Signalling by the type 1 insulin-like growth factor receptor: Interplay with the epidermal growth factor receptor

Growth Factors

Volumn 22, Issue 2, 2004, Pages 89-95

  Adams, Timothy E ^a,b   McKern, Neil M ^a,b   Ward, Colin W ^a,b  

^a CSIRO   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Epidermal growth factor; Insulin like growth factors (IGFs); Ligands; Signalling

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CELL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; MEMBRANE ENZYME; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN RECEPTOR; TRASTUZUMAB;

CANCER CHEMOTHERAPY; CANCER RESISTANCE; DEVELOPMENT; DRUG POTENCY; DRUG TARGETING; GROWTH; HUMAN; MAMMAL; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; SHORT SURVEY; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LIGANDS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; TYROSINE;

MAMMALIA;

EID: 3142690018     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.1080/08977190410001700998     Document Type: Short Survey

References (59)

1. Adams, T.E., Epa, V.C., Garrett, T.P. and Ward, C.W. (2000) "Structure and function of the type 1 insulin-like growth factor receptor", Cell Mol. Life Sci. 57, 1050-1093.
2. Ahmad, T., Farnie, G., Bundred, N.J. and Anderson, N.G. (2004) "The mitogenic action of insulin-like growth factor I in normal human mammary epithelial cells requires the epidermal growth factor receptor tyrosine kinase", J. Biol. Chem. 279, 1713-1719.
3. Awwad, R.A., Sergina, N., Yang, H., Ziober, B., Willson, J.K., Zborowska, E., Humphrey, L.E., Fan, R., Ko, T.C., Brattain, M.G. and Howell, G.M. (2003) "The role of transforming growth factor alpha in determining growth factor independence", Cancer Res. 63, 4731-4738.
4. Baker, J., Liu, J.P., Robertson, E.J. and Efstratiadis, A. (1993) "Role of insulin-like growth factors in embryonic and postnatal growth", Cell 75, 73-82.
5. Balana, M.E., Labriola, L., Salatino, M., Movsichoff, F., Peters, G., Charreau, E.H. and Elizalde, P.V. (2001) "Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells", Oncogene 20, 34-47.
6. Baserga, R. (1994) "Oncogenes and the strategy of growth factors", Cell 79, 927-930.
7. Baserga, R. (1995) "The insulin-like growth factor I receptor: a key to tumor growth?", Cancer Res. 55, 249-252.
8. Braulke, T. (1999) "Type-2 IGF receptor: a multi-ligand binding protein", Horm. Metab. Res. 31, 242-246.
9. Brooks, P.C., Klemke, R.L., Schon, S., Lewis, J.M., Schwartz, M.A. and Cheresh, D.A. (1997) "Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo", J. Clin. Investig. 99, 1390-1398.
10. Brown, J., Esnouf, R.M., Jones, M.A., Linnell, J., Harlos, K., Hassan, A.B. and Jones, E.Y. (2002) "Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur", EMBO J. 21, 1054-1062.
11. Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G.N., Verma, C., Turkenburg, J.P., de Bree, F.M. and Dauter, Z. (2002) "Structural origins of the functional divergence of human insulin-like growth factor-I and insulin", Biochemistry 41, 9389-9397.
12. Chakravarti, A., Loeffler, J.S. and Dyson, N.J. (2002) "Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling", Cancer Res. 62, 200-207.
13. Ciardiello, F. and Tortora, G. (2001) "A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor", Clin. Cancer Res. 7, 2958-2970.
14. Daughaday, W.H., Trivedi, B. and Baxter, R.C. (1993) "Serum "big insulin-like growth factor II" from patients with tumor hypoglycemia lacks normal E-domain O-linked glycosylation, a possible determinant of normal propeptide processing", Proc. Natl Acad. Sci. USA 90, 5823-5827.
15. DeChiara, T.M., Efstratiadis, A. and Robertson, E.J. (1990) "A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting", Nature 345, 78-80.
16. Denley, A., Bonython, E.R., Cosgrove, L.J., Forbes, B.E., Ward, C.W.W. and Wallace, J.C. (2004) "The C and D domains of IGF-II are the major determinants of high affinity binding by the exon 11 minus isoform of the insulin receptor". Submitted for Publication.
17. Du, J., Brink, M., Peng, T., Mottironi, B. and Delafontaine, P. (2001) "Thrombin regulates insulin-like growth factor-1 receptor transcription in vascular smooth muscle: characterization of the signaling pathway", Circ. Res. 88, 1044-1052.
18. Eden, S., Constancia, M., Hashimshony, T., Dean, W., Goldstein, B., Johnson, A.C., Keshet, I., Reik, W. and Cedar, H. (2001) "An upstream repressor element plays a role in Igf2 imprinting" , EMBO J. 20, 3518-3525.
19. Firth, S.M. and Baxter, R.C. (2002) "Cellular actions of the insulin-like growth factor binding proteins", Endocr Rev. 23, 824-854.
20. Frasca, F., Pandini, G., Scalia, P., Sciacca, L., Mineo, R., Costantino, A., Goldfine, I.D., Belfiore, A. and Vigneri, R. (1999) "Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells", Mol. Cell Biol. 19, 3278-3288.
21. Garrett, T.P., McKern, N.M., Lou, M., Frenkel, M.J., Bentley, J.D., Lovrecz, G.O., Elleman, T.C., Cosgrove, L.J. and Ward, C.W. (1998) "Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor", Nature 394, 395-399.
22. Gilmore, A.P., Valentijn, A.J., Wang, P., Ranger, A.M., Bundred, N., O'Hare, M.J., Wakeling, A., Korsmeyer, S.J. and Streuli, C.H. (2002) "Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor", J. Biol. Chem. 277, 27643-27650.
23. Giuliano, M., Vento, R., Lauricella, M., Calvaruso, G., Carabillo, M. and Tesoriere, G. (1996) "Role of insulin-like growth factors in autocrine growth of human retinoblastoma Y79 cells", Eur. J. Biochem. 236, 523-532.
24. Hallak, H., Moehren, G., Tang, J., Kaou, M., Addas, M., Hoek, J.B. and Rubin, R. (2002) "Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes", Hepatology 36, 1509-1518.
25. Hermanto, U., Zong, C.S. and Wang, L.H. (2000) "Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation", Cell Growth Differ. 11, 655-664.
26. Harbin, A., Dubrez, L., Coll, J.L. and Favrot, M.C. (2002) "Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines", J. Biol. Chem. 277, 49127-49133.
27. Kahlert, S., Nuedling, S., van Eickels, M., Vetter, H., Meyer, R. and Grohe, C. (2000) "Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway", J. Biol. Chem. 275, 18447-18453.
28. Klotz, D.M., Hewitt, S.C., Ciana, P., Raviscioni, M., Lindzey, J.K., Foley, J., Maggi, A., DiAugustine, R.P. and Korach, K.S. (2002) "Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk", J. Biol. Chem. 277, 8531-8537.
29. Lassarre, C. and Ricort, J.M. (2003) "Growth factor-specific regulation of insulin receptor substrate-1 expression in MCF-7 breast carcinoma cells: effects on the insulin-like growth factor signaling pathway", Endocrinology 144, 4811-4819.
30. Lee, A.V., Jackson, J.G., Gooch, J.L., Hilsenbeck, S.G., Coronado-Heinsohn, E., Osborne, C.K. and Yee, D. (1999) " Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo", Mol. Endocrinol. 13, 787-796.
31. LeRoith, D. and Roberts, C.T. Jr., (1993) "Insulin-like growth factors", Ann. N. Y. Acad. Sci. 692, 1-9.
32. LeRoith, D., Werner, H., Beitner-Johnson, D. and Roberts, C.T., Jr. (1995) "Molecular and cellular aspects of the insulin-like growth factor I receptor", Endocr. Rev. 16, 143-163.
33. Liu, J.P., Baker, J., Perkins, A.S., Robertson, E.J. and Efstratiadis, A. (1993) "Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)", Cell 75, 59-72.
34. Louvi, A., Accili, D. and Efstratiadis, A. (1997) "Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development", Dev. Biol. 189, 33-48.
35. Lu, Y., Zi, X. and Pollak, M. (2004) "Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells", Int. J. Cancer 108, 334-341.
36. Lu, Y., Zi, X., Zhao, Y., Mascarenhas, D. and Pollak, M. (2001) "Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)", J. Natl Cancer Inst. 93, 1852-1857.
37. Luetteke, N.C., Qiu, T.H., Fenton, S.E., Troyer, K.L., Riedel, R.F., Chang, A. and Lee, D.C. (1999) "Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development", Development 126, 2739-2750.
38. Marshall, C.J. (1995) "Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation", Cell 80, 179-185.
39. Mincione, G., Esposito, D.L., Di Marcantonio, M.C., Piccirelli, A., Cama, A. and Colletta, G. (2003) "TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells", Exp. Cell Res. 287, 411-423.
40. Morelli, C., Garofalo, C., Bartucci, M. and Surmacz, E. (2003) "Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells", Oncogene 22, 4007-4016.
41. Ohlsson, C., Kley, N., Werner, H. and LeRoith, D. (1998) "p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1", Endocrinology 139, 1101-1117.
42. Putz, T., Culig, Z., Eder, I.E., Nessler-Menardi, C., Bartsch, G., Grunicke, H., Uberall, F. and Klocker, H. (1999) " Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines", Cancer Res. 59, 227-233.
43. Roudabush, F.L., Pierce, K.L., Maudsley, S., Khan, K.D. and Luttrell, L.M. (2000) "Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells", J. Biol. Chem. 275, 22583-22589.
44. Ruan, W. and Kleinberg, D.L. (1999) "Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development", Endocrinology 140, 5075-5081.
45. Sakano, K., Enjoh, T., Numata, F., Fujiwara, H., Marumoto, Y., Higashihashi, N., Sato, Y., Perdue, J.F. and Fujita-Yamaguchi, Y. (1991) "The design, expression, and characterization of human insulin-like growth factor II (IGF-II) mutants specific for either the IGF-II/cation-independent mannose 6-phosphate receptor or IGF-I receptor", J. Biol. Chem. 266, 20626-20635.
46. Schaffer, M.L., Deshayes, K., Nakamura, G., Sidhu, S. and Skelton, N.J. (2003) "Complex with a phage display-derived peptide provides insight into the function of insulin-like growth factor I", Biochemistry 42, 9324-9334.
47. Steller, M.A., Delgado, C.H. and Zou, Z. (1995) "Insulin-like growth factor II mediates epidermal growth factor-induced mitogenesis in cervical cancer cells", Proc. Natl Acad. Sci. USA 92, 11970-11974.
48. Stull, M.A., Richert, M.M., Loladze, A.V. and Wood, T.L. (2002) "Requirement for IGF-I in epidermal growth factor-mediated cell cycle progression of mammary epithelial cells", Endocrinology 143, 1972-1879.
49. Swantek, J.L. and Baserga, R. (1999) "Prolonged activation of ERK2 by epidermal growth factor and other growth factors requires a functional insulin-like growth factor 1 receptor", Endocrinology 140, 3163-3169.
50. Vajdos, F.F., Ultsch, M., Schaffer, M.L., Deshayes, K.D., Liu, J., Skelton, N.J. and de Vos, A.M. (2001) "Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions", Biochemistry 40, 11022-11029.
51. Vardy, D.A., Kari, C., Lazarus, G.S., Jensen, P.J., Zilberstein, A., Plowman, G.D. and Rodeck, U. (1995) "Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-I", J. Cell Physiol. 163, 257-265.
52. Vicentini, C., Festuccia, C., Gravina, G.L., Angelucci, A., Marronaro, A. and Bologna, M. (2003) "Prostate cancer cell proliferation is strongly reduced by the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in vitro on human cell lines and primary cultures", J. Cancer Res. Clin. Oncol. 129, 165-174.
53. Wang, D., Patil, S., Li, W., Humphrey, L.E., Brattain, M.G. and Howell, G.M. (2002) "Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells", Oncogene 21, 2785-2796.
54. Ward, C.W. and Garrett, T.P. (2001) "The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules", BMC Bioinformatics 2, 4.
55. Werner, H., Rauscher, F.J., 3rd, Sukhatme, V.P., Drummond, I.A., Roberts, C.T., Jr. and LeRoith, D. (1994) "Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site", J. Biol. Chem. 269, 12577-125782.
56. Yarden, Y. and Sliwkowski, M.X. (2001) "Untangling the ErbB signalling network", Nat. Rev. Mol. Cell Biol. 2, 127-137.
57. Zeslawski, W., Beisel, H.G., Kamionka, M., Kalus, W., Engh, R.A., Huber, R., Lang, K. and Holak, T.A. (2001) "The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5", EMBO J. 20, 3638-3644.
58. Zhang, H., Hoff, H. and Sell, C. (2000) "Insulin-like growth factor I-mediated degradation of insulin receptor substrate-1 is inhibited by epidermal growth factor in prostate epithelial cells", J. Biol. Chem. 275, 22558-22562.
59. Zhang, L., Zhan, Q., Zhan, S., Kashanchi, F., Forriace, A.J., Jr., Seth, P. and Helman, L.J. (1998) "p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells", DNA Cell Biol. 17, 125-131.