Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia

Inflammation Research

Volumn 50, Issue 2, 2001, Pages 83-88

  Guhring H ^a   Tegeder, I ^b   Lotsch J ^b   Pahl, A ^a   Werner, U ^a   Reeh, P W ^a   Rehse, K ^c   Brune, K ^a   Geisslinger, G ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

iNOS; NO donor; Paw inflammation; Spinal cord; Thermal hyperalgesia; Zymosan

Indexed keywords

NITRIC OXIDE SYNTHASE; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; FIRST PASS EFFECT; HYPERALGESIA; MEDIATOR RELEASE; MESSENGER RNA SYNTHESIS; NOCICEPTIVE STIMULATION; NONHUMAN; PAW EDEMA; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIZATION; SPINAL CORD; SPINAL CORD DORSAL HORN; THERMAL INJURY;

ANIMALS; ENZYME INHIBITORS; FOOT; HEAT; HYPERALGESIA; INFLAMMATION; KINETICS; LYSINE; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPINAL CORD; SYDNONES; ZYMOSAN;

EID: 0035093376     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050728     Document Type: Article

References (38)

1. Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw
2. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
3. Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor-kappaB activation in J774 macrophages
4. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
5. Transcriptional inhibition of the inducible nitric oxide synthase gene by competitive binding of NF-kappa B/Rel proteins
6. NF-kappa B and transcriptional control of renal epithelial-inducible nitric oxide synthase
7. The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat
8. Nitric oxide synthase and cyclo-oxygenase pathways in the inflammatory response induced by zymosan in the rat air pouch
9. Actions of isoform-selective and nonselective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon
10. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces anti-nociception in the formalin test in rats
11. Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat
12. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat
13. A nitric oxide synthesis inhibitor (L-NAME) reduces licking behavior and Foslabeling in the spinal cord of rats during formalin-induced inflammation
14. A comparison of the effects of L-NAME, 7-NI and L-NIL on carrageenan- induced hindpaw oedema and NOS activity
15. Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia
16. cGMP-dependent protein kinase in dorsal root ganglion: Relationship with nitric oxide synthase and nociceptive neurons
17. Changes in nitric oxide synthase isoforms in the spinal cord of rat following induction of chronic arthritis
18. Cytokine-mediated production of nitric oxide in isolated rat hepatocytes is dependent on cytochrome P-450III activity
19. Intraplantar zymosan as a reliable, quantifiable model of thermal and mechanical hyperalgesia in the rat
20. New no-donors with antithrombotic and vasodilating activities, X: Antiplatelet and antithrombotic effects of 3-methylsydnone-5- nitrosimine (RE 2047) in combination with ASA, pentoxifylline, and ticlopidine
21. Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXVII. Inhibition Of leucocyte adherence to endothelium by the oligoamine RE 1492C and the NO-donor RE 2047
22. Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine
23. Unilateral injection of calcitonin gene-related peptide (CGRP) induces bilateral oedema formation and release of CGRP-like immunoreactivity in the rat hindpaw
24. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
25. Measurement of free amino acids in human biological fluids by high-performance liquid chromatography
26. Systemic N-nitro-L-arginine-ester (L-NAME), inhibitor of nitric oxide synthase, relieves chronic allodynia-like symptom in rats with spinal cord lesion
27. L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2
28. L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse
29. Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation
30. The role of nitric oxide in spinal nociceptive reflexes in rats with neurogenic and non-neurogenic peripheral inflammation
31. Effects of selective inhibitors of neuronal nitric oxide synthase on carrageenan-induced mechanical and thermal hyperalgesia
32. Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw
33. Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception
34. 2+ of NMDA responses in spinal cord neurones
35. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
36. Vascular endothelial cells synthesize nitric oxide from L-arginine
37. mRNA expression of interleukins, phospholipase A2, and nitric oxide synthase in the nerve root and dorsal root ganglion induced by autologous nucleus pulposus in the rat