Design of peptide analogues with improved activity using a novel de novo protein design approach

Industrial and Engineering Chemistry Research

Volumn 43, Issue 14, 2004, Pages 3817-3826

  Klepeis, J L ^a   Floudas, Christodoulos A ^a   Morikis, D ^b   Tsokos, C G ^c   Lambris, J D ^c  

^a Princeton University   (United States)

^b University of California ^*  (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; INTEGER PROGRAMMING; PROBABILITY DISTRIBUTIONS; PROBLEM SOLVING; PROTEINS;

FOLD STABILITY; INTEGER LINEAR PROGRAMMING; PROTEIN DESIGNS;

POLYPEPTIDES;

COMPLEMENT COMPONENT C3; COMPSTATIN; CYCLOPEPTIDE; PEPTIDE DERIVATIVE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ENZYME; PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CALCULATION; COMPLEMENT ACTIVATION; COMPUTER AIDED DESIGN; COMPUTER PROGRAM; INTEGER LINEAR PROGRAM; PROBABILITY; PROTEIN DESIGN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

EID: 3042785531     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie0340995     Document Type: Article

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