GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain

Pain

Volumn 120, Issue 1-2, 2006, Pages 170-181

  De Alba, Jorge ^a,b   Clayton, Nick M ^a   Collins, Sue D ^a   Colthup, Philip ^a   Chessell, Iain ^a   Knowles, Richard G ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Chronic inflammation; Hyperalgesia; iNOS; Neuropathic pain; Nitric Oxide

Indexed keywords

FREUND ADJUVANT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE;

ANALGESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EDEMA; HYPERSENSITIVITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NEUROPATHIC PAIN; NONHUMAN; PAIN ASSESSMENT; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPINAL CORD; SPINAL GANGLION;

ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FREUND'S ADJUVANT; HYPERALGESIA; INFLAMMATION; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; SULFIDES; TREATMENT OUTCOME;

EID: 30444458848     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2005.10.028     Document Type: Article

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