Can P-glycoprotein influence the bioavailability of iminosugar-based glucosylceramide synthase inhibitors?

European Journal of Pharmacology

Volumn 530, Issue 3, 2006, Pages 195-204

  Norris Cervetto, Edward ^a,b   Butters, Terry D ^b   Martin, Catherine ^a   Modok, Szabolcs ^a   Dwek, Raymond A ^b   Callaghan, Richard ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bioavailability; Deoxygalactonojirimycin; Drug transport; Glucosylceramide synthase inhibitor; Glycolipid; P glycoprotein

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; DOXORUBICIN; FLUOROURACIL; GLYCOLIPID; GLYCOPROTEIN P; VINBLASTINE;

ARTICLE; CELL STRAIN MCF 7; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TRANSPORT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; ENZYME INHIBITORS; GLUCOSYLTRANSFERASES; GLYCOLIPIDS; HUMANS; IMINO SUGARS; P-GLYCOPROTEIN; VINBLASTINE;

EID: 30444460584     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.11.038     Document Type: Article

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