Effect of NF-κB inhibition on TNF-α-induced apoptosis in human RPE cells

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 7, 2004, Pages 2438-2446

  Yang, Ping ^a   McKay, Brian S ^a   Allen, Janice B ^b,c   Jaffe, Glenn J ^a,d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d DUKE UNIVERSITY EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLICE INHIBITORY PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROTECTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NEUROPROTECTION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VITREORETINOPATHY;

ADENOVIRIDAE; APOPTOSIS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CARRIER PROTEINS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 3; CASPASES; CELL SURVIVAL; CELLS, CULTURED; HUMANS; I-KAPPA B PROTEINS; INHIBITOR OF APOPTOSIS PROTEINS; INTERLEUKIN-1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-KAPPA B; PIGMENT EPITHELIUM OF EYE; PROTEINS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 3142653063     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0805     Document Type: Article

References (53)

1. Charteris DG. Proliferative vitreoretinopathy: pathobiology, surgical management, and adjunctive treatment. Br J Ophthalmol. 1995;79:953-960.
2. Pastor JC. Proliferative vitreoretinopathy: an overview. Surv Ophthalmol. 1998;43:3-18.
3. Kirchhof B, Sorgente N. Pathogenesis of proliferative vitreoretinopathy: modulation of retinal pigment epithelial cell functions by vitreous and macrophages. Dev Ophthalmol. 1989;16:1-53.
4. Hueber A, Aduckathil S, Kociok N, et al. Apoptosis-mediating receptor-ligand systems in human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2002;240:551-556.
5. Dunaief JL, Dentchev T, Ying GS, Milam AH. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol. 2002;120:1435-1442.
6. Reed JC. Apoptosis-based therapies. Nat Rev Drug Discov. 2002;1:111-121.
7. Armstrong D, Augustin a J, Spengler R, et al. Detection of vascular endothelial growth factor and tumor necrosis factor α in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy and macular pucker. Ophthalmologica. 1998;212:410-414.
8. Limb GA, Alam A, Earley O, et al. Distribution of cytokine proteins within epiretinal membranes in proliferative vitreoretinopathy. Curr Eye Res. 1994;13:791-798.
9. Oh H, Takagi H, Takagi C, et al. The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes. Invest Ophthalmol Vis Sci. 1999;40:1891-1898.
10. El-Ghrably IA, Dua HS, Orr GM, Fischer D, Tighe PJ. Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse transcription polymerase chain reaction. Br J Ophthalmol. 1999;83:1296-1299.
11. Limb GA, Little BC, Meager A, et al. Cytokines in proliferative vitreoretinopathy. Eye. 1991;5:686-693.
12. Chaum E. Proliferative vitreoretinopathy. Int Ophthalmol Clin. 1995;35:163-173.
13. Weller M, Heimann K, Wiedemann P. The pathogenesis of vitreoretinal proliferation and traction: a working hypothesis. Med Hypotheses. 1990;31:157-159.
14. Jin M, He S, Worpel V, Ryan SJ, Hinton DR. Promotion of adhesion and migration of RPE cells to provisional extracellular matrices by TNF-α. Invest Ophthalmol Vis Sci. 2000;41:4324-4332.
15. Burke JM. Stimulation of DNA synthesis in human and bovine RPE by peptide growth factors: the response to TNF-α and EGF is dependent upon culture density. Curr Eye Res. 1989;8:1279-1286.
16. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol. 1994;10:405-455.
17. Xiao CW, Yan X, Li Y, Reddy SA, Tsang BK. Resistance of human ovarian cancer cells to tumor necrosis factor a is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory protein. Endocrinology. 2003;144:623-630.
18. Stehlik C, De Martin R, Kumabashiri I, et al. Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis. J Exp Med. 1998;188:211-216.
19. Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998;281:1680-1683.
20. Chen C, Edelstein LC, Gelinas C. The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol. 2000;20:2687-2695.
21. Beg AA, Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science. 1996;274:782-784.
22. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM. Suppression of TNF-α-induced apoptosis by NF-κB. Science. 1996;274:787-789.
23. Shinoura N, Yamamoto N, Yoshida Y, et al. Adenovirus-mediated gene transduction of IκB or IκB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. Jpn J Cancer Res. 2000;91:41-51.
24. Hirahashi J, Takayanagi A, Hishikawa K, et al. Overexpression of truncated I kappa B alpha potentiates TNF-α-induced apoptosis in mesangial cells. Kidney Int. 2000;57:959-968.
25. Jaffe GJ, Earnest K, Fulcher S, Lui GM, Houston LL. Antitransferrin receptor immunotoxin inhibits proliferating human retinal pigment epithelial cells. Arch Ophthalmol. 1990;108:1163-1168.
26. Morgavi P, Cimoli G, Ottoboni C, et al. Sensitization of human glioblastoma T98G cells to VP16 and VM26 by human tumor necrosis factor. Anticancer Res. 1995;15:1423-1428.
27. Jobin C, Panja A, Hellerbrand C, et al. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. J Immunol. 1998;160:410-418.
28. Wang XC, Jobin C, Allen JB, Roberts WL, Jaffe GJ. Suppression of NF-κB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor. Invest Ophthalmol Vis Sci. 1999;40:477-486.
29. Yang P, Mckay BS, Allen JB, Roberts WL, Jaffe GJ. Effect of mutant on cytokine-induced activation of NF-κB in cultured human RPE cells. Invest Ophthalmol Vis Sci. 2003;44:1339-1347.
30. Watanabe M, Hitomi M, Van Der Wee K, et al. The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs. Microsc Microanal. 2002;8:375-391.
31. Stadelmann C, Lassmann H. Detection of apoptosis in tissue sections. Cell Tissue Res. 2000;301:19-31.
32. Waltzer L, Bienz M. The control of β-catenin and TCF during embryonic development and cancer. Cancer Metastasis Rev. 1999;18:231-246.
33. Karin M, Lin A. NF-κB at the crossroads of life and death. Nat Immunol. 2002;3:221-227.
34. Cottet S, Dupraz P, Hamburger F, et al. cFLIP protein prevents tumor necrosis factor-alpha-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells. Diabetes. 2002;51:1805-1814.
35. Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest. 2001;107:241-246.
36. Baichwal VR, Baeuerle PA. Activate NF-κB or die? Curr Biol. 1997;7:R94-R96.
37. Grimm S, Bauer MK, Baeuerle PA, Schulze-Osthoff K. Bcl-2 downregulates the activity of transcription factor NF-kappa B induced upon apoptosis. J Cell Biol. 1996;134:13-23.
38. Lin KI, Lee SH, Narayanan R, et al. Thiol agents and Bcl-2 identify an alpha virus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B. J Cell Biol. 1995;131:1149-1161.
39. Grilli M, Pizzi M, Memo M, Spano P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-κB activation. Science. 1996;274:1383-1385.
40. Bargou RC, Emmerich F, Krappmann D, et al. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest. 1997;100:2961-2969.
41. Otsuka G, Nagaya T, Saito K, et al. Inhibition of nuclear factor-kappaB activation confers sensitivity to tumor necrosis factor-alpha by impairment of cell cycle progression in human glioma cells. Cancer Res. 1999;59:4446-4452.
42. Kato T, Sawamura Y, Tada M, et al. p55 and p75 tumor necrosis factor receptor expression on human glioblastoma cells. Neurol Med Chir (Tokyo). 1995;35:567-574.
43. Shinoura N, Yamamoto N, Yoshida Y, et al. Adenovirus-mediated transfer of caspase-8 in combination with superrepressor of NF-κB drastically induced apoptosis in gliomas. Biochem Biophys Res Commun. 2000;271:544-552.
44. Bentires-Alj M, Hellin AC, Ameyar M, et al. Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs. Cancer Res. 1999;59:811-815.
45. Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J. NF-κB signals induce the expression of c-FLIP. Mol Cell Biol. 2001;21:5299-5305.
46. Krueger A, Baumann S, Krammer PH, Kirchhoff S. FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol. 2001;21:8247-8254.
47. Tschopp J, Irmler M, Thome M. Inhibition of fas death signals by FLIPs. Curr Opin Immunol. 1998;10:552-558.
48. Wallach D. Apoptosis: placing death under control. Nature. 1997;388:123,125-126.
49. Kreuz S, Siegmund D, Scheurich P, Wajant H. NF-κB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol Cell Biol. 2001;21:3964-3973.
50. Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 2002;3:401-410.
51. Deveraux QL, Reed JC. IAP family proteins: suppressors of apoptosis. Genes Dev. 1999;13:239-252.
52. Aota K, Azuma M, Tamatani T, et al. Stable inhibition of NF-kappa B in salivary gland cells does not enhance sensitivity to TNF-α-induced apoptosis due to upregulation of TRAF-1 expression. Exp Cell Res. 2002;276:111-119.
53. Bergmann MW, Loser P, Dietz R, Von Harsdorf R. Effect of NF-kappa B Inhibition on TNF-α-induced apoptosis and downstream pathways in cardiomyocytes. J Mol Cell Cardiol. 2001;33:1223-1232.