Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland

Journal of Lipid Research

Volumn 46, Issue 12, 2005, Pages 2636-2648

  Chandrasekharan, Subhashini ^a   Foley, Nicholas A ^a   Jania, Leigh ^a   Clark, Patsy ^b   Audoly, Laurent P ^b   Koller, Beverly H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Cyclooxygenase 1; Cytosolic prostaglandin E2 synthase; Eicosanoid; EP2; EP4; Gene regulation; Metabolism; Microsomal prostaglandin E2 synthase 1; Mouse mammary development; Prostaglandin E 2 receptors; Prostanoid

Indexed keywords

CYCLOOXYGENASE 1; ENZYME; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN E2 SYNTHASE 1; PROSTAGLANDIN E2 SYNTHASE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BREAST DEVELOPMENT; BREAST MILK; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; LACTATION; MAMMARY GLAND; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CYCLOOXYGENASE 1; DINOPROSTONE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MAMMARY GLANDS, ANIMAL; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PREGNANCY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, PROSTAGLANDIN E;

EID: 30844454204     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M500213-JLR200     Document Type: Article

References (55)

1. Langenbach, R., C. D. Loftin, C. Lee, and H. Tiano. 1999. Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis. Ann. N. Y. Acad. Sci. 889: 52-61.
2. Loftin, C. D., H. F. Tiano, and R. Langenbach. 2002. Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2. Prostaglandins Other Lipid Mediat. 68-69: 177-185.
3. Murakami, M., Y. Nakatani, T. Tanioka, and I. Kudo. 2002. Prostaglandin E synthase. Prostaglandins Other Lipid Mediat. 68-69: 383-399.
4. Jakobsson, P. J., S. Thoren, R. Morgenstern, and B. Samuelsson. 2002. Characterization of microsomal, glutathione dependent prostaglandin E synthase. Adv. Exp. Med. Biol. 507: 287-291.
5. Thoren, S., R. Weinander, S. Saha, C. Jegerschold, P. L. Pettersson, B. Samuelsson, H. Hebert, M. Hamberg, R. Morgenstern, and P. J. Jakobsson. 2003. Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J. Biol. Chem. 278: 22199-22209.
6. Kamei, D., M. Murakami, Y. Nakatani, Y. Ishikawa, T. Ishii, and I. Kudo. 2003. Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J. Biol. Chem. 278: 19396-19405.
7. Yoshimatsu, K., D. Golijanin, P. B. Paty, R. A. Soslow, P. J. Jakobsson, R. A. DeLellis, K. Subbaramaiah, and A. J. Dannenberg. 2001. Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. Clin. Cancer Res. 7: 3971-3976.
8. 2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 275: 32783-32792.
9. Uematsu, S., M. Matsumoto, K. Takeda, and S. Akira. 2002. Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J. Immunol. 168: 5811-5816.
10. Trebino, C. E., J. L. Stock, C. P. Gibbons, B. M. Naiman, T. S. Wachtmann, J. P. Umland, K. Pandher, J. M. Lapointe, S. Saha, M. L. Roach, et al. 2003. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc. Natl. Acad. Sci. USA. 100: 9044-9049.
11. 2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J. Biol. Chem. 275: 32775-32782.
12. 2 production. J. Biol. Chem. 277: 36897-36903.
13. 2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J. Biol. Chem. 278: 37937-37947.
14. Ni, H., T. Sun, X. H. Ma, and Z. M. Yang. 2003. Expression and regulation of cytosolic prostaglandin E synthase in mouse uterus during the peri-implantation period. Biol. Reprod. 68: 744-750.
15. Ni, H., T. Sun, N. Z. Ding, X. H. Ma, and Z. M. Yang. 2002. Differential expression of microsomal prostaglandin E synthase at implantation sites and in decidual cells of mouse uterus. Biol. Reprod. 67: 351-358.
16. Parent, J., and M. A. Fortier. 2005. Expression and contribution of three different isoforms of prostaglandin E synthase in the bovine endometrium. Biol. Reprod. 73: 36-44.
17. Duffy, D. M., C. L. Seachord, and B. L. Dozier. 2005. Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle. Hum. Reprod. 20: 1485-1492.
18. Tilley, S. L., L. P. Audoly, E. H. Hicks, H. S. Kim, P. J. Flannery, T. M. Coffman, and B. H. Koller. 1999. Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor. J. Clin. Invest. 103: 1539-1545.
19. 2 synthase-1. J. Biol. Chem. 279: 24866-24872.
20. Kim, H. S., G. Lee, S. W. John, N. Maeda, and O. Smithies. 2002. Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proc. Natl. Acad. Sci. USA. 99: 4602-4607.
21. Badawi, A. F., and M. C. Archer. 1998. Effect of hormonal status on the expression of the cyclooxygenase 1 and 2 genes and prostaglandin synthesis in rat mammary glands. Prostaglandins Other Lipid Mediat. 56: 167-181.
22. Clarkson, R. W., M. T. Wayland, J. Lee, T. Freeman, and C. J. Watson. 2004. Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Res. 6: R92-R109.
23. Breyer, R. M., C. K. Bagdassarian, S. A. Myers, and M. D. Breyer. 2001. Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41: 661-690.
24. Katsuyama, M., N. Nishigaki, Y. Sugimoto, K. Morimoto, M. Negishi, S. Narumiya, and A. Ichikawa. 1995. The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and Northern blot analysis. FEBS Lett. 372: 151-156.
25. Sugimoto, Y., S. Narumiya, and A. Ichikawa. 2000. Distribution and function of prostanoid receptors: studies from knockout mice. Prog. Lipid Res. 39: 289-314.
26. Penn, R. B., R. M. Pascual, Y. M. Kim, S. J. Mundell, V. P. Krymskaya, R. A. Panettieri, Jr., and J. L. Benovic. 2001. Arrestin specificity for G protein-coupled receptors in human airway smooth muscle. J. Biol. Chem. 276: 32648-32656.
27. Sonoshita, M., K. Takaku, N. Sasaki, Y. Sugimoto, F. Ushikubi, S. Narumiya, M. Oshima, and M. M. Taketo. 2001. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc (Delta 716) knockout mice. Nat. Med. 7: 1048-1051.
28. 2, E-prostanoid 2 (EP2), and EP4 receptors. J. Biol. Chem. 278: 49954-49964.
29. Hovey, R. C., A. S. Goldhar, J. Baffi, and B. K. Vonderhaar. 2001. Transcriptional regulation of vascular endothelial growth factor expression in epithelial and stromal cells during mouse mammary gland development. Mol. Endocrinol. 15: 819-831.
30. Pepper, M. S., D. Baetens, S. J. Mandriota, C. Di Sanza, S. Oikemus, T. F. Lane, J. V. Soriano, R. Montesano, and M. L. Iruela-Arispe. 2000. Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution. Dev. Dyn. 218: 507-524.
31. Williams, C. S., M. Tsujii, J. Reese, S. K. Dey, and R. N. DuBois. 2000. Host cyclooxygenase-2 modulates carcinoma growth. J. Clin. Invest. 105: 1589-1594.
32. Majima, M., H. Amano, and I. Hayashi. 2003. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends Pharmacol. Sci. 24: 524-529.
33. Seno, H., M. Oshima, T. O. Ishikawa, H. Oshima, K. Takaku, T. Chiba, S. Narumiya, and M. M. Taketo. 2002. Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 62: 506-511.
34. Houchen, C. W., W. F. Stenson, and S. M. Cohn. 2000. Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury. Am. J. Physiol. Gastrointest. Liver Physiol. 279: G858-G865.
35. 2 in radiation injury are mediated by EP2 receptor in intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 284: G490-G498.
36. 2 in human colon cancer cells. Cancer Res. 58: 362-366.
37. Ballou, L. R., R. M. Botting, S. Goorha, J. Zhang, and J. R. Vane. 2000. Nociception in cyclooxygenase isozyme-deficient mice. Proc. Natl. Acad. Sci. USA. 97: 10272-10276.
38. 2 production and alters the gastric prostanoid profile. J. Biol. Chem. 279: 23229-23237.
39. 2. Adv. Prostaglandin Thromboxane Res. 6: 129-137.
40. 2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. J. Biol. Chem. 278: 28479-28489.
41. Yin, H., C. M. Havrilla, L. Gao, J. D. Morrow, and N. A. Porter. 2003. Mechanisms for the formation of isoprostane endoperoxides from arachidonic acid. "Dioxetane" intermediate versus beta-fragmentation of peroxyl radicals. J. Biol. Chem. 278: 16720-16725.
42. Trebino, C. E., J. D. Eskra, T. S. Wachtmann, J. R. Perez, T. J. Carty, and L. P. Audoly. 2005. Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. J. Biol. Chem. 280: 16579-16585.
43. Wang, L. H., A. Hajibeigi, X. M. Xu, D. Loose-Mitchell, and K. K. Wu. 1993. Characterization of the promoter of human prostaglandin H synthase-1 gene. Biochem. Biophys. Res. Commun. 190: 406-411.
44. Schneider, N., S. Lanz, R. Ramer, D. Schaefer, and M. Goppelt-Struebe. 2001. Up-regulation of cyclooxygenase-1 in neuroblastoma cell lines by retinoic acid and corticosteroids. J. Neurochem. 77: 416-424.
45. Tanabe, T., and N. Tohnai. 2002. Cyclooxygenase isozymes and their gene structures and expression. Prostaglandins Other Lipid Mediat. 68-69: 95-114.
46. +-dependent 15-hydroxyprostaglandin dehydrogenase gene. Biochem. Biophys. Res. Commun. 235: 582-586.
47. +-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone. Endocrinology. 141: 581-597.
48. Hovey, R. C., J. F. Trott, E. Ginsburg, A. Goldhar, M. M. Sasaki, S. J. Fountain, K. Sundararajan, and B. K. Vonderhaar. 2001. Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland. Dev. Dyn. 222: 192-205.
49. Katsuyama, M., Y. Sugimoto, K. Morimoto, K. Hasumoto, M. Fukumoto, M. Negishi, and A. Ichikawa. 1997. 'Distinct cellular localization' of the messenger ribonucleic acid for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancy. Endocrinology. 138: 344-350.
50. 2 receptor subtype EP2 gene expression in the mouse uterus coincides with differentiation of the luminal epithelium for implantation. Endocrinology. 138: 4599-4606.
51. Tsuchiya, S., S. Tanaka, Y. Sugimoto, M. Katsuyama, R. Ikegami, and A. Ichikawa. 2003. Identification and characterization of a novel progesterone receptor-binding element in the mouse prostaglandin E receptor subtype EP2 gene. Genes Cells. 8: 747-758.
52. Bedrick, A. D., J. R. Britton, S. Johnson, and O. Koldovsky. 1989. Prostaglandin stability in human milk and infant gastric fluid. Biol. Neonate. 56: 192-197.
53. 2 in human milk during the first three months postpartum. Pediatr. Res. 46: 194-199.
54. 2 accelerates enzymatic and morphological maturation of the small intestine in suckling rats. Biol. Neonate. 65: 119-125.
55. Marti, A., M. J. Moreno, and M. P. Fernandez-Otero. 1994. Effect of misoprostol on the enzyme ontogeny of the rat intestine. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. 108: 331-335.