Protein flexibility: Its role in structure and mechanism revealed by molecular simulations

Cellular and Molecular Life Sciences

Volumn 63, Issue 2, 2006, Pages 207-219

  Dodson, G ^a,b   Verma, C S ^c  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c BIOINFORMATICS INSTITUTE   (Singapore)

Author keywords

Atomistic simulation; Buried water; Chaperone; Flexibility; Lipase; Prion; Protein structure function mechanism

Indexed keywords

ACCURACY; COMPUTER SIMULATION; ENTHALPY; ENTROPY; MACROMOLECULE; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR PROBE; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; THERMODYNAMICS;

CALMODULIN; CHAPERONIN 10; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; HYDROPHOBICITY; LIGANDS; LIPASE; MODELS, MOLECULAR; PLIABILITY; PRIONS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 30744478915     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-005-5236-7     Document Type: Review

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