메뉴 건너뛰기




Volumn 16, Issue 1, 2006, Pages 23-29

Transforming science: Cancer gene identification

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; NOTCH1 RECEPTOR; PROTEIN P19; PROTEIN PATCHED 2; TRANSCRIPTION FACTOR PITX2;

EID: 30644481105     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2005.11.001     Document Type: Review
Times cited : (13)

References (56)
  • 1
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • K.W. Kinzler, and B. Vogelstein Lessons from hereditary colorectal cancer Cell 87 1996 159 170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 2
    • 12344321466 scopus 로고    scopus 로고
    • Understanding transformation: Progress and gaps
    • J.S. Boehm, and W.C. Hahn Understanding transformation: progress and gaps Curr Opin Genet Dev 15 2005 13 17
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 13-17
    • Boehm, J.S.1    Hahn, W.C.2
  • 3
    • 1542515338 scopus 로고    scopus 로고
    • A census of human cancer genes
    • P.A. Futreal, L. Coin, M. Marshall, T. Down, T. Hubbard, R. Wooster, N. Rahman, and M.R. Stratton A census of human cancer genes Nat Rev Cancer 4 2004 177 183 The authors present a comprehensive list, based on published results, of well-validated human cancer genes. This review provides a useful current snap-shot of progress in understanding human cancer genetics and can help serve as the basis for future large-scale projects.
    • (2004) Nat Rev Cancer , vol.4 , pp. 177-183
    • Futreal, P.A.1    Coin, L.2    Marshall, M.3    Down, T.4    Hubbard, T.5    Wooster, R.6    Rahman, N.7    Stratton, M.R.8
  • 4
    • 30644462841 scopus 로고    scopus 로고
    • Targeted CML therapy: Controlling drug resistance, seeking cure
    • T. O'Hare, A.S. Corbin, and B.J. Druker Targeted CML therapy: controlling drug resistance, seeking cure Curr Opin Genet Dev 16 2006 92 99
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 92-99
    • O'Hare, T.1    Corbin, A.S.2    Druker, B.J.3
  • 5
    • 0034951384 scopus 로고    scopus 로고
    • STI571: Targeting BCR-ABL as therapy for CML
    • M.J. Mauro, and B.J. Druker STI571: targeting BCR-ABL as therapy for CML Oncologist 6 2001 233 238
    • (2001) Oncologist , vol.6 , pp. 233-238
    • Mauro, M.J.1    Druker, B.J.2
  • 6
    • 10644276290 scopus 로고    scopus 로고
    • Drosophila, the golden bug, emerges as a tool for human genetics
    • E. Bier Drosophila, the golden bug, emerges as a tool for human genetics Nat Rev Genet 6 2005 9 23
    • (2005) Nat Rev Genet , vol.6 , pp. 9-23
    • Bier, E.1
  • 8
    • 9144221618 scopus 로고    scopus 로고
    • Genomic instability and cancer: Scanning the Caenorhabditis elegans genome for tumor suppressors
    • G. van Haaften, R.H. Plasterk, and M. Tijsterman Genomic instability and cancer: scanning the Caenorhabditis elegans genome for tumor suppressors Oncogene 23 2004 8366 8375
    • (2004) Oncogene , vol.23 , pp. 8366-8375
    • Van Haaften, G.1    Plasterk, R.H.2    Tijsterman, M.3
  • 9
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • D. Stehelin, H.E. Varmus, J.M. Bishop, and P.K. Vogt DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA Nature 260 1976 170 173
    • (1976) Nature , vol.260 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.K.4
  • 10
    • 0141846926 scopus 로고    scopus 로고
    • Encapsidation and transduction of cellular genes by retroviruses
    • D. Muriaux, and A. Rein Encapsidation and transduction of cellular genes by retroviruses Front Biosci 8 2003 d135 d142
    • (2003) Front Biosci , vol.8
    • Muriaux, D.1    Rein, A.2
  • 11
    • 12344257683 scopus 로고    scopus 로고
    • DNA tumor viruses - The spies who lyse us
    • C.C. O'Shea DNA tumor viruses - the spies who lyse us Curr Opin Genet Dev 15 2005 18 26
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 18-26
    • O'Shea, C.C.1
  • 12
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40-transformed cells
    • D.P. Lane, and L.V. Crawford T antigen is bound to a host protein in SV40-transformed cells Nature 278 1979 261 263
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 13
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • D.I. Linzer, and A.J. Levine Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells Cell 17 1979 43 52
    • (1979) Cell , vol.17 , pp. 43-52
    • Linzer, D.I.1    Levine, A.J.2
  • 14
    • 0034696341 scopus 로고    scopus 로고
    • MMTV-induced mammary tumorigenesis: Gene discovery, progression to malignancy and cellular pathways
    • R. Callahan, and G.H. Smith MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways Oncogene 19 2000 992 1001
    • (2000) Oncogene , vol.19 , pp. 992-1001
    • Callahan, R.1    Smith, G.H.2
  • 15
    • 0025609571 scopus 로고
    • Tumorigenesis by slow-transforming retroviruses - An update
    • M. van Lohuizen, and A. Berns Tumorigenesis by slow-transforming retroviruses - an update Biochim Biophys Acta 1032 1990 213 235
    • (1990) Biochim Biophys Acta , vol.1032 , pp. 213-235
    • Van Lohuizen, M.1    Berns, A.2
  • 16
    • 0345863840 scopus 로고    scopus 로고
    • RTCGD: Retroviral tagged cancer gene database
    • K. Akagi, T. Suzuki, R.M. Stephens, N.A. Jenkins, and N.G. Copeland RTCGD: retroviral tagged cancer gene database Nucleic Acids Res 32 2004 D523 D527 The authors describe a useful web-accessible database, and the software used to create it, of proviral insertion sites from most of the recent large-scale retroviral mutagenesis projects designed to discover leukemia and lymphoma genes. Useful features include the ability to correlate specific common insertion sites with tumor lineage (e.g. B- versus T-cell), and to determine if specific common insertion sites are found together in the same tumor, thereby indicating possible cooperation in oncogenesis.
    • (2004) Nucleic Acids Res , vol.32
    • Akagi, K.1    Suzuki, T.2    Stephens, R.M.3    Jenkins, N.A.4    Copeland, N.G.5
  • 18
    • 27144554190 scopus 로고    scopus 로고
    • Cooperating cancer gene identification via oncogenic-retrovirus-induced insertional mutagenesis
    • Y. Du, S.E. Spence, N.A. Jenkins, and N.G. Copeland Cooperating cancer gene identification via oncogenic-retrovirus-induced insertional mutagenesis Blood 106 2005 2498 2505
    • (2005) Blood , vol.106 , pp. 2498-2505
    • Du, Y.1    Spence, S.E.2    Jenkins, N.A.3    Copeland, N.G.4
  • 21
    • 0036729878 scopus 로고    scopus 로고
    • High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
    • H. Mikkers, J. Allen, P. Knipscheer, L. Romeijn, A. Hart, E. Vink, and A. Berns High-throughput retroviral tagging to identify components of specific signaling pathways in cancer Nat Genet 32 2002 153 159
    • (2002) Nat Genet , vol.32 , pp. 153-159
    • Mikkers, H.1    Allen, J.2    Knipscheer, P.3    Romeijn, L.4    Hart, A.5    Vink, E.6    Berns, A.7
  • 23
    • 0037421961 scopus 로고    scopus 로고
    • The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma
    • P. Pajer, V. Pecenka, V. Karafiat, J. Kralova, Z. Horejsi, and M. Dvorak The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma Oncogene 22 2003 665 673
    • (2003) Oncogene , vol.22 , pp. 665-673
    • Pajer, P.1    Pecenka, V.2    Karafiat, V.3    Kralova, J.4    Horejsi, Z.5    Dvorak, M.6
  • 24
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • X. Wu, Y. Li, B. Crise, and S.M. Burgess Transcription start regions in the human genome are favored targets for MLV integration Science 300 2003 1749 1751
    • (2003) Science , vol.300 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 26
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
    • A.J. Dupuy, K. Akagi, D.A. Largaespada, N.G. Copeland, and N.A. Jenkins Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system Nature 436 2005 221 226 One of two recent studies demonstrating that a DNA-based transposon system, based on the Sleeping Beauty transposon, can be useful for forward genetic screens for cancer genes. This study shows that SB can initiate lymphoma and medulloblastoma in otherwise wild type mice. Several candidate lymphoma genes, and cancer gene interactions, are described.
    • (2005) Nature , vol.436 , pp. 221-226
    • Dupuy, A.J.1    Akagi, K.2    Largaespada, D.A.3    Copeland, N.G.4    Jenkins, N.A.5
  • 27
    • 0030662074 scopus 로고    scopus 로고
    • Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
    • Z. Ivics, P.B. Hackett, R.H. Plasterk, and Z. Izsvak Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells Cell 91 1997 501 510
    • (1997) Cell , vol.91 , pp. 501-510
    • Ivics, Z.1    Hackett, P.B.2    Plasterk, R.H.3    Izsvak, Z.4
  • 29
    • 0019973408 scopus 로고
    • T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
    • E. Santos, S.R. Tronick, S.A. Aaronson, S. Pulciani, and M. Barbacid T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes Nature 298 1982 343 347
    • (1982) Nature , vol.298 , pp. 343-347
    • Santos, E.1    Tronick, S.R.2    Aaronson, S.A.3    Pulciani, S.4    Barbacid, M.5
  • 31
    • 12144289681 scopus 로고    scopus 로고
    • A large-scale RNAi screen in human cells identifies new components of the p53 pathway
    • K. Berns, E.M. Hijmans, J. Mullenders, T.R. Brummelkamp, A. Velds, M. Heimerikx, R.M. Kerkhoven, M. Madiredjo, W. Nijkamp, and B. Weigelt A large-scale RNAi screen in human cells identifies new components of the p53 pathway Nature 428 2004 431 437 This study demonstrates the power of saturation RNAi screens to identify components of specific, cancer-relevant, signal transduction pathways in cultured mammalian cell lines.
    • (2004) Nature , vol.428 , pp. 431-437
    • Berns, K.1    Hijmans, E.M.2    Mullenders, J.3    Brummelkamp, T.R.4    Velds, A.5    Heimerikx, M.6    Kerkhoven, R.M.7    Madiredjo, M.8    Nijkamp, W.9    Weigelt, B.10
  • 32
    • 12144288006 scopus 로고    scopus 로고
    • A resource for large-scale RNA-interference-based screens in mammals
    • P.J. Paddison, J.M. Silva, D.S. Conklin, M. Schlabach, M. Li, S. Aruleba, V. Balija, A. O'Shaughnessy, L. Gnoj, and K. Scobie A resource for large-scale RNA-interference-based screens in mammals Nature 428 2004 427 431 This study demonstrates the feasibility of saturation RNAi screens in cultured mammalian cell lines using large shRNA libraries - one constructed for mouse genes and another for human genes - in a variety of expression vectors. The human shRNA library was used to identify components of the proteasome pathway as a proof-of-principle experiment.
    • (2004) Nature , vol.428 , pp. 427-431
    • Paddison, P.J.1    Silva, J.M.2    Conklin, D.S.3    Schlabach, M.4    Li, M.5    Aruleba, S.6    Balija, V.7    O'Shaughnessy, A.8    Gnoj, L.9    Scobie, K.10
  • 33
    • 20444426889 scopus 로고    scopus 로고
    • A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity
    • I.G. Kolfschoten, B. van Leeuwen, K. Berns, J. Mullenders, R.L. Beijersbergen, R. Bernards, P.M. Voorhoeve, and R. Agami A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity Cell 121 2005 849 858 This study demonstrates the use of an RNAi screen to identify components of specific, cancer-relevant, signal transduction pathways - in this case RAS signaling - to identify genes with tumor suppression activity.
    • (2005) Cell , vol.121 , pp. 849-858
    • Kolfschoten, I.G.1    Van Leeuwen, B.2    Berns, K.3    Mullenders, J.4    Beijersbergen, R.L.5    Bernards, R.6    Voorhoeve, P.M.7    Agami, R.8
  • 34
    • 20444376939 scopus 로고    scopus 로고
    • A genetic screen for candidate tumor suppressors identifies REST
    • T.F. Westbrook, E.S. Martin, M.R. Schlabach, Y. Leng, A.C. Liang, B. Feng, J.J. Zhao, T.M. Roberts, G. Mandel, and G.J. Hannon A genetic screen for candidate tumor suppressors identifies REST Cell 121 2005 837 848 This study demonstrates the use of an RNAi screen to identify genes with tumor suppression activity in human mammary epithelial cells. Candidates were then screened for mutation in human cancer, and one candidate, REST, was found to be mutated in human colorectal cancer.
    • (2005) Cell , vol.121 , pp. 837-848
    • Westbrook, T.F.1    Martin, E.S.2    Schlabach, M.R.3    Leng, Y.4    Liang, A.C.5    Feng, B.6    Zhao, J.J.7    Roberts, T.M.8    Mandel, G.9    Hannon, G.J.10
  • 36
    • 4944232647 scopus 로고    scopus 로고
    • Lung cancer: Intragenic ERBB2 kinase mutations in tumours
    • P. Stephens, C. Hunter, G. Bignell, S. Edkins, H. Davies, J. Teague, C. Stevens, S. O'Meara, R. Smith, and A. Parker Lung cancer: intragenic ERBB2 kinase mutations in tumours Nature 431 2004 525 526 This study describes a large-scale exon-re-sequencing project, focused on the ERBB2 kinase gene (also known as HER2 or NEU), in primary human lung cancer. Four percent of these tumors harbored activating mutations, demonstrating the power of this approach to identify rare subsets of patients with mutations in genes encoding proteins that could be pharmacologically targeted.
    • (2004) Nature , vol.431 , pp. 525-526
    • Stephens, P.1    Hunter, C.2    Bignell, G.3    Edkins, S.4    Davies, H.5    Teague, J.6    Stevens, C.7    O'Meara, S.8    Smith, R.9    Parker, A.10
  • 37
    • 20044381123 scopus 로고    scopus 로고
    • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
    • P. Stephens, S. Edkins, H. Davies, C. Greenman, C. Cox, C. Hunter, G. Bignell, J. Teague, R. Smith, and C. Stevens A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer Nat Genet 37 2005 590 592 This study describes a large-scale exon-re-sequencing project using human primary breast cancer specimens and cell lines. The coding exons and splice sites of the entire set of human kinases was re-sequenced. Cell lines have more changes than do primary tumor cells. Many mutations were discovered that must be very rare in breast cancer, and strong evidence for a background of non-selected variation during tumorigenesis was found. This work has implications for expected results in other similar projects, and it reports the discovery of a possible new mutator phenotype in human breast cancer.
    • (2005) Nat Genet , vol.37 , pp. 590-592
    • Stephens, P.1    Edkins, S.2    Davies, H.3    Greenman, C.4    Cox, C.5    Hunter, C.6    Bignell, G.7    Teague, J.8    Smith, R.9    Stevens, C.10
  • 41
    • 3843084078 scopus 로고    scopus 로고
    • The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
    • S. Bamford, E. Dawson, S. Forbes, J. Clements, R. Pettett, A. Dogan, A. Flanagan, J. Teague, P.A. Futreal, and M.R. Stratton The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website Br J Cancer 91 2004 355 358 The authors present a comprehensive list of all somatic mutations detected in human cancer - regardless of determination of functional significance. This catalogue is relevant for future large-scale exon-re-sequencing projects because it can provide estimates of the neutral substitution rates that might be encountered in such projects and indicates the possibility that genetic heterogeneity might be found in human cancer.
    • (2004) Br J Cancer , vol.91 , pp. 355-358
    • Bamford, S.1    Dawson, E.2    Forbes, S.3    Clements, J.4    Pettett, R.5    Dogan, A.6    Flanagan, A.7    Teague, J.8    Futreal, P.A.9    Stratton, M.R.10
  • 42
    • 0027970838 scopus 로고
    • Chromosomal translocations in human cancer
    • T.H. Rabbitts Chromosomal translocations in human cancer Nature 372 1994 143 149
    • (1994) Nature , vol.372 , pp. 143-149
    • Rabbitts, T.H.1
  • 50
    • 13144279272 scopus 로고    scopus 로고
    • Apply innovative technologies to explore cancer genome
    • I.e.M. Shih, and T.L. Wang Apply innovative technologies to explore cancer genome Curr Opin Oncol 17 2005 33 38
    • (2005) Curr Opin Oncol , vol.17 , pp. 33-38
    • Shih, E.I.M.1    Wang, T.L.2
  • 51
    • 18144418888 scopus 로고    scopus 로고
    • Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays
    • X. Zhou, N.P. Rao, S.W. Cole, S.C. Mok, Z. Chen, and D.T. Wong Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays Cancer Genet Cytogenet 159 2005 53 57
    • (2005) Cancer Genet Cytogenet , vol.159 , pp. 53-57
    • Zhou, X.1    Rao, N.P.2    Cole, S.W.3    Mok, S.C.4    Chen, Z.5    Wong, D.T.6
  • 53
    • 2542548405 scopus 로고    scopus 로고
    • DChipSNP: Significance curve and clustering of SNP-array-based loss-of-heterozygosity data
    • M. Lin, L.J. Wei, W.R. Sellers, M. Lieberfarb, W.H. Wong, and C. Li dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data Bioinformatics 20 2004 1233 1240
    • (2004) Bioinformatics , vol.20 , pp. 1233-1240
    • Lin, M.1    Wei, L.J.2    Sellers, W.R.3    Lieberfarb, M.4    Wong, W.H.5    Li, C.6
  • 54
    • 21844478747 scopus 로고    scopus 로고
    • Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    • L.A. Garraway, H.R. Widlund, M.A. Rubin, G. Getz, A.J. Berger, S. Ramaswamy, R. Beroukhim, D.A. Milner, S.R. Granter, and J. Du Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma Nature 436 2005 117 122 This study describes the analysis of NCI60 cell lines, using single nucleotide polymorphism arrays to detect loss-of-heterozygosity events and genome copy number changes. When these data were combined with expression microarray analysis, a transcription factor called MITF was found to be consistently amplified and overexpressed in a subset of human melanoma. Experiments were done to verify a role for MITF in melanoma development and maintenance. MITF is a master regulator of melanocyte specification, but on the basis of these results is also a lineage-specific oncogene.
    • (2005) Nature , vol.436 , pp. 117-122
    • Garraway, L.A.1    Widlund, H.R.2    Rubin, M.A.3    Getz, G.4    Berger, A.J.5    Ramaswamy, S.6    Beroukhim, R.7    Milner, D.A.8    Granter, S.R.9    Du, J.10
  • 55
    • 30644457228 scopus 로고    scopus 로고
    • Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults
    • G. Bignell, R. Smith, C. Hunter, P. Stephens, H. Davies, C. Greenman, J. Teague, A. Butler, S. Edkins, and C. Stevens Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults Genes Chromosomes Cancer 45 2005 42 46 The authors describe the results of re-sequencing the kinase gene family in testicular cancer. The results indicate that for some cancers somatic mutations in this family of genes are very rare.
    • (2005) Genes Chromosomes Cancer , vol.45 , pp. 42-46
    • Bignell, G.1    Smith, R.2    Hunter, C.3    Stephens, P.4    Davies, H.5    Greenman, C.6    Teague, J.7    Butler, A.8    Edkins, S.9    Stevens, C.10
  • 56
    • 24744453982 scopus 로고    scopus 로고
    • Somatic mutations of the protein kinase gene family in human lung cancer
    • H. Davies, C. Hunter, R. Smith, P. Stephens, C. Greenman, G. Bignell, J. Teague, A. Butler, S. Edkins, and C. Stevens Somatic mutations of the protein kinase gene family in human lung cancer Cancer Res 65 2005 7591 7595 The authors describe the results of re-sequencing the kinase gene family in lung cancer. The results indicate that for some lung cancers somatic mutations in this family of genes are common. However, most detected mutations are likely to be 'bystander' mutations. Although some of the mutated kinases might be driving lung cancer, each one is infrequent.
    • (2005) Cancer Res , vol.65 , pp. 7591-7595
    • Davies, H.1    Hunter, C.2    Smith, R.3    Stephens, P.4    Greenman, C.5    Bignell, G.6    Teague, J.7    Butler, A.8    Edkins, S.9    Stevens, C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.