Prion and water: Tight and dynamical hydration sites have a key role in structural stability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 21, 2005, Pages 7535-7540

  De Simone, Alfonso ^a,b   Dodson, Guy G ^a,c   Verma, Chandra S ^c,d   Zagari, Adriana ^b,e,f   Fraternali, Franca ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF YORK   (United Kingdom)

^d BIOINFORMATICS INSTITUTE   (Singapore)

^e CNR   (Italy)

^f CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Molecular dynamics; Prion protein; Protein solvation; PrP Q217R mutation; Solvent entropy

Indexed keywords

AMYLOID; PRION PROTEIN;

ARTICLE; ENTROPY; FIBER; HUMAN; HYDRATION; HYDROGEN BOND; HYDROPHILICITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; X RAY;

AMYLOID; ANIMALS; COMPUTER SIMULATION; HUMANS; MODELS, MOLECULAR; MUTATION; PRIONS; SHEEP; SOLVENTS; THERMODYNAMICS; WATER;

OVIS ARIES;

EID: 19644385843     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501748102     Document Type: Article

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