In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 2, 2006, Pages 647-653

  Lee, Young Joo ^a,c   Maeda, Jun ^b   Kusuhara, Hiroyuki ^a   Okauchi, Takashi ^b   Inaji, Motoki ^b   Nagai, Yuji ^b   Obayashi, Shigeru ^b   Nakao, Ryuji ^b   Suzuki, Kazutoshi ^b   Sugiyama, Yuichi ^a   Suhara, Tetsuya ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c Kyung Hee University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 11; CYCLOSPORIN; DRUG METABOLITE; GLYCOPROTEIN P; VALSPODAR; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CALCULATION; COMPARATIVE STUDY; CONTROLLED STUDY; DEVICE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG METABOLISM; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIMATE; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REACTION TIME; RHESUS MONKEY;

ANIMALS; BLOOD-BRAIN BARRIER; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOSPORINS; MACACA MULATTA; MALE; P-GLYCOPROTEIN; POSITRON-EMISSION TOMOGRAPHY; SUBSTRATE SPECIFICITY; VERAPAMIL;

EID: 31144434780     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.088328     Document Type: Article

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