Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies

Virchows Archiv

Volumn 444, Issue 6, 2004, Pages 509-517

  Dreher, Tina ^a   Zentgraf, Hanswalter ^c   Abel, Ulrich ^b   Kappeler, Alexandra ^a   Michel, Maurice S ^a   Bleyl, Uwe ^a   Grobholz, Rainer ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Tumorzentrum Heidelberg/Mannheim   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Immunohistochemistry; Needle biopsy; p27kip1; Prostatic carcinoma; PTEN MMAC1

Indexed keywords

CYCLIN E; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P27; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PHOSPHATASE; PTEN PROTEIN, HUMAN; TUMOR MARKER; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ACCURACY; ADULT; AGED; ARTICLE; CANCER GRADING; CELL GROWTH; CHROMOSOME 10; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEEDLE BIOPSY; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATECTOMY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REDUCTION; TUMOR SUPPRESSOR GENE; ADENOCARCINOMA; CELL NUCLEUS; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; PROSTATE TUMOR; WESTERN BLOTTING;

ADENOCARCINOMA; AGED; BIOPSY, NEEDLE; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROSTATECTOMY; PROSTATIC NEOPLASMS; PTEN PHOSPHOHYDROLASE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 3042849062     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-004-1004-6     Document Type: Article

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