CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins

Journal of Cell Science

Volumn 114, Issue 13, 2001, Pages 2395-2404

  Howard, T L ^a   Stauffer, D R ^a   Degnin, C R ^a   Hollenberg, S M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Biological transport; Carboxypeptidases; Endosomes; Gene silencing; Nuclear matrix; Vacuoles

Indexed keywords

BIOLOGICAL MARKER; CARBOXYPEPTIDASE; CARBOXYPEPTIDASE C; CARBOXYPEPTIDASE S; CHROMATIN MODIFYING 1P PROTEIN; CHROMATIN MODIFYING 2P PROTEIN; CHROMATIN MODIFYING 5P PROTEIN; CHROMATIN MODIFYING 6P PROTEIN; CHROMATIN MODIFYING PROTEIN 1; GENE PRODUCT; HYBRID PROTEIN; MUTANT PROTEIN; SKD 1 PROTEIN; SNF7P PROTEIN; UNCLASSIFIED DRUG; VPS 4 PROTEIN; VPS24P PROTEIN;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CELL COMPARTMENTALIZATION; CELL VACUOLE; CLASSIFICATION; CONTROLLED STUDY; ENDOSOME; EUKARYOTE; FRACTIONATION; GENE DELETION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LYSOSOME; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; YEAST;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATASES; ALKYL AND ARYL TRANSFERASES; CARBOXYPEPTIDASES; CONSERVED SEQUENCE; ENDOSOMES; HUMANS; MUTATION; NUCLEAR PROTEINS; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; REPRESSOR PROTEINS; VACUOLES; YEASTS;

ANIMALIA; EUKARYOTA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0034926390     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways
2. Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p
3. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function
4. Mammalian tumor susceptibility gene 101 (TSG101) and the Yeast Homologue, Vps23p, both function in late endosomal trafficking
5. Isolation of yeast mutants defective in protein targeting to the vacuole
6. Organelle assembly in yeast: Characterization of yeast mutants defective in vacuolar biogenesis and protein sorting
7. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking
8. Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
9. Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles
10. Vacuole biogenesis in Saccharomyces cerevisiae: Protein transport pathways to the yeast vacuole
11. I-mf, a novel myogenic repressor, interacts with members of the MyoD family
12. Endocytic trafficking of megalin/RAP complexes: Dissociation of the complexes in late endosomes
13. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
14. Cytochemical staining of multivesicular body and golgi vesicles
15. Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes
16. Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast
17. Membrane transport in the endocytic pathway
18. Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
19. Transport through the yeast endocytic pathway occurs through morphologically distinct compartments and requires an active secretory pathway and Sec18p/N-ethylmaleimide-sensitive fusion protein
20. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system
21. Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells
22. Materials and methods for detection of breast cancer
23. Intracellular sorting and processing of a yeast vacuolar hydrolase: Proteinase A propeptide contains vacuolar targeting information
24. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
25. Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis
26. Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes
27. Yeast mutants affecting possible quality control of plasma membrane proteins
28. Lysosome-endosome fusion and lysosome biogenesis
29. Endocytosis and molecular sorting
30. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif
31. Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependent
32. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body
33. Phosphoinositide signaling and the regulation of membrane trafficking in yeast
34. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae
35. Morphology of the yeast endocytic pathway
36. Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment
37. Morphological classification of the yeast vacuolar protein sorting mutants: Evidence for a prevacuolar compartment in class E vps mutants
38. Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant
39. Protein sorting in Saccharomyces cerevisiae: Isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
40. Protein sorting in yeast: Mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway
41. Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae
42. Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intacellular protein trafficking
43. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
44. CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression
45. The CLUSTALX windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
46. Signal-dependent membrane protein trafficking in the endocytic pathway
47. Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes
48. A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast
49. In vitro reconstitution of intercompartmental protein transport to the yeast vacuole
50. PCR-synthesis of marker cassettes with long flanking homology regions for gene disruptions in S. cerevisiae
51. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
52. Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities
53. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
54. The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells