The etiology of sepsis: Turned inside out

Trends in Molecular Medicine

Volumn 12, Issue 1, 2006, Pages 10-16

  Brunn, Gregory J ^a   Platt, Jeffrey L ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

BACTERIAL INFECTION; CANONICAL ANALYSIS; HUMAN; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; PROTEIN SECRETION; REVIEW; SEPSIS;

BACTERIA (MICROORGANISMS);

EID: 30644468833     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2005.11.002     Document Type: Article

References (84)

1. G.S. Martin The epidemiology of sepsis in the United States from 1979 through 2000 N. Engl. J. Med. 348 2003 1546 1554
2. Y. Zhai Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway J. Immunol. 173 2004 7115 7119
3. G.B. Johnson Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by toll-like receptor 4 J. Immunol. 168 2002 5233 5239
4. S. Kiechl Toll-like receptor 4 polymorphisms and atherogenesis N. Engl. J. Med. 347 2002 185 192
5. B. Beutler Sepsis begins at the interface of pathogen and host Biochem. Soc. Trans. 29 2001 853 859
6. B. Beutler Inferences, questions and possibilities in Toll-like receptor signalling Nature 430 2004 257 263
7. N.C. Riedemann The enigma of sepsis J. Clin. Invest. 112 2003 460 467
8. R.C. Bone Sepsis, the sepsis syndrome, multi-organ failure: a plea for comparable definitions Ann. Intern. Med. 114 1991 332 333
9. R.L. Paterson, and N.R. Webster Sepsis and the systemic inflammatory response syndrome J. R. Coll. Surg. Edinb. 45 2000 178 182
10. G. Majno The ancient riddle of sigma eta psi iota sigma (sepsis) J. Infect. Dis. 163 1991 937 945
11. B. Beutler, and E.T. Rietschel Innate immune sensing and its roots: the story of endotoxin Nat. Rev. Immunol. 3 2003 169 176
12. F. Magendie Remarques sur la notice precedente (de Dupre) avec quelque experiences sur les effets des substances en putrefaction J. Physiol. 3 1823 81 88
13. Panum, P.L. (1856) Didrag til Laeren om den sakaldte putride eller septiske infection. In Bibliothek for Laeger, Videnskabelig AFdeling, pp. 253-294, Experimentelle Bigrag
14. L. Pasteur Recherches sur la putrefaction C. R. Acad. Sci. 56 1863 1189 1194
15. R. Pfeiffer Untersuchungen uber das choleragift Zf.f. Hygiene 11 1892 393 412
16. O. Westphal Bacterial endotoxins. The second Carl Prausnitz Memorial Lecture Int. Arch. Allergy Appl. Immunol. 49 1975 1 43
17. D.C. Morrison Bacterial endotoxins and pathogenesis Rev. Infect. Dis. 5 Suppl 4 1983 S733 S747
18. B.M. Sultzer Endotoxin-induced resistance to a staphylococcal infection: cellular and humoral responses compared in two mouse strains J. Infect. Dis. 118 1968 340 348
19. J. Watson, and R. Riblet Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic responses to lipopolysaccharides J. Exp. Med. 140 1974 1147 1161
20. S.D. Wright Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages J. Exp. Med. 170 1989 1231 1242
21. S.D. Wright CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 249 1990 1431 1433
22. Q. Jiang Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-κB J. Immunol. 165 2000 3541 3544
23. R. Medzhitov A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 1997 394 397
24. K.V. Anderson Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product Cell 42 1985 779 789
25. F.L. Rock A family of human receptors structurally related to Drosophila Toll Proc. Natl. Acad. Sci. U. S. A. 95 1998 588 593
26. A. Poltorak Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
27. S. Akira, and K. Takeda Toll-like receptor signaling Nat. Rev. Immunol. 4 2004 499 511
28. R. Medzhitov, and C.A. Janeway Jr Decoding the patterns of self and nonself by the innate immune system Science 296 2002 298 300
29. 114 of human MD-2 are required for toll-like receptor 4-mediated activation of NF-κB by lipopolysaccharide J. Immunol. 167 2001 3354 3359
30. C. Galanos Interaction of lipopolysaccharides and lipid A with complement Eur. J. Biochem. 19 1971 143 152
31. G.B. Johnson An endogenous pathway to systemic inflammatory response syndrome (SIRS)-like responses through toll-like receptor 4 J. Immunol. 172 2004 20 24
32. A.M. Munster Translocation. Incidental phenomenon or true pathology? Ann. Surg. 218 1993 321 326
33. J.L. Kelly Is circulating endotoxin the trigger for the systemic inflammatory response syndrome seen after injury? Ann. Surg. 225 1997 530 541
34. C.P. Timmerman Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans Infect. Immun. 61 1993 4167 4172
35. J.E. Wang Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat Crit. Care Med. 32 2004 546 552
36. E. Mattsson Serum-induced potentiation of tumor necrosis factor α production by human monocytes in response to staphylococcal peptidoglycan: involvement of different serum factors Infect. Immun. 62 1994 3837 3843
37. S. Morath Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus J. Exp. Med. 193 2001 393 397
38. B.G. Yipp Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid J. Immunol. 168 2002 4650 4658
39. S.J. De Kimpe The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure Proc. Natl. Acad. Sci. U. S. A. 92 1995 10359 10363
40. J.J. Gao Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro Infect. Immun. 69 2001 751 757
41. B.M. Sultzer Genetic control of leucocyte responses to endotoxin Nature 219 1968 1253 1254
42. N.K. Surana, and J.W. St. Geme Lymphangitis after self-administration of lipopolysaccharide N. Engl. J. Med. 352 2005 944 945
43. S.M. Opal The clinical relevance of endotoxin in human sepsis: a critical analysis J. Endotoxin Res. 8 2002 473 476
44. D.L. Dunn Prevention and treatment of multiple organ dysfunction syndrome: lessons learned and future prospects Surg. Infect. (Larchmt) 1 2000 227 237
45. N.C. Riedemann Novel strategies for the treatment of sepsis Nat. Med. 9 2003 517 524
46. R.V. McCloskey Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS trial study group Ann. Intern. Med. 121 1994 1 5
47. S.N. Vogel Characterization of a congenitally LPS-resistant, athymic mouse strain J. Immunol. 122 1979 619 622
48. A.S. Cross Pretreatment with recombinant murine tumor necrosis factor α/cachectin and murine interleukin 1 α protects mice from lethal bacterial infection J. Exp. Med. 169 1989 2021 2027
49. I. Smirnova Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility Proc. Natl. Acad. Sci. U. S. A. 100 2003 6075 6080
50. I. Smirnova Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans Genetics 158 2001 1657 1664
51. E. Lorenz Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock Arch. Intern. Med. 162 2002 1028 1032
52. N.C. Arbour TLR4 mutations are associated with endotoxin hyporesponsiveness in humans Nat. Genet. 25 2000 187 191
53. S. Saadi Regional manifestations and control of the immune system FASEB J. 16 2002 849 856
54. J. Branger Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice Infect. Immun. 72 2004 788 794
55. S. Akira Toll-like receptors: critical proteins linking innate and acquired immunity Nat. Immunol. 2 2001 675 680
56. P. Matzinger An innate sense of danger Semin. Immunol. 10 1998 399 415
57. L. Alexopoulou Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 Nature 413 2001 732 738
58. F. Heil Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 Science 303 2004 1526 1529
59. S.S. Diebold Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Science 303 2004 1529 1531
60. N. Kadowaki Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens J. Exp. Med. 194 2001 863 869
61. G.B. Johnson Evolutionary clues to the functions of the Toll-like family as surveillance receptors Trends Immunol. 24 2003 19 24
62. J.L. Platt Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection J. Exp. Med. 171 1990 1363 1368
63. N.S. Key Vascular endothelial cell proteoglycans are susceptible to cleavage by neutrophils Arterioscler. Thromb. 12 1992 836 842
64. Y. Kodaira Phenotypic and functional maturation of dendritic cells modulated by heparan sulfate J. Immunol. 165 2000 1599 1604
65. L.E. Wrenshall Heparan sulfate augments the splenocyte response to mitogenic stimuli Transplant. Proc. 23 1991 325
66. C. Termeer Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4 J. Exp. Med. 195 2002 99 111
67. G.J. Brunn Conditional signaling by Toll-like receptor 4 FASEB J. 19 2005 872 874
68. M. Hirschfeld Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2 J. Immunol. 165 2000 618 622
69. M.A. Freudenberg Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin Infect. Immun. 51 1986 891 895
70. S.D. Bolmer, and J. Kleinerman Galactosamine-induced α 1-antitrypsin deficiency in rats. Alterations in plasma glycoproteins and α 1-antitrypsin carbohydrate composition Am. J. Pathol. 126 1987 209 219
71. D.C. Morrison Endotoxin-induced calcium-dependent platelet secretion: implications for generalized membrane perturbations M.K. Agarwal Bacterial Endotoxins and Host Response 1980 Elsevier North Holland Biomedical Press 311 325
72. S.B. Haudek Lipopolysaccharide dose response in baboons Shock 20 2003 431 436
73. M.M. Wurfel Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity J. Immunol. 175 2005 2570 2578
74. B. Dubois Gelatinase B deficiency protects against endotoxin shock Eur. J. Immunol. 32 2002 2163 2171
75. J. Steinberg Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats J. Surg. Res. 111 2003 185 195
76. H. Tsujimoto Neutrophil elastase, Mip-2, and Tlr-4 expression during human and experimental sepsis Shock 23 2005 39 44
77. S.P. Kishore Selective suppression of Toll-like receptor 4 activation by chemokine receptor 4 FEBS Lett. 579 2005 699 704
78. T. Netelenbos Proteoglycans on bone marrow endothelial cells bind and present SDF-1 towards hematopoietic progenitor cells Leukemia 17 2003 175 184
79. R.M. Rao Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1α and attenuates subsequent T lymphocyte transendothelial migration J. Exp. Med. 200 2004 713 724
80. S. Kakinoki The preparation of the chronic hyper-endotoxemia experimental animal model by means of a drug delivery system J. Control. Release 75 2001 167 172
81. G.B. Johnson A genetic basis for the 'Adonis' phenotype of low adiposity and strong bones FASEB J. 18 2004 1282 1284
82. G.B. Johnson Activation of mammalian toll-like receptors by endogenous agonists Crit. Rev. Immunol. 23 2003 15 44
83. J.Y. Lee Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids J. Lipid Res. 44 2003 479 486
84. L. Schaefer The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages J. Clin. Invest. 115 2005 2223 2233