Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver

Biochemical and Molecular Medicine

Volumn 61, Issue 2, 1997, Pages 214-228

  Caro, H N ^a   Kunjara, S ^a   RadeMacHer, T W ^a   Leon Y ^b   Jones, D R ^b   Avila, M A ^b   Varela Nieto, I ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSE OXIDASE; INOSITOL; PYRUVATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHICK EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN METABOLISM; LIPOGENESIS; LIVER CELL; NONHUMAN; RAT;

ANIMALIA; BACILLUS THURINGIENSIS; BOVINAE; GALLUS GALLUS; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0031214164     PISSN: 10773150     EISSN: None     Source Type: Journal    
DOI: 10.1006/bmme.1997.2607     Document Type: Article

References (60)

1. Rosen O M. After insulin binds. Science. 237:1987;1452-1458.
2. White M F, Kahn C R. The insulin signaling system. J Biol Chem. 269:1994;1-4.
3. Lienhard G E. Life without the IRS. Nature. 372:1994;128-129.
4. Sun X J, Wang L M, Zhang Y, Yenush L, Myers M G Jr, Glasheen E, Lane W S, Pierce J H, White M F. Role of IRS-2 in insulin and cytokine signalling. Nature. 377:1995;173-177.
5. Denton R M, Tavaré J M. Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against. Eur J Biochem. 227:1995;597-611.
6. Thomas J R, Dwek R A, Rademacher T W. Structure, biosynthesis and function of glycosylphosphatidylinositols. Biochemistry. 29:1990;5413-5422.
7. Gaulton G N, Pratt J C. Glycosylated phosphatidylinositol molecules as second messengers. Semin Immunol. 6:1994;97-104.
8. Varela-Nieto I, León Y, Caro H N. Cell signalling by inositol phosphoglycans from different species. Comp Biochem Physiol. 115B:1996;223-241.
9. Lazar D F, Knez J J, Medof M E, Cuatrecasas P, Saltiel A R. Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol. Proc Natl Acad Sci USA. 91:1994;9665-9669.
10. Saltiel A R, Cuatrecasas P. Insulin stimulates the generation from hepatic membranes of modulators derived from an inositol glycolipid. Proc Natl Acad Sci USA. 83:1986;5793-5797.
11. Mato J M, Kelly K L, Abler A, Jarett L. Identification of a novel insulin-sensitive glycophospholipid from H35 hepatoma cells. J Biol Chem. 262:1987;2131-2137.
12. Larner J, Huang L C, Schwartz C F, Oswald A S, Shen T Y, Kinter M, Tang G Z, Zeller K. Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphate contains galactosamine andD-chiro. Biochem Biophys Res Commun. 151:1988;1416-1426.
13. Rademacher T W, Caro H N, Kunjara S, Wang D Y, Greenbaum A L, McLean P. Inositolphosphoglycan second messengers. Braz J Med Biol Res. 27:1994;327-341.
14. Kunjara S, Caro H N, McLean P, Rademacher T W. Tissue specific release of inositolphosphoglycans. Biopolymers and Bioproducts: Structure, Function and Applications. 1995;Dokya, Bangkok. p. 301-306.
15. Romero G, Larner J. Insulin mediators and the mechanism of insulin action. Advances in Pharmacol. 24:1993;21-50.
16. Saltiel A R, Doble A, Jacobs S, Cuatrecasas P. Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity. Biochem Biophys Res Commun. 110:1983;789-795.
17. Villalba M, Kelly K L, Mato J M. Inhibition of cyclic AMP-dependent proten kinase by the polar head group of an insulin-sensitive glycophospholipid. Biochim Biophys Acta. 968:1988;69-76.
18. Malehoff C D, Huang L, Gillespie N, Villar-Palasi C, Schwartz C FW, Cheng K, Hewlett F L, Larner J. A putative mediator of insulin action which inhibits adenylate cyclase and adenosine-3,5-monophosphate dependent protein kinase: partial purification from rat liver site and kinetic mechanism of action. Endocrinology. 120:1984;1327-1337.
19. Saltiel A R. Insulin generates an enzyme modulator from hepatic plasma membrane: regulation of cAMP phosphodiesterase, pyruvate dehydrogenase and adenylate cyclase. Endocrinology. 120:1987;967-972.
20. Saltiel A R, Fox J A, Sherline P, Cuatrecasas P. Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. Science. 233:1986;967-972.
21. Lilley K, Zhang C, Villar-Palasi C, Larner J, Huang L. Insulin mediator stimulation of pyruvate dehydrogenase phosphatases. Arch Biochem Biophys. 296:1992;170-174.
22. Larner J, Roach P J, Huang L C, Brooker G, Murad F, Hazen R. Hormonal control of glycogen metabolism. Adv Exp Med Biol. 111:1979;103-112.
23. Huang L C, Fonteles M C, Houston D B, Zhang C, Larner J. Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo. Endocrinology. 132:1993;652-657.
24. Sato T, Villar Palasi C, Huang L, Tang G, Larner A C, Larner J. Insulin and a putative insulin metabolic mediator fraction from liver and muscle stimulate p33 mRNA accumulation by apparently different mechanisms. Endocrinology. 123:1988;1559-1564.
25. Alvarez L, Avila M A, Mato J M, Castaño J G, Varela-Nieto I. Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes. Mol Endocrinol. 5:1991;1062-1068.
26. Clemente R, Jones D, Ochoa P, Romero G, Mato J M, Varela-Nieto I. Role of glycosyl-phosphatidylinositol hydrolysis as a mitogenic signal for epidermal growth factor. Cell Signalling. 7:1995;411-421.
27. Varela-Nieto I, Represa J, Avila M A, Miner C, Mato J M, Giraldez F. Inositol phospho-oligosaccharide stimulates cell proliferation in the early developing inner ear. Dev Biol. 143:1991;432-435.
28. Romero G, Gamez G, Huang L C, Lilley K, Luttrell L. Anti-inositolglycan antibodies selectively block some of the actions of insulin in intact BC3H1 cells. Proc Natl Acad Sci USA. 87:1990;1476-1480.
29. Nestler J E, Romero G, Huang L C, Zhang C G, Larner J. Insulin mediators are the signal transduction system responsible for insulin's actions on human placental steroidogenesis. Endocrinology. 129:1991;2951-2956.
30. Varela-Nieto I, Alvarez L, Mato J M. de Pablo F, Scanes C, Weintraub B D. In Handbook of Endocrine Research Techniques: Intracellular Mediators of Peptide Hormone Action: Glycosylphosphatidylinositol/Inositol Phosphoglycan System. 1993;391-406 Academic Press, San Diego.
31. Bartlett G R. Phosphorous assay in column chromatography. J Biol Chem. 234:1958;466-468.
32. Alvarez J F, Sánchez-Arias J A, Guadaño A, Estévez F, Varela I, Felíu J E, Mato J M. Transport in isolated rat hepatocytes of the phospho-oligosaccharide that mimics insulin action. Biochem J. 274:1991;369-374.
33. Avila M A, Clemente R, Varela-Nieto I. A phosphatidylinositol-linkage-deficient T-cell mutant contains insulin-sensitive glycosyl-phosphatidylinositol. Biochem J. 282:1992;681-686.
34. Gaulton G N. Differential regulation of glycosylated phosphatidylinositol subtypes by insulin. Diabetes. 40:1991;1297-1304.
35. Guther M L, de Almeida M L, Yoshida N, Ferguson M A. Structural studies on the glycosylphosphatidylinositol membrane anchor ofTrypanosoma cruzi. J Biol Chem. 239:1992;375-380.
36. Rodbell M. Metabolism of isolated fat cells. J Biol Chem. 239:1964;375-380.
37. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanadinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
38. Wahl G M, Stern M, Stark G. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxy-methyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci USA. 76:1979;3683-3687.
39. Warren Y H, Monahan J E, Short J, Short M, Bruzel A, Wynshaw-Boris A, Meisner H M, Samolds D, Hanson R W. Isolation and characterization of the gene encoding for cytosolic phosphoenolpyruvate carboxylase (GTP) from the rat. Proc Natl Acad Sci USA. 80:1983;3656-3660.
40. Velu T J, Beguinot L, Vass W C, Willingham M C, Merlino G T, Pastan I, Lowry D R. Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene. Science. 238:1987;1408-1410.
41. León Y, Vazquez E, Sanz C, Vega J A, Mato J M, Giraldez F, Represa J, Varela-Nieto I. Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression. Endocrinology. 136:1995;3494-3503.
42. Morris J C, Sheng P L, Shen T-Y, Mensa-Wilmot K. Glycan requirements of glycosylphosphatidylinositol phospholipase C fromTrypanosoma brucei. J Biol Chem. 270:1995;2517-2524.
43. Merida I, Corrales F J, Clemente R, Ruiz-Albusac J M, Villalba M, Mato J M. Different phosphorylated forms of an insulin-sensitive glycosyl-phosphatidylinositol from rat hepatocytes. FEBS Lett. 236:1988;251-255.
44. Macaulay S L, Larkins R G. Impaired insulin action in adipocytes of New Zealand obese mice: A role for postbinding defects in pyruvate dehydrogenase and insulin mediator activity. Metabolism. 37:1988;958-965.
45. Mukasa R, Umeda M, Endo T, Kobata A, Inoue K. Characterization of glycosylphosphatidylinositol (GPI)-anchored NCAM on mouse skeletal muscle cell line C2C12: The structure of the GPI glycan and release during myogenesis. Arch Biochem Biophys. 318:1995;182-190.
46. Galasko G T, Bao Y, Broomfield S J, Hooper N M, Turner A J, Larner J. Circulating factors and insulin resistance. I. A novel myoinositol 1,2-cyclic phosphate phosphoglycan insulin antagonist from human plasma is elevated in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 80:1995;2419-2429.
47. Macaulay S L, Clark S, Larkins R G. Correlation of insulin receptor level with both insulin action and breakdown of a potential insulin mediator precursor; studies in CHO cell-lines transfected with insulin receptor cDNA. Biochim Biophys Acta. 1134:1992;53-60.
48. Represa J, Avila M A, Miner C, Giraldez F, Romero G, Clemente R, Mato J, Varela-Nieto I. Glycosyl-phosphatidylinositol/inositol phosphoglycan: A signaling system for the low-affinity nerve growth factor receptor. Proc Natl Acad Sci USA. 88:1991;8016-8019.
49. Villalba M, Alvarez J F, Russell D S, Mato J M, Rosen O M. Hydrolysis of glycosyl-phosphatidylinositol in response to insulin is reduced in cells bearing kinase-deficient insulin receptors. Growth Factors. 2:1990;91-97.
50. Farese R V, Standaert M L, Yamada K, Huang L C, Zhang C, Cooper D R, Wang Z, Yang Y, Suzuki S, Toyota T, Larner J. Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. Proc Natl Acad Sci USA. 91:1994;11040-11044.
51. Macaulay S L, Larkins R G. Isolation of insulin-sensitive phosphatidylinositol-glycan from rat adipocytes. Its impaired breakdown in the streptozotocin-diabetic rat. Biochem J. 271:1990;427-435.
52. Sánchez-Arias J A, Sánchez-Gutierrez J C, Guadaño A, Alvarez J F, Samper B, Mato J M, Feliú J E. Impairment of glycosyl-phosphatidylinositol-dependent insulin signaling system in isolated rat hepatocytes by streptozotocin-induced diabetes. Endocrinology. 131:1992;1727-1733.
53. Sánchez-Gutierrez J C, Sánchez-Arias J A, Valle J C, Guadaño A, Samper B, Mato J M, Feliú J E. Insulin resistance in genetically obese (fa/fa. Endocrinology. 134:1994;1485-1492.
54. Ortmeyer H K, Bodkin N L, Lilley K, Larner J, Hansen B C. Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys. Endocrinology. 132:1993;640-645.
55. Ortmeyer H K, Huang L C, Zhang L, Hansen B C, Larner J. Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys. Endocrinology. 132:1993;646-651.
56. Fonteles M C, Huang L C, Larner J. Infusion of pH 2.0 D-chiro. Diabetologia. 39:1996;731-734.
57. Kennington A S, Hill C R, Craig J, Bogardus C, Raz I, Ortmeyer H K, Hansen B C, Romero G, Larner J. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. N Engl J Med. 323:1990;373-378.
58. Suzuki S, Kawasaki H, Satoh Y, Ohtomo M, Hirai M, Hirai A, Hirai S, Onoda M, Matsumoto M, Hinokio Y. Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes. Diabetes Care. 17:1994;1465-1468.
59. Ostlund R E Jr, McGill J B, Herskowitz I, Kipnis D M, Santiago J V, Sherman W R. D-chiro-inositol metabolism in diabetes mellitus. Proc Natl Acad Sci USA. 90:1993;9988-9992.
60. Katz E B, Stenbit A E, Hatton K, DePinho R, Charron M J. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature. 377:1995;151-155.