Fire and ICE: The role of pyrin domain-containing proteins in inflammation and apoptosis

Clinical and Experimental Rheumatology

Volumn 20, Issue 4 SUPPL. 26, 2002, Pages

  Gumucio, Deborah L ^a   Diaz, A ^a   Schaner, P ^a   Richards, N ^a   Babcock, C ^a   Schaller, M ^a   Cesena, T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apaf 1 Wlike proteins; Caspase activation; Crypyrin; Hereditary fever syndromes; Innate immunity; NF B activation; Pyrin

Indexed keywords

ADAPTOR PROTEIN; GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PYRIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CARRIER PROTEIN; CIAS1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; MARENOSTRIN; PLASMA PROTEIN; PROTEIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; COLD URTICARIA; CONTROLLED STUDY; ENZYME ACTIVATION; FAMILIAL MEDITERRANEAN FEVER; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNE SYSTEM; INFLAMMATION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; WELLS SYNDROME; AUTOIMMUNE DISEASE; CHEMISTRY; GENETICS; IMMUNOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

APOPTOSIS; AUTOIMMUNE DISEASES; BLOOD PROTEINS; CARRIER PROTEINS; CYTOSKELETAL PROTEINS; FAMILIAL MEDITERRANEAN FEVER; HUMANS; INFLAMMATION; PROTEINS;

EID: 0036657283     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (70)

1. TNFRSF1A mutations and autoinflammatory syndromes
2. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever
3. A candidate gene for familial Mediterranean fever
4. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
5. Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CMS1, a gene highly expressed in polymorphonuclear cells and chondrocytes
6. The PYRIN domain: A novel motif found in apoptosis and inflammation proteins
7. The pyrin domain: A possible member of the death domain-fold family implicated in apoptosis and inflammation
8. The DAPIN family: A novel domain links apoptotic and interferon response proteins
9. PAAD - A new protein domain associated with apoptosis, cancer and autoimmune diseases
10. The PYRIN domain: A member of the death domain-fold superfamily
11. Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis
12. The domains of death: Evolution of the apoptosis machinery
13. The modular nature of apoptotic signaling proteins
14. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells
15. Caspase activation: The induced-proximity model
16. Apoptosome: The cellular engine for the activation of caspase-9
17. Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
18. The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators
19. A single mutated MEFV allele in Israeli patients suffering from familial Mediterranean fever and Behçet's disease (FMF-BD)
20. MEFV mutations in Behçet's disease
21. Inflammatory bowel disease in non-Ashkenazi Jews with familial Mediterranean fever
22. Prevalence and significance of the familial Mediterranean fever gene mutation encoding pyrin Q148
23. Episodic evolution of pyrin in primates: Human mutations recapitulate ancestral amino acid states
24. Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reducedpenetrance in the Ashkenazi Jewish population
25. Higher than expected carrier rates for familial Mediterranean fever in various Jewish ethnic groups
26. The genetic basis of autosomal dominant familial Mediterranean fever
27. Acute phase response and evolution of familial Mediterranean fever
28. PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B
29. Nods: A family of cytosolic proteins that regulate the host response to pathogens
30. The Nacht family - A new group of predicted NTPases implicated in apoptosis and MHC transcription activation
31. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappB
32. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
33. Genetics of programmed cell death in C. elegans: Past, present and future
34. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
35. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
36. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
37. Human Nod1 confers responsiveness to bacterial lipopolysaccharides
38. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
39. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways
40. NF-κB: A key role in inflammatory diseases
41. NFκB-dependent signaling pathways
42. Possible new role for NFκB in the resolution of inflammation
43. Interplay of signaling pathways in plant disease resistance
44. Genetic complexity of pathogen perception by plants: The example of Rcr3, a tomato gene required specifically by Cf-2
45. CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri
46. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
47. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
48. CARD15 mutations in Blau syndrome
49. The PYRIN CARD protein ASC is an activating adaptor for caspase-1
50. PYPAF7: A novel PYRIN-containing Apafl-like protein that regulates activation of NF-κB and caspase- 1-dependent cytokine processing
51. Altered cytokine export and apoptosis in mice deficient in interleukin-1b converting enzyme
52. Characterization of mice deficient in interleukin-1 beta converting enzyme
53. ICEBERG: A novel inhibitor of interleukin-1beta generation
54. Regulation of IL-1beta generation by Pseudo-ICE and ICE-BERG, two dominant negative caspase recruitment domain proteins
55. Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing
56. Molecular cloning and characterization of DEF-CAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins
57. A novel enhancer of the Apafl apoptosome involved in cytochrome c-dependent caspase activation and apoptosis
58. The spectrum of familial Mediterranean fever (FMF) mutations
59. Isolation, genomic organization, and expression analysis of the mouse and rat homologs of MEFV, the gene for familial Mediterranean fever
60. The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor
61. The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats
62. ATP-activated oligomerization as a mechanism for apoptosis regulation: Fold and mechanism prediction for CED-4
63. Leucine rich repeat structure
64. CARD structure
65. The structure of TolB, an essential component of the tol-dependent translocation system, and the protein-protein interaction with the translocation domain of colicin E9
66. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
67. Salt bridges destabilize a leucine zipper designed for maximized ion pairing between helices
68. Zinc finger structure
69. Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor
70. Protein fold analysis of the B30.2-like domain