Allosteric activation of protein phosphatase 2C by D-chiro-inositol- galactosamine, a putative mediator mimetic of insulin action

Biochemistry

Volumn 44, Issue 33, 2005, Pages 11067-11073

  Brautigan, D L ^a   Brown, M ^b   Grindrod, S ^b   Chinigo, G ^b   Kruszewski, A ^a   Lukasik, S M ^a   Bushweller, J H ^a   Horal, M ^b   Keller, S ^b   Tamura, S ^c   Heimark, D B ^e   Price, J ^e   Larner, A N ^d   Larner, J ^e  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c TOHOKU UNIVERSITY   (Japan)

^d WESLEYAN UNIVERSITY   (United States)

^e Allomed Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BINDING ENERGY; GLUCOSE; INSULIN; OXIDATION; POLYPEPTIDES; SYNTHESIS (CHEMICAL);

ALLOSTERIC ACTIVATION; INSULIN-STIMULATED GLUCOSE; NONOXIDATIVE PATHWAY; PROTEIN PHOSPHATASE;

ENZYMES;

4 NITROPHENYL PHOSPHATE; ASPARTIC ACID; DISACCHARIDE; GALACTOSAMINE; GLUCOSE; GLYCOGEN SYNTHASE; INOSITOL DERIVATIVE; INOSITOL GALACTOSAMINE; INSULIN; INSULIN DERIVATIVE; MANGANESE; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; PINITOL BETA 1,4 GALACTOSAMINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HORMONE ACTION; HYDROGEN BOND; HYPERGLYCEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN METABOLISM; RAT; SCORING SYSTEM; SECOND MESSENGER; SIGNAL PROCESSING; SKELETAL MUSCLE; STREPTOZOCIN DIABETES; STRUCTURE ANALYSIS; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BLOOD GLUCOSE; CHELATING AGENTS; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME ACTIVATION; GALACTOSAMINE; HYDROGEN BONDING; INOSITOL; INOSITOL PHOSPHATES; INSULIN; MALE; MANGANESE; MODELS, MOLECULAR; NITROPHENOLS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHOPROTEIN PHOSPHATASE; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY;

RUMEX;

EID: 23944435412     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0508845     Document Type: Article

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