Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor

Journal of Clinical Investigation

Volumn 103, Issue 11, 1999, Pages 1539-1545

  Tilley, Stephen L ^a   Audoly, Laurent P ^b   Hicks, Elizabeth H ^a   Kim, Hyung Suk ^a   Flannery, Patrick J ^b   Coffman, Thomas M ^b   Koller, Beverly H ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN; PROSTAGLANDIN E RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DECIDUALIZATION; FEMALE; FEMALE INFERTILITY; FERTILIZATION; MOUSE; NIDATION; NONHUMAN; OVULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRODUCTION; SYSTOLIC BLOOD PRESSURE;

EID: 0032702987     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI6579     Document Type: Article

References (37)

1. 2 formation. N. Engl. J. Med. 319:689-698.
2. Coleman, R.A. Smith, W.L., and Narumiya, S. 1994. International union of pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46:205-229.
3. Negishi, M., Sugimoto, Y., and Ichikawa, A. 1995 Molecular mechanisms of diverse actions of prostanoid receptors. Biochim. Biophys. Acta. 1259:109-120.
4. Ashby, B. 1994. Interactions among prostaglandin receptors. Receptor. 4:31-42.
5. Hayashi, S., Noda, Y., and Mori, T. 1988. Analysis of the role of prostaglandins in the fertilization process. Eur. J. Obstet. Gynecol. Reprod. Biol. 29:287-297.
6. Kennedy, T.G. 1977. Evidence for a role for prostaglandins in the initiation of blastocyst implantation in the rat. Biol. Reprod. 16:286-291.
7. Tsafriri, A., Lindner, H.R., Zor, U., and Lamprecht, S.A. 1972. Physiologic role of prostaglandins in the induction of ovulation. Prostaglandins. 2:1-10.
8. Yang, Z.-M., et al. 1997. Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes. Biol. Reprod. 56:368-379.
9. Katsuyarna, M., et al. 1997. Distinct cellular localization of the messenger ribonucleic acid for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancy. Endocrinology. 138:344-350.
10. Lim, H., et al. 1997. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell. 91:197-208.
11. Sugimoto, Y., et al. Failure ot parturition in mice lacking the prostaglandin F receptor. Science. 277:681-683.
12. Murata, T., et al. 1997. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature. 388:678-682.
13. 4 triggers remodelling of the cardiovascular system at birth. Nature. 390:78-81.
14. 2 receptor. Nature. 349:617-620.
15. 2 receptor: cDNA cloning, expression and Northern blot analysis. Biochem. Biophys. Res. Commun. 184:1197-1203.
16. 2. Am. J. Physiol. 275:F955-F961.
17. Lee, J.B., and Attallah, A.A. 1975. Renal prostaglandins. Nephron. 15:350-368.
18. Mohn, A., and Koller, B.H. 1995. Genetic manipulation of embryonic stem cells. In DNA cloning 4. D.M. Glover and B.D. Hames, editors. Oxford University Press. New York, NY. 143-184.
19. Krege, J.H., Hodgin, J.B., Hagaman, J.R., and Smithies, O. 1995. A non-invasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension. 25:1111-1115.
20. Oliver, M.I., Best, C.F.K.H.S., Arendshorst, W.J., Smithies, O., and Coffman, T.M. 1997. Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. Am. J. Physiol. 272:F515-F520.
21. 2. J. Clin. Invest. 102:1194-2001.
22. Tsafriri, A. 1995. Ovulation as a tissue remodelling process. In Tissue renin-angtotensm systems. A.K Mukhipadhyay and M.K. Raizada, editors. Plenum Press. New York, NY. 121-140.
23. Schuetz, A.W., and Dubin, N.H. 1981. Progesterone and prostaglandin secretion by ovulated rat cumulus cell-oocyte complexes. Endocrinology. 108:457-463.
24. 1 on rabbit sperm transport in vivo. J. Reprod. Fertil. 31:263-269.
25. Poulos, A., Voglmayr, J.K., and White, I.G. 1973. Phospholipid changes in spermatozoa during passage through the genital tract of the bull. Biochim. Biophys. Acta. 306:194-202.
26. Hayashi, S., Noda, Y., Matsumoto, H., and Mori, T. 1987. Fertilization of unovulated mature eggs following indomethacin administration in mice. Gamete Res. 18:291
27. Al-Bazzaz, F, Yadava, V.P., and Westenfelder, C. 1981. Modification of Na and Cl transport in canine tracheal mucosa by prostaglandins. Am. J. Physiol. 240:F101-F105.
28. Breyer, M.D., et al. 1998. Regulation of renal function by prostaglandin E receptors. Kidney Int. 54(Suppl. 67):S88-S94.
29. 2 subtype. Prostaglandins. 54:713-725.
30. 2 subtype: cloning expression and Northern blot analysis. FEBS Lett 372:151-156.
31. Lee, J.B., Covino, B.G., Takman, B.H, and Smith, E.R. 1965. Renamedullary vasodepressor substance, medullin: isolation, chemical characterization, and physiological properties. Circ. Res. 17:57-77.
32. 2 as the principal vasodepressor lipid of rabbit renal medulla. Nature. 215:1298-1299.
33. Hockel, G.M., and Cowley, A.W. 1980. Role of the renin-angiotensin system in prostaglandin E2-induced hypertension. Hypertension. 2:529-537.
34. Imanishi, M., et al. 1989. Aspirin lowers blood pressure in patients with renovascular hypertension. Hypertension. 14:461-468.
35. Hackenthal, E., Paul, M., Ganten, D., and Taugner, R. 1990. Morphology, physiology, and molecular biology of renin secretion. Physiol. Rev. 70:1067-1116.
36. Jensen, B.L., Schmid, C., and Kurtz, A. 1996. Prostaglandins stimulate renin secretion and renin mRNA in mouse renal juxtaglomerular cells. Am. J. Physiol. 271:F659-F669.
37. Tanimoto, K., et al. 1994. Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269:31334-31337.