메뉴 건너뛰기




Volumn 74, Issue 2, 2006, Pages 322-330

The orphan nuclear receptor NR4A1 regulates insulin-like 3 gene transcription in Leydig cells

Author keywords

Gene regulation; Growth factors; Leydig cells; Ovary; Testis

Indexed keywords

CELL NUCLEUS RECEPTOR; CYCLIC AMP; HORMONE; INSULIN LIKE 3; NUCLEAR RECEPTOR NUR77; UNCLASSIFIED DRUG;

EID: 31044450240     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.105.044560     Document Type: Article
Times cited : (48)

References (61)
  • 1
    • 0027365039 scopus 로고
    • Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells
    • Adham IM, Burkhardt E, Benahmed M, Engel W. Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. J Biol Chem 1993; 268:26668-26672.
    • (1993) J Biol Chem , vol.268 , pp. 26668-26672
    • Adham, I.M.1    Burkhardt, E.2    Benahmed, M.3    Engel, W.4
  • 2
    • 0029953794 scopus 로고    scopus 로고
    • Molecular cloning and expression of the relaxin-like factor from the mouse lestis
    • Pusch W, Balvers M, Ivell R. Molecular cloning and expression of the relaxin-like factor from the mouse lestis. Endocrinology 1996; 137:3009-3013.
    • (1996) Endocrinology , vol.137 , pp. 3009-3013
    • Pusch, W.1    Balvers, M.2    Ivell, R.3
  • 3
    • 1842297539 scopus 로고    scopus 로고
    • Mouse Leydig insulin-like (Ley I-L) gene: Structure and expression during testis and ovary development
    • Zimmermann S, Schottler P, Engel W, Adham IM. Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development. Mol Reprod Dev 1997; 47:30-38.
    • (1997) Mol Reprod Dev , vol.47 , pp. 30-38
    • Zimmermann, S.1    Schottler, P.2    Engel, W.3    Adham, I.M.4
  • 5
    • 0036195674 scopus 로고    scopus 로고
    • Changes in Leydig cell gene expression during development in the mouse
    • O'Shaughnessy PJ, Willerton L, Baker PJ. Changes in Leydig cell gene expression during development in the mouse. Biol Reprod 2002; 66:966-975.
    • (2002) Biol Reprod , vol.66 , pp. 966-975
    • O'Shaughnessy, P.J.1    Willerton, L.2    Baker, P.J.3
  • 6
    • 0036972315 scopus 로고    scopus 로고
    • The expression of the RLF/INSL3 gene is reduced in Leydig cells of the aging rat testis
    • Paust HJ, Wessels J, Ivell R, Mukhopadhyay AK. The expression of the RLF/INSL3 gene is reduced in Leydig cells of the aging rat testis. Exp Gerontol 2002; 37:1461-1467.
    • (2002) Exp Gerontol , vol.37 , pp. 1461-1467
    • Paust, H.J.1    Wessels, J.2    Ivell, R.3    Mukhopadhyay, A.K.4
  • 7
    • 0017655350 scopus 로고
    • Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism
    • Cattanach BM, Iddon CA, Charlton HM, Chiappa SA, Fink G. Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 1977; 269:338-340.
    • (1977) Nature , vol.269 , pp. 338-340
    • Cattanach, B.M.1    Iddon, C.A.2    Charlton, H.M.3    Chiappa, S.A.4    Fink, G.5
  • 10
    • 0022762127 scopus 로고
    • The hormonal control of testicular descent
    • Hutson JM, Donahoe PK. The hormonal control of testicular descent. Endocr Rev 1986; 7:270-283.
    • (1986) Endocr Rev , vol.7 , pp. 270-283
    • Hutson, J.M.1    Donahoe, P.K.2
  • 11
    • 0021933888 scopus 로고
    • A biphasic model for the hormonal control of testiculur descent
    • Hutson JM. A biphasic model for the hormonal control of testiculur descent. Lancet 1985; 2:419-421.
    • (1985) Lancet , vol.2 , pp. 419-421
    • Hutson, J.M.1
  • 12
    • 0032989104 scopus 로고    scopus 로고
    • Cryptorchidism in mice mutant for Insl3
    • Nef S, Parada LF. Cryptorchidism in mice mutant for Insl3. Nat Genet 1999; 22:295-299.
    • (1999) Nat Genet , vol.22 , pp. 295-299
    • Nef, S.1    Parada, L.F.2
  • 16
    • 0028204907 scopus 로고
    • Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY 1-L) and chromosomal localization of the human gene (INSL3)
    • Burkhardt E, Adham IM, Brosig B, Gastmann A, Mattei MG, Engel W. Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY 1-L) and chromosomal localization of the human gene (INSL3). Genomics 1994; 20:13-19.
    • (1994) Genomics , vol.20 , pp. 13-19
    • Burkhardt, E.1    Adham, I.M.2    Brosig, B.3    Gastmann, A.4    Mattei, M.G.5    Engel, W.6
  • 18
    • 0242267093 scopus 로고    scopus 로고
    • Isolation and expression analysis of the canine insulin-like factor 3 gene
    • Truong A, Bogatcheva NV, Schelling C, Dolf G, Agoulnik AI. Isolation and expression analysis of the canine insulin-like factor 3 gene. Biol Reprod 2003; 69:1658-1664.
    • (2003) Biol Reprod , vol.69 , pp. 1658-1664
    • Truong, A.1    Bogatcheva, N.V.2    Schelling, C.3    Dolf, G.4    Agoulnik, A.I.5
  • 19
    • 0036170532 scopus 로고    scopus 로고
    • Murine relaxin-like factor promoter: Functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1
    • Koskimies P, Levallet J, Sipila P, Huhtaniemi I, Poutanen M. Murine relaxin-like factor promoter: functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1. Endocrinology 2002; 143:909-919.
    • (2002) Endocrinology , vol.143 , pp. 909-919
    • Koskimies, P.1    Levallet, J.2    Sipila, P.3    Huhtaniemi, I.4    Poutanen, M.5
  • 20
    • 0032230347 scopus 로고    scopus 로고
    • Transcription of the Leydig insulin-like gene is mediated by steroidogenic factor-1
    • Zimmermann S, Schwarzler A, Buth S, Engel W, Adham IM. Transcription of the Leydig insulin-like gene is mediated by steroidogenic factor-1. Mol Endocrinol 1998; 12:706-713.
    • (1998) Mol Endocrinol , vol.12 , pp. 706-713
    • Zimmermann, S.1    Schwarzler, A.2    Buth, S.3    Engel, W.4    Adham, I.M.5
  • 22
    • 1942477149 scopus 로고    scopus 로고
    • SF-1 a key player in the development and differentiation of steroidogenic tissues
    • Val P, Lefrancois-Martinez AM, Veyssiere G, Martinez A. SF-1 a key player in the development and differentiation of steroidogenic tissues. Nucl Recept 2003; 1:8.
    • (2003) Nucl Recept , vol.1 , pp. 8
    • Val, P.1    Lefrancois-Martinez, A.M.2    Veyssiere, G.3    Martinez, A.4
  • 23
    • 12344335015 scopus 로고    scopus 로고
    • 4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells
    • 4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells. Endocrinology 2005; 146:861-869.
    • (2005) Endocrinology , vol.146 , pp. 861-869
    • Martin, L.J.1    Tremblay, J.J.2
  • 24
    • 0035206446 scopus 로고    scopus 로고
    • LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells
    • Song KH, Park JI, Lee MO, Soh J, Lee K, Choi HS. LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells. Endocrinology 2001; 142:5116-5123.
    • (2001) Endocrinology , vol.142 , pp. 5116-5123
    • Song, K.H.1    Park, J.I.2    Lee, M.O.3    Soh, J.4    Lee, K.5    Choi, H.S.6
  • 25
    • 0027305861 scopus 로고
    • The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction
    • Wilson TE, Fahrner TJ, Milbrandt J. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol 1993; 13:5794-5804.
    • (1993) Mol Cell Biol , vol.13 , pp. 5794-5804
    • Wilson, T.E.1    Fahrner, T.J.2    Milbrandt, J.3
  • 26
    • 1642403674 scopus 로고    scopus 로고
    • Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha
    • Hong CY, Park JH, Ahn RS, Im SY, Choi HS, Soh J, Mellon SH, Lee K. Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Mol Cell Biol 2004; 24:2593-2604.
    • (2004) Mol Cell Biol , vol.24 , pp. 2593-2604
    • Hong, C.Y.1    Park, J.H.2    Ahn, R.S.3    Im, S.Y.4    Choi, H.S.5    Soh, J.6    Mellon, S.H.7    Lee, K.8
  • 27
    • 0030961743 scopus 로고    scopus 로고
    • Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: Novel mechanisms for orphan nuclear receptor action
    • Zhang P, Mellon SH. Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: novel mechanisms for orphan nuclear receptor action. Mol Endocrinol 1997; 11:891-904.
    • (1997) Mol Endocrinol , vol.11 , pp. 891-904
    • Zhang, P.1    Mellon, S.H.2
  • 28
    • 0033305667 scopus 로고    scopus 로고
    • Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1
    • Tremblay JJ, Viger RS. Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1. Mol Endocrinol 1999; 13:1388-1401.
    • (1999) Mol Endocrinol , vol.13 , pp. 1388-1401
    • Tremblay, J.J.1    Viger, R.S.2
  • 29
    • 0035089769 scopus 로고    scopus 로고
    • GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements
    • Tremblay JJ, Viger RS. GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements. Endocrinology 2001; 142:977-986.
    • (2001) Endocrinology , vol.142 , pp. 977-986
    • Tremblay, J.J.1    Viger, R.S.2
  • 32
    • 0027210053 scopus 로고
    • Expression in transgenic mice of the large T antigen of polyomavirus induces Sertoli cell tumours and allows the establishment of differentiated cell lines
    • Paquis-Flucklinger V, Michiels JF, Vidal F, Alquier C, Pointis G, Bourdon V, Cuzin F, Rassoulzadegan M. Expression in transgenic mice of the large T antigen of polyomavirus induces Sertoli cell tumours and allows the establishment of differentiated cell lines. Oncogene 1993; 8:2087-2094.
    • (1993) Oncogene , vol.8 , pp. 2087-2094
    • Paquis-Flucklinger, V.1    Michiels, J.F.2    Vidal, F.3    Alquier, C.4    Pointis, G.5    Bourdon, V.6    Cuzin, F.7    Rassoulzadegan, M.8
  • 33
    • 0018938263 scopus 로고
    • Establishment and characterization of two distinct mouse testicular epithelial cell lines
    • Mather JP. Establishment and characterization of two distinct mouse testicular epithelial cell lines. Biol Reprod 1980; 23:243-252.
    • (1980) Biol Reprod , vol.23 , pp. 243-252
    • Mather, J.P.1
  • 35
    • 0019364734 scopus 로고
    • Characterization of several clonal lines of cultured Leydig tumor cells: Gonadotropin receptors and steroidogenic responses
    • Ascoli M. Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 1981; 108:88-95.
    • (1981) Endocrinology , vol.108 , pp. 88-95
    • Ascoli, M.1
  • 36
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 37
    • 0043171067 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation: A tool for studying histone acetylation and transcription factor binding
    • Spencer VA, Sun JM, Li L, Davie JR. Chromatin immunoprecipitation: a tool for studying histone acetylation and transcription factor binding. Methods 2003; 31:67-75.
    • (2003) Methods , vol.31 , pp. 67-75
    • Spencer, V.A.1    Sun, J.M.2    Li, L.3    Davie, J.R.4
  • 38
    • 12344329357 scopus 로고    scopus 로고
    • Profiling gene expression during the differentiation and development of the murine embryonic gonad
    • Small CL, Shima JE, Uzumcu M, Skinner MK, Griswold MD. Profiling gene expression during the differentiation and development of the murine embryonic gonad. Biol Reprod 2005; 72:492-501.
    • (2005) Biol Reprod , vol.72 , pp. 492-501
    • Small, C.L.1    Shima, J.E.2    Uzumcu, M.3    Skinner, M.K.4    Griswold, M.D.5
  • 39
    • 0034992344 scopus 로고    scopus 로고
    • Gonadotropin regulation of NGFI-B messenger ribonucleic acid expression during ovarian follicle development in the ral
    • Park JI, Park HJ, Choi HS, Lee K, Lee WK, Chun SY. Gonadotropin regulation of NGFI-B messenger ribonucleic acid expression during ovarian follicle development in the ral. Endocrinology 2001; 142:3051-3059.
    • (2001) Endocrinology , vol.142 , pp. 3051-3059
    • Park, J.I.1    Park, H.J.2    Choi, H.S.3    Lee, K.4    Lee, W.K.5    Chun, S.Y.6
  • 40
    • 0026434553 scopus 로고
    • Identification of the DNA binding site for NGFI-B by genetic selection in yeast
    • Wilson TE, Fahrner TJ, Johnston M, Milbrandt J. Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 1991; 252:1296-1300.
    • (1991) Science , vol.252 , pp. 1296-1300
    • Wilson, T.E.1    Fahrner, T.J.2    Johnston, M.3    Milbrandt, J.4
  • 41
    • 0029071860 scopus 로고
    • Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice
    • Crawford PA, Sadovsky Y, Woodson K, Lee SL, Milbrandt J. Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol Cell Biol 1995; 15:4331-4336.
    • (1995) Mol Cell Biol , vol.15 , pp. 4331-4336
    • Crawford, P.A.1    Sadovsky, Y.2    Woodson, K.3    Lee, S.L.4    Milbrandt, J.5
  • 42
    • 0030977267 scopus 로고    scopus 로고
    • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
    • Cheng LE, Chan FK, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J 1997; 16:1865-1875.
    • (1997) EMBO J , vol.16 , pp. 1865-1875
    • Cheng, L.E.1    Chan, F.K.2    Cado, D.3    Winoto, A.4
  • 44
    • 8344229906 scopus 로고    scopus 로고
    • Follicle-stimulating hormone induced changes in gene expression of murine teslis
    • Sadale-Ngatchou PI, Pouchnik DJ, Griswold MD. Follicle-stimulating hormone induced changes in gene expression of murine teslis. Mol Endocrinol 2004; 18:2805-2816.
    • (2004) Mol Endocrinol , vol.18 , pp. 2805-2816
    • Sadale-Ngatchou, P.I.1    Pouchnik, D.J.2    Griswold, M.D.3
  • 45
    • 0036217072 scopus 로고    scopus 로고
    • The futropin/choriogonadotropin receptor, a 2002 perspective
    • Ascoli M, Fanelli F, Segaloff DL. The futropin/choriogonadotropin receptor, a 2002 perspective. Endocr Rev 2002; 23:141-174.
    • (2002) Endocr Rev , vol.23 , pp. 141-174
    • Ascoli, M.1    Fanelli, F.2    Segaloff, D.L.3
  • 47
    • 0018650202 scopus 로고
    • Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities
    • Gill WB, Schumacher GF, Bibbo M, Straus FH, Schoenberg HW. Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. J Urol 1979; 122:36-39.
    • (1979) J Urol , vol.122 , pp. 36-39
    • Gill, W.B.1    Schumacher, G.F.2    Bibbo, M.3    Straus, F.H.4    Schoenberg, H.W.5
  • 48
    • 0020055365 scopus 로고
    • In utero exposure to diethylstilbestrol: Adverse effects on the reproductive tract and reproductive performance and male and female offspring
    • Stillman RJ. In utero exposure to diethylstilbestrol: adverse effects on the reproductive tract and reproductive performance and male and female offspring. Am J Obstet Gynecol 1982; 142:905-921.
    • (1982) Am J Obstet Gynecol , vol.142 , pp. 905-921
    • Stillman, R.J.1
  • 49
    • 0033782443 scopus 로고    scopus 로고
    • Elevated placental estradiol: A possible etiological factor of human cryptorchidism
    • Hadziselimovic F, Geneto R, Emmons LR. Elevated placental estradiol: a possible etiological factor of human cryptorchidism. J Urol 2000; 164:1694-1695.
    • (2000) J Urol , vol.164 , pp. 1694-1695
    • Hadziselimovic, F.1    Geneto, R.2    Emmons, L.R.3
  • 50
    • 0034524712 scopus 로고    scopus 로고
    • Hormonal control of gubernaculum development during testis descent: Gubernaculum outgrowth in vitro requires both insulin-like factor and androgen
    • Emmen JM, McLuskey A, Adham IM, Engel W, Grootegoed JA, Brinkmann AO. Hormonal control of gubernaculum development during testis descent: gubernaculum outgrowth in vitro requires both insulin-like factor and androgen. Endocrinology 2000; 141:4720-4727.
    • (2000) Endocrinology , vol.141 , pp. 4720-4727
    • Emmen, J.M.1    McLuskey, A.2    Adham, I.M.3    Engel, W.4    Grootegoed, J.A.5    Brinkmann, A.O.6
  • 51
    • 0023882581 scopus 로고
    • Role of the letal pituitary in cryplorchidism induced by exogenous maternal oestrogen during pregnancy in mice
    • Grocock CA, Charlton HM, Pike MC. Role of the letal pituitary in cryplorchidism induced by exogenous maternal oestrogen during pregnancy in mice. J Reprod Fertil 1988; 83:295-300.
    • (1988) J Reprod Fertil , vol.83 , pp. 295-300
    • Grocock, C.A.1    Charlton, H.M.2    Pike, M.C.3
  • 52
    • 0034921893 scopus 로고    scopus 로고
    • From malformations to molecular mechanisms in the male: Three decades of research on endocrine disrupters
    • McLachlan JA, Newbold RR, Burow ME, Li SF. From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters. APMIS 2001; 109:263-272.
    • (2001) APMIS , vol.109 , pp. 263-272
    • McLachlan, J.A.1    Newbold, R.R.2    Burow, M.E.3    Li, S.F.4
  • 53
    • 0034663434 scopus 로고    scopus 로고
    • A molecular basis for estrogen-induced cryptorchidism
    • Nef S, Shipman T, Parada LF. A molecular basis for estrogen-induced cryptorchidism. Dev Biol 2000; 224:354-361.
    • (2000) Dev Biol , vol.224 , pp. 354-361
    • Nef, S.1    Shipman, T.2    Parada, L.F.3
  • 54
    • 0031761935 scopus 로고    scopus 로고
    • Sexual differentiation and environmental endocrine disrupters
    • Toppari J, Skakkebaek NE. Sexual differentiation and environmental endocrine disrupters. Baillieres Clin Endocrinol Metab 1998; 12:143-156.
    • (1998) Baillieres Clin Endocrinol Metab , vol.12 , pp. 143-156
    • Toppari, J.1    Skakkebaek, N.E.2
  • 55
    • 0037772270 scopus 로고    scopus 로고
    • Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate
    • Barlow NJ, Foster PM. Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol 2003; 31:397-410.
    • (2003) Toxicol Pathol , vol.31 , pp. 397-410
    • Barlow, N.J.1    Foster, P.M.2
  • 56
    • 0343090362 scopus 로고    scopus 로고
    • Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate. PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
    • Gray LE Jr, Wolf C, Lambright C, Mann P, Price M, Cooper RL, Ostby J. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate. PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health 1999; 15:94-118.
    • (1999) Toxicol Ind Health , vol.15 , pp. 94-118
    • Gray Jr., L.E.1    Wolf, C.2    Lambright, C.3    Mann, P.4    Price, M.5    Cooper, R.L.6    Ostby, J.7
  • 57
    • 0034021024 scopus 로고    scopus 로고
    • Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-bulyl) phthalate during late gestation
    • Mylchreest E, Wallace DG, Cattley RC, Foster PM. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-bulyl) phthalate during late gestation. Toxicol Sci 2000; 55:143-151.
    • (2000) Toxicol Sci , vol.55 , pp. 143-151
    • Mylchreest, E.1    Wallace, D.G.2    Cattley, R.C.3    Foster, P.M.4
  • 58
    • 0033010382 scopus 로고    scopus 로고
    • Disruption of androgen-regulated male reproductive development by di(n-bulyl) phthalale during late gestation in rats is different from flutamide
    • Mylchreesl E, Sar M, Cattley RC, Foster PM. Disruption of androgen-regulated male reproductive development by di(n-bulyl) phthalale during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol 1999; 156:81-95.
    • (1999) Toxicol Appl Pharmacol , vol.156 , pp. 81-95
    • Mylchreesl, E.1    Sar, M.2    Cattley, R.C.3    Foster, P.M.4
  • 60
    • 0346366559 scopus 로고    scopus 로고
    • Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis
    • Wilson VS, Lambright C, Furr J, Ostby J, Wood C, Held G, Gray LE Jr., Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis. Toxicol Lett 2004; 146:207-215.
    • (2004) Toxicol Lett , vol.146 , pp. 207-215
    • Wilson, V.S.1    Lambright, C.2    Furr, J.3    Ostby, J.4    Wood, C.5    Held, G.6    Gray Jr., L.E.7
  • 61
    • 20844441799 scopus 로고    scopus 로고
    • Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis
    • Liu K, Lehmann KP, Sar M, Young SS, Gaido KW. Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis. Biol Reprod 2005; 73:180-192.
    • (2005) Biol Reprod , vol.73 , pp. 180-192
    • Liu, K.1    Lehmann, K.P.2    Sar, M.3    Young, S.S.4    Gaido, K.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.