106.
46. McDonald D. Neurogenic inflammation in the rat trachea. I. Changes in venules, leucocytes and epithelial cells. J Neurocytol 1988;17:583-603.
47. Sagara H, Yukawa T, Arima M, Terashi Y, Yoshihara S, Abe T, Ichimura T, Makino S. Capsaicin and substance P induce eosinophil infiltration in bronchi in guinea-pigs. Am Rev Resp Dis 1991;143:A616.
48. Hsiue TR, Garland A, Ray DW, Hershenson MB, Leff AR, Solway J. Endogenous sensory neuropeptides release enhances nonspecific airway responsiveness in guinea-pigs. Am Rev Resp Dis 1992;146:148-53.
49. Kudlacz EM, Knippenberg RW. In vitro and in vivo effects of tachykinins on immune cell function in guinea-pig airways. J Neuroimmunol 1994;50:119-25.
50. 1 receptors mediate leukocyte adhesion in neurogenic inflammation in the rat trachea. Am J Physiol 1995;268:L263-9.
51. 1 receptor antagonists and the role of endogenous mediators. Br J Pharmacol 1995;114:1343-50.
52. Matsuda H, Kawakita K, Kiso Y, Nakano T, Kitamura Y. Substance P induces granulocyte infiltration through degranulation of mast cells. J Immunol 1989;142:927-31.
53. Yano H, Wershil BK, Arizono N, Galli SJ. Substance P-induced augmentation of cutaneous vascular permeability and granulocyte infiltration in mice is mast cell dependent. J Clin Invest 1989;84:1276-86.
54. 1 receptors. J Immunol 1993;80:73-7.
55. Ohlen A, Lindblom L, Staines W, Hokfelt T, Cuello AC, Fisher JA, Hedkvist P. Substance P and CGRP: immunohistochemical localization and microvascular effects in rabbit skeletal muscle. Naunyn Schmiedeberg's Arch Pharmacol 1987;336:87-93.
56. Ohlen A, Thureson-Klein A, Lindbom L, Persson MG, Hedqvist P. Substance P activates leucocytes and platelets in rabbit microvessels. Blood Vessels 1989;26:84-94.
57. Marasco WA, Showell HJ, Becker EL. Substance P binds to the formylpeptide chemotaxis receptor on the rabbit neutrophil. Biochem Biophys Res Commun 1981;99:1065-72.
58. Roch-Arveiller M, Regoli D, Chanaud B, Lenoir M, Muntaner O, Stralzko S, Giroud JP. Tachykinins: effects on motility and metabolism of rat polymorphonuclear leucocytes. Pharmacol 1986;33:266-73.
59. Wiedermann CJ, Wiedermann FJ, Apperl A, Kieselbach G, Konwalinka G, Braunsteiner H. In vitro polymorphonuclear leukocyte chemokinesis and human monocyte chemotaxis are different activities of N-terminal and C-terminal SP. Naunyn Schmiedebergs Arch Pharmacol 1989;340:185-90.
60. Carolan EJ, Casale TB. Effects of neuropeptides on neutrophil migration through noncellular and endothelial barriers. J Allergy Clin Immunol 1993;92:589-98.
61. Serra MC, Bazzoni F, Della Bianca V, Greskowiak M, Rossi F. Activation of human neutrophils by substance P. Effect on oxidative metabolism exocytosis, cytosolic calcium concentration and inositol phosphate formation. J Immunol 1988;141:2118-24.
62. Brunelleschi S, Ceni E, Giotti A, Fantozzi R. Tachykinins stimulate lyso-PAF: acetyl CoA acetyltransferase activity in neutrophils. Eur J Pharmacol 1990;186:367-8.
63. Wozniak A, Betts WH, McLennan G, Scicchitano R. Activation of human neutrophils by tachykinins, effects on FMLP and PAF-stimulated superoxidse anion production and antibody-dependent cell-mediated cytotoxicity. Immunology 1993;78:629-34.
64. Serra MC, Calzetti F, Ceska M, Cassatella MA. Effect of substance P on superoxide anion and IL-8 production by human PMNL. Immunology 1994;82:63-9.
65. Perianin A, Snyderman R, Malfroy B. Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation. Biochem Biophys Res Commun 1989;161:520-4.
66. Wiedermann CJ, Niedermuhlbichler M, Zilian U, Geissler D, Lindley I, Braunsteiner H. Priming of normal human neutrophils by tachykinins: tuftsin-like inhibition of in vitro chemotaxis stimulated by formylpeptide or interleukin-8. Regul Peptides 1991;36:359-68.
67. El-Shazly AE, MAsuyama K, Eura M, Ishikawa T. Immunoregulatory effect of substance P on human eosinophil migratory function. Immunol Invest 1996;25:191-201.
68. Tanabe T, Otani H, Bao L, Mikami Y, Yasukura T, Ninomiya T, Ogawa R, Inagaki C. Intracellular signalling pathway of SP-induced superoxide production in human neutrophils. Eur J Pharmacol 1996;299:187-95.
69. Malik AB, Lo SK. Vascular endothelial adhesion molecules and tissue inflammation. Pharmacol Rev 1996;48:213-29.
70. Matis WL, Lavker RM, Murphy GF. Substance P induces the expression of endothelial-leukocyte adhesion molecule by microvascular endothelium. J Invest Dermatol 1990;94:492-5.
71. Smith CH, Barker JNWN, Morris RW, MacDonald DM, Lee TH. Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin. J Immunol 1993;151:3274-82.
72. Nakagawa N, Sano H, Iwamoto I. Substance P induces the expression of intercellular adhesion molecule-1 on vascular endothelial cell and enhances neutrophil transendothelial migration. Peptides 1995;16:721-5.
73. Zimmerman BJ, Anderson DC, Granger DN. Neuropeptides promote neutrophil adherence to endothelial cell monolayers. Am J Physiol 1992;263:G678-82.
74. Shipp MA, Stefano GB, Switzer SN, Griffin JD, Reinherz EL. CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology, migration and adhesion proteins and is itself regulated by neutrophil activation. Blood 1991;78:1834-41.
75. Umeno E, Nadel JA, Huang HT, McDonald DM. Inhibition of neutral endopeptidase potentiates neurogenic inflammation in the rat trachea. J Appl Physiol 1989;66:2647-52.
76. Umeno E, Nadel JA, McDonald DM. Neurogenic inflammation of the rat trachea: fate of neutrophils that adhere to venules. J Appl Physiol 1990;69:2131-6.
77. Von Essen SG, Rennard SI, O'Neill D, Ertl RF, Robbins RA, Koyama S, Rubinstein I. Bronchial epithelial cells release neutrophil chemotactic activity in response to tachykinins. Am J Physiol 1992;263:L226-231.
78. De Rose V, Robbins RA, Snider RM, Spurzem JR, Thiele GM, Rennard SI, Rubinstein I. Substance P increases neutrophil adhesion to bronchial epithelial cells. J Immunol 1994;152:1339-46.
79. 1 receptor antagonist CP 99994 inhibits cigarette smoke-induced neutrophil and eosinophil adhesion in rat tracheal venules. Exp Lung Res 1996;22:409-18.
80. Maggi CA, Giachetti A, Dey RD, Said SI. Neuropeptides as regulators of airway function: with special reference to VIP and the tachykinins. Physiol Rev 1995;75:277-322.
81. Bozic CR, Lu B, Hopken UE, Gerard C, Gerard NP. Neurogenic amplification of immune complex inflammation. Science 1996;273:1722-5.
82. Suzuki H, Miura S, Liu YY, Tsuchiya M, Ishii H. Substance P induces degranulation of mast cells and leukocyte adhesion to venular endothelium. Peptides 1995;16:1447-52.
83. Iwamoto I, Tomoe S, Tomioka H, Yoshida N. Leukotriene B4 mediates substance P-induced granulocyte infiltration into mouse skin. J Immunol 1995;151:2116-23.
84. Norris AA, Leeson ME, Jackson DM, Holroyde MC. Modulation of neurogenic inflammation in rat trachea. Pulm Pharmacol 1991;3:180-4.
85. Woie K, Koller ME, Heyeraas KJ, Reed RK. Neurogenic inflammation in rat trachea is accompanied by increased negativity of interstitial fluid pressure. Circ Res 1993;73:849-55.
86. Germonpre' PR, Joos GF, Everaert E, Kips JC, Pauwels RA. Characterization of neurogenic inflammation in the airways of two highly inbred rat strains. Am J Resp Crit Care Med 1995;152:1796-804.
87. Payan DG, Brewster DR, Goetzl EJ. Stereospecific receptors for SP on cultured human IM9 lymphoblasts. J Immunol 1984;133:3260-5.
88. Payan DG, McGillis JP, Organist ML. Binding characteristics and affinity labeling of protein constituents of the human IM-9 lymphoblast receptor for SP. J Biol Chem 1986;261:14321-9.
89. Payan DG, Brewster DR, Missirian-Bastian A, Goetzl EJ. Substance P recognition of a subset of human T lymphocytes. J Clin Invest 1984;74:1532-9.
90. Stanisz A, Scicchitano P, Dazin J, Bienenstock J, Payan DG. Distribution of substance P receptors on murine spleen and Peyer's patch T and B cells. J Immunol 1987;139:749-54.
91. Roberts AI, Taunk J, Ebert EC. Human lymphocyets lack substance P receptors. Cell Immunol 1992;141:457-65.
92. Kavelaars A, Jeurissen F, Heijnen CJ. Substance P receptors and signal transduction in leucocytes. Immunomethods 1994;5:41-8.
93. 1) receptor. J Immunol 1994;152:1830-5.
94. Kavelaars A, Jeurissen F, von Frijtag Drabbe Kunzel J, van Roijen JH, Rijkers GT, Heijnen CJ. Substance P induces a rise in intracellular calcium concentration in human T lymphocytes in vitro: evidence of a receptor independent mechanism. J Neuroimmunol 1994;42:61-70.
95. Casini A, Geppetti P, Maggi CA, Surrenti C. Effects of CGRP, NKA and NKA(4-10) on the mitogenic response of human peripheral blood mononuclear cells. Naunyn Schmiedeberg's Arch Pharmacol 1989;339:354-8.
96. Calvo CF, Chavanel G, Senik A. Substance P enhances IL-2 expression in activated human T cells. J Immunol 1992;148:3498-504.
97. Rameshwar P, Gascon P, Ganea D. Stimulation of IL-2 production in murine lymphocytes by substance P and related tachykinins. J Immunol 1993;151:2484-96.
98. Heerwagen C, Pabst R, Westermann J. The neuropeptide substance P does not influence the migration of B,T, CD8 + and CD4 + (naive and memory) lymphocytes from blood to lymph in the normal rat. Scand J Immunol 1995;42:480-6.
99. Bost KL, Pascual DW. Substance P: a late-acting B lymphocyte differentiation cofactor. Am J Physiol 1992;262:C537-45.
100. Pascual DW, Xu-Amano J, Kiyono H, McGhee JR, Bost KL. Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production. J Immunol 1991;146:2130-6.
101. Helme RD, Eglezos A, Dandie GW, Andrews PW, Boyd RL. The effect of substance P on the regional lymph node antibody response to antigenic stimulation in capsaicin-pretreated rats. J Immunol 1987;139:3470-3.
102. Eglezos A, Andrews PV, Boyd RL, Helme RD. Effects of capsaicin treatment on immunoglobulin secretion in the rat: further evidence for involvement of tachykinin-containing afferents. J Neuroimmunol 1990;26:131-8.
103. Eglezos A, Andrews PV, Boyd RL, Helme RD. Tachykinin-mediated modulation of the primary antibody response in rats: evidence for mediation by an NK-2 receptor. J Neuroimmunol 1991;32:11-8.
104. Scicchitano R, Bienenstock J, Stanisz AM. In vivo immunomodulation by the neuropeptide Substance P. Immunology 1988;63:733-5.
105. Ijaz MK, Dent D, Babiuk LA. Neuroimmunomodulation of in vivo anti-rotavirus humoral immune response. J Neuroimmunol 1990;26:159-71.
106. 1) receptor. J Immunol 1994;152:1830-5.
107. Blum A, Metwali A, Elliott D, Sandor M, Lynch R, Weinstock JV. Substance P receptor antagonist inhibits murine IgM expression in developing schistosome granulomas by blocking the terminal differentiation of intragranuloma B cells. J Neuroimmunol 1996;66:1-10.
108. Carucci JA, Herrick CA, Durkin HG. Neuropeptide-mediated regulation of hapten-specific IgE responses in mice. II Mechanisms of substance P-mediated isotype-specific suppression of BPO-specific IgE antibody-forming cell responses induced in vitro. J Neuroimmunol 1994;49:89-95.
109. Agro A, Stanisz AM. Are lymphocytes a target for substance P modulation arthritis?. Semin Arthritis Rheumatism 1992;21:252-8.
110. Covas MJ, Pinto LA, Pereira da Silva JA, Victorino RMM. Effects of the neuropeptide susbtance P on lymphocyte proliferation in rheumatoid arthritis. J Int Med Res 1995;23:431-8.
111. Yokoyama MM, Fujimoto K. Role of lymphocyte activation by substance P in rheumatoid arthritis. Int J Tissue React 1990;12:1-9.
112. Covas MJ, Pinto LA, Victorino RMM. Disturbed immunoregulatory properties of the neuropeptide substance P on lymphocyte proliferation in HIV patients. Clin Exp Immunol 1994;96:384-8.
113. Shigematsu K, Saavedra MJ, Kurihara M. Specific SP binding sites in rat thymus and spleen: in vitro autoradiographic study. Regul Peptides 1996;16:147-56.
114. 1 receptor type autoradiographically associated with vascular sinuses and high endothelial venules of human lymphoid tissues. Lab Invest 1993;69:86-93.
115. Mantyh CR, Gates TS, Zimmermann RP, Welton ML, Passaro EP, Vigna SR, Maggio JE, Kruger L, Mantyh PW. Receptor binding sites for SP but not substance K or neuromedin K are expressed in high concentrations by arterioles, venules and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proc Natl Acad Sci USA 1988;85:3235-9.
116. Mantyh PW, Mantyh CR, Gates T, Vigna SR, Maggio JE. Receptor binding sites for SP and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease. Neuroscience 1988;25:817-37.
117. Mantyh PW, Catton MD, Boehmer CG, Welton ML, Passaro EP, Maggio JE, Vigna SR. Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. Peptides 1989;10:627-45.
118. Stein M, Keshav S. The versatility of macrophages. Clin Exp Allergy 1992;22:19-27.
119. Lotz M, Vaughan JH, Carson DA. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 1988;241:1218-21.
120. Laurenzi MA, Persson MAA, Dalsgaard CJ, Haegerstrand A. The neuropeptide substance P stimulates production of interleukin-1 in human blood monocytes: activated cells are preferentially influenced by the neuropeptide. Scand J Immunol 1990;31:529-34.
121. Lee HR, Ho W, Douglas SD. Substance P augments tumor necrosis factor release in human monocyte-derived macrophages. Clin Diagn Lab Immunol 1994;1:419-23.
122. Lieb K, Fiebich BL, Busse-Grawitz M, Hull M, Berger M, Bauer J. Effects of substance P and selected other neuropeptides on the synthesis of interleukin 1b and interleukin-6 in human monocytes: a re-examination. J Neuroimmunol 1996;67:77-81.
123. Jeurissen F, Kavelaars A, Korstjens M, Broeke D, Franklin RA, Gelfand EW, Heijnen CJ. Monocytes express a non-neurokinin substance P receptor that is functionally coupled with MAP kinase. J Immunol 1994;152:2987-94.
124. Kavelaars A, Broeke D, Jeurissen F, Kardux J, Meijer A, Franklin R, Gelfand EW, Heijnen CJ. Activation of human monocytes via a non-neurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase and IL-6 production. J Immunol 1994;153:3691-9.
125. Ho WZ, Cnaan A, Li YH, Zhao H, Lee HR, Song L, Douglas SD. Substance P modulates HIV replication in human peripheral blood monocyte derived macrophages. AIDS Res Human Retroviruses 1996;12:195-8.
126. Hartung HP, Wolters K, Toyker KV. Substance P: binding properties and studies on cellular responses in guinea-pig macrophages. J Immunol 1986;136:3856-63.
127. Kincy-Cain T, Bost KL. Increased susceptibility of mice to Salmonella infection following in vivo treatment with the SP antagonist Spantide II. J Immunol 1996;157:255-64.
128. Kimball SE, Persico FJ, Vaught JL. Substance P, neurokinin A and neurokinin B induce generation of interleukin-1-like activity by P388D1 cells. J Immunol 1988;141:3564-9.
129. Cook GA, Blum AM, Ballas Z, Weinstock JV. Substance P does not alter interleukin-1 expression by splenic or granuloma macrophages in murine schistosomiasis. J Neuroimmunol 1991;33:215-25.
130. 1 receptors. Br J Pharmacol 1990;100:417-20.
131. 2B-like receptors in guinea-pig alveolar macrophages. Life Sci Pharmacol Lett 1992;51:PL177-181.
132. Brunelleschi S, Parenti A, Ceni E, Giotti A, Fantozzi R. Enhanced responsiveness of ovalbumin-sensitized guinea-pig alveolar macrophages to tachykinins. Br J Pharmacol 1992;107:964-9.
133. Murris-Espin M, Pinelli E, Pipy B, Leophonte P, Didier A. Substance P and alveolar macrophages: effects on oxidative metabolism and eicosanoid production. Allergy 1995;50:334-9.
134. Brunelleschi S, Guidotto S, Viano I, Fantozzi R, Pozzi E, Ghio P, Albera C. Tachykinin activation of human alveolar macrophages in tobacco smoke and sarcoidosis: a phenotypical and functional study. Neuropeptides 1996;30:456-64.
135. Brunelleschi S, Guidotto S, Tonso E, Viano I, Fantozzi R. Modulation by protein kinase C of the enhanced responsiveness to tachykinins in ovalbumin-sensitized guinea-pig alveolar macrophages. Neuropeptides 1996;30:249-60.
136. Kudlacz EM, Knippenberg RW. In vitro and in vivo effects of tachykinins on immune cell function in guinea-pig airways. J Neuroimmunol 1994;50:119-25.
137. Rankin JA. The contribution of alveolar macrophages to hyperreactive airway disease. J Allergy Clin Immunol 1989;83:722-9.
138. Nohr D, Weihe E. Tachykinin-CGRP- and protein gene product 9.5-immunoreactive nerve fibers in alveolar wall of mammals. Neurosci Lett 1991;134:17-20.
139. Boichot E, Lagente V, Paubert-Braquet M, Frossard N. Inhaled SP induces activation of alveolar macrophages and increases airway responses in the guinea-pig. Neuropeptides 1993;25:307-13.
140. 2 receptors. Am J Physiol 1995;269:L631-6.
141. Benveniste EN. Inflammatory cytokines within the central nervous system: sources, function and mechanism of action. Am J Physiol 1992;263:C1-C16.
142. 1 type (substance P) coupled positively with phospholipase C on cortical astrocytes from the newborn mouse in primary culture. J Neurochem 1989;52:1913-8.
143. Hartung HP, Heininger K, Schafer B, Toyka KV. Substance P and astrocytes: stimulation of the cyclooxygenase pathway of arachidonic acid metabolism. FASEB J 1988;2:48-51.
144. Wienrich M, Kettenman H. Activation of substance P receptors leads to membrane potential responses in cultured astrocytes. Glia 1989;2:155-60.
145. Martin FC, Charles AC, Sanderson MJ, Merrill JE. Substance P stimulates IL-1 production by astrocytes via intracellular calcium. Brain Res 1992;599:13-8.
146. Mantyh PW, Johnson DJ, Boehmer CG, Catton MD, Vinters HV, Maggio JE, Too HP, Vigna SR. Substance P receptor binding sites are expressed by glia in vivo after neuronal injury. Proc Natl Acad Sci USA 1989;86:5193-7.
147. Kostyk SK, Kowall NW, Hauser SL. Substance P immunoreactive astrocytes are present in multiple sclerosis plaques. Brain Res 1989;504:284-8.
148. Lee CM, Kum W, Cockram CS, Teoh R, Young JD. Functional Substance P receptors on a human astrocytoma cell line (U 373 MG). Brain Res 1989;488:328-31.
149. Johnson CL, Johnson CG. Characterization of receptors for substance P in human astrocytoma cells: radioligand binding and inositol phosphate formation. J Neurochem 1992;58:471-7.
150. 1 tachykinin receptor in the astrocytoma cell line U 373 MG. J Neurochem 1993;60:868-76.
151. 1 receptor antagonists of substance P and septide-induced IL-6 release from U373 MG human astrocytoma cell line. Neurosci Lett 1994;171:221-4.
152. Henning IM, Laissue JA, Horisberger U, Reubi JC. Substance P receptors in human primary neoplasms: tumoral and vascular localizations. Int J Cancer 1995;61:786-92.
153. Luo W, Sharif TR, Sharif M. Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signalling pathway. Cancer Res 1996;56:4983-91.
154. Perry VH, Gordon S. Macrophages and microglia in the nervous system. Trends Neurosci 1988;11:273-7.
155. 1 receptor. J Neuroimmunol 1993;42:53-7.
156. Luber-Narod J, Kage R, Leeman SE. Substance P enhances the secretion of tumor necrosis factor-a from neuroglial cells stimulated with lipopolysaccharide. J Immunol 1994;152:819-24.
157. Johnson AR, Erdos EG. Release of histamine from mast cells by vasoactive agents. Proc Soc Exp Biol Med 1973;142:1252-6.
158. Foreman JC, Jordan CC, Oehme P, Renner H. Structure-activity relationships for some SP-related peptides that cause wheal and flare reactions in human skin. J Physiol (London) 1983;335:449-65.
159. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, CGRP and other neuropeptides. Neuroscience 1988;24:739-68.
160. Skofitsch G, Savitt JM, Jacobowitz DM. Suggestive evidence for a functional unit between mast cells and substance P fibers in the rat diaphragm and mesentery. Histochemistry 1985;82:5-8.
161. Stead RH, Tomioka M, Quinonez G, Simon GT, Felten SY, Bienenstock J. Intestinal mucosa mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves. Proc Natl Acad Sci USA 1987;84:2975-9.
162. Renda T, Vaccaro R, Casu C. CGRP-LI nerve endings in rat knee joint. Ann New York Acad Sci 1992;657:484-5.
163. Dimitriadou V, Rouleau A, Trung Tuong MD, Newlands GJF, Miller HRP, Luffau G, Schwartz JC, Garbarg M. Functional relationship between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions. Neuroscience 1997;77:829-39.
164. Alving K, Sundstrom C, Matran R, Panula P, Hokfelt T, Lundberg JM. Association between histamine-containing mast cells and sensory nerves in the skin and control and capsaicin-treated pigs. Cell Tissue Res 1991;264:529-38.
165. Bienenstock J, McQueen G, Sestini P, Marshall JS, Stead RH, Perdue MH. Mast cell/nerve interactions in vitro and in vivo. Am Rev Resp Dis 1991;143:S55-8.
166. Shibata H, Mio M, Tasaka K. Analysis of the mechanism of histamine release by SP. Biochim Biophys Acta 1985;846:1-7.
167. Repke H, Bienert M. Structural requirements for mast cells triggering by SP-like peptides. Agents Actions 1988;23:207-10.
168. Arock M, Devillier P, Luffau G, Guillosson JJ, Renoux M. Histamine-releasing activity of endogenous peptides on mast cells derived from different sites and species. Int Arch Allergy Appl Immunol 1989;89:229-35.
169. 25-induced mediator release from different mast cells subtypes of rat and guinea-pig. Immunopharmacology 1989;17:119-28.
170. Devillier P, Regoli D, Asseraf A, Descours B, Marsac J, Renoux M. Histamine release and local responses of rat and human skin to SP and other mammalian tachykinins. Pharmacology 1986;32:340-7.
171. Devillier P, Drapeau G, Renoux M, Regoli D. Role of the N-terminal arginine in the histamine-releasing activity of SP, bradykinin and related peptides. Eur J Pharmacol 1989;168:53-60.
172. Pearce FL, Kassessinoff TA, Liu WL. Characteristics of histamine secretion induced by neuropeptides: implications for the relevance of peptide-mast cell interactions in allergy and inflammation. Int Arch Allergy Appl Immunol 1989;88:129-31.
173. Mousli M, Bueb JL, Bronner C, Rouot B, Landry YG. Protein activation: a receptor independent mode of action for cationic amphiphilic neuropeptides and venom peptides. Trends Pharmacol Sci 1990;11:358-62.
174. Columbo M, Horowitz EM, Sobotka AK, Lichtenstein LM. Substance P activates the release of histamine from human skin mast cells through a pertussis toxin-sensitive and protein kinase C dependent mechanism. Clin Immunol Immunopathol 1996;81:68-73.
175. Penner R, Matthews G, Neher E. Regulation of calcium influx by second messengers in rat mast cells. Nature (London) 1988;334:499-504.
176. Matthews G, Neher E, Penner R. Chloride conductance activated by external agonists and internal messengers in rat peritoneal mast cells. J Physiol (London) 1989;418:131-44.
177. Janiszewski J, Bienenstock J, Blennerhassett MG. Picomolar doses of substance P trigger electrical responses in mast cells without degranulation. Am J Physiol 1994;267:C138-45.
178. 2 tachykinin receptors and their involvement in histamine release in a murine mast cell line. Neuropeptides 1992;21:65-72.
179. Krumins SA, Bloomfield CA. C-terminal substance P fragments elicit histamine release from a murine mast cell line. Neuropeptides 1993;24:5-10.
180. Ansel JC, Brown JR, Payan DG, Brown MA. Substance P selectively increases TNFα gene expression in murine mast cells. J Immunol 1993;150:4478-85.
181. Tam EK, Aufderheide J, Hua XY. Chymotryptic activity in perfusates of isolated rat trachea: correlation with mucosal and connective tissue mast cell secretion. Am J Resp Cell Mol Biol 1994;11:321-8.
182. Hua XY, Back SM, Tam EK. Substance P enhances electrical field stimulation-induced mast cell degranulation in rat trachea. Am J Physiol 1996;270:L985-91.
183. Hagermark O, Hokfelt T, Pernow B. Flare and itch induced by Substance P in human skin. J Invest Dermatol 1978;71:233-5.
184. Coutts AA, Jorizzo JJ, Greaves MW, Burnstock G. Mechanism of vasodilatation due to Substance P in humans. Br J Dermatol 1981;105:354-5.
185. Jacques L, Couture R, Drapeau G, Regoli D. Capillary permeability induced by intravenous neurokinins, receptor characterization and mechanism of action. Naunyn Schmiedeberg's Arch Pharmacol 1989;340:170-9.
186. Abelli L, Nappi F, Perretti F, Maggi CA, Manzini S, Giachetti A. Microvascular leakage induced by Substance P in rat urinary bladder: involvement of cyclooxygenase metabolites of arachidonic acid. J Autonom Pharmacol 1992;12:269-76.
187. Lam FY, Ferrell WR. Mediators of Substance P induced inflammation in the rat knee joint. Agents Actions 1990;31:298-307.
188. Kiernan JA. The involvement of mast cells in vasodilatation to axon reflex in injured skin. Q J Exp Physiol 1972;57:311-8.
189. Kiernan JA. Study of chemically induced acute inflammation in the skin of the rat. Q J Exp Physiol 1973;62:151-6.
190. Dimitriadou V, Buzzi MG, Moskowitz MA, Theoharides TC. Trigeminal sensory fibers stimulation induces morphological changes reflecting secretion in rat dura mater mast cells. Neuroscience 1991;44:97-112.
191. Markowitz S, Saito K, Moskowitz MA. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J Neurosci 1987;7:4129-36.
192. Kowalski ML, Kaliner M. Neurogenic inflammation, vascular permeability and mast cells. J Immunol 1988;140:3905-12.
193. Kowalski ML, Sliwinska-Kowalska M, Kaliner M. Neurogenic inflammation, vascular permeability and mast cells. II Additional evidence indicating that mast cells are not involved in neurogenic inflammation. J Immunol 1988;145:1214-21.
194. Tausk F, Undem B. Exogenous but not endogenous substance P releases histamine from isolated human skin fragments. Neuropeptides 1995;29:351-5.
195. Wallace JL, McKnight GW, Befus AD. Capsaicin-induced hyperaemia in the stomach: possible contribution of mast cells. Am J Physiol 1992;263:G209-14.
196. Mathison R, Davison JS. Vasodilation in jejunal arterioles induced by primary afferent nerves in sensitized rats is mast cell dependent. J Autonom Nervous System 1993;43(Supplement):93-4.
197. Blum AM, Metwali A, Cook G, Mathew RC, Elliott D, Weinstock JV. Substance P modulates antigen-induced IFN-γ production in murine Schistosomiasis mansoni. J Immunol 1993;151:225-33.
198. 1 receptors. J Neuroimmunol 1996;65:119-24.