Effect of PSC 833 liposomes and Intralipid on the transport of epirubicin in Caco-2 cells and rat intestines

Journal of Controlled Release

Volumn 76, Issue 1-2, 2001, Pages 1-10

  Lo, Yu li ^a   Liu, Fang i ^a   Cherng, Jong yuh ^a  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

Author keywords

Caco 2; Epirubicin; Intralipid; Liposomes; P Glycoprotein; PSC 833; Rat intestines

Indexed keywords

ANTINEOPLASTIC AGENT; CHOLESTEROL; DIPALMITOYLPHOSPHATIDYLCHOLINE; EPIRUBICIN; GLYCEROL; GLYCOPROTEIN P; INTRALIPID; LIPOSOME; PHOSPHOLIPID; SOYBEAN OIL; VALSPODAR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG FORMULATION; DRUG TRANSPORT; ILEUM; INTESTINE MUCOSA; JEJUNUM; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION;

ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CYCLOSPORINS; DRUG RESISTANCE, MULTIPLE; EPIRUBICIN; FAT EMULSIONS, INTRAVENOUS; HUMANS; LIPOSOMES; P-GLYCOPROTEIN;

EID: 0035845755     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00406-0     Document Type: Article

References (47)

1. Biochemistry of multidrug resistance mediated by the multidrug transporter
2. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues
3. Reversal of multidrug resistance
4. Cyclosporin. Formulation of dosage forms
5. PSC-833, a frontier in modulation of P-glycoprotein mediated multidrug resistance
6. Circumvention of P-glycoprotein-mediated drug resistance in human leukaemic cells by non-immunosuppressive cyclosporin D analogue, SDZ PSC 833
7. Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo
8. Changes in doxorubicin distribution and toxicity in mice pretreated with the cyclosporin analogue SDZ PSC 833
9. Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer
10. Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia
11. The use of liposomal anticancer agents to determine the roles of drug pharmacodistribution and P-glycoprotein (PGP) blockade in overcoming multidrug resistance (MDR)
12. Pharmacokinetics of two alternative dosage forms for cyclosporine: Liposomes and intralipid
13. Preparation and efficacy of cyclosporin-A liposomes for prolongation of cardiac allograft survival
14. Aggregation of unilamellar lecithin liposomes induced by cyclosporin
15. Pharmacokinetics and organ distribution of cyclosporin A incorporated in liposomes and mixed micelles
16. Epirubicin: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cancer chemotherapy
17. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
18. Phospholipids as multidrug resistance modulators of the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats
19. Active secretion and enterocytic drug metabolism barriers to drug absorption
20. Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats
21. Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers
22. A biophysical model of passive and polarized active transport processes in Caco-2 cells: Approaches to uncoupling apical and basolateral membrane events in the intact cell
23. Inhibition of intestinal P-glycoprotein and effects on etoposide absorption
24. Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. II. In situ and in vitro absorption characteristics of azetirelin from the rat intestine
25. The pharmacokinetics of high-dose epirubicin and of the cardioprotector ADR-529 given together with cyclophosphamide, 5-fluorouracil, and tamoxifen in metastatic breast-cancer patients
26. Mechanism of action of P-glycoprotein in relation to passive membrane permeation
27. In vitro transepithelial drug transport by on-line measurement: Cellular control of paracellular and transcellular transport
28. Effect of PSC 833 on the cytotoxicity of idarubicin and idarubicinol in multidrug-resistant K562 cells
29. Human hepatoma cells rich in P-glycoprotein are sensitive to aclarubicin and resistant to three other anthracyclines
30. Cyclosporin A and PSC 833 prevent up-regulation of MDR1 expression by anthracyclines in a human multidrug-resistant cell line
31. Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP
32. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
33. Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells
34. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2)
35. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells
36. Liposomal doxorubicin circumvents PSC 833-free drug interactions, resulting in effective therapy of multidrug-resistant solid tumors
37. Increased intracellular drug accumulation and complete chemosensitization achieved in multidrug-resistant solid tumors by co-administering valspodar (PSC 833) with sterically stabilized liposomal doxorubicin
38. Interactions of liposomes with mamalian cells
39. Phospholipid trafficking and membrane biogenesis
40. Enhancement of murine tumor cell sensitivity to adriamycin by presentation of the drug in phosphatidylcholine-phosphatidylserine liposomes
41. Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes
42. Reversal of multidrug resistance phenotype by surfactants: Relationship to membrane lipid fluidity
43. Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein
44. Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice
45. ATP-dependent phosphatidylcholine translocation in rat liver canalicular plasma membrane vesicles
46. Intralipid infusion abolishes ability of human serum to cholesterol-load cultured macrophages