Total Synthesis of Epothilone A: The Macrolactonization Approach

Angewandte Chemie (International Edition in English)

Volumn 36, Issue 5, 1997, Pages 525-527

  Nicolaou, K C ^a,b   Sarabia, Francisco ^a,b   Ninkovic, Sacha ^a,b   Yang, Zhen ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antitumor agents; Epothilones; Macrolactonization; Natural products; Total synthesis

Indexed keywords

EID: 0030980104     PISSN: 05700833     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.199705251     Document Type: Article

References (19)

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14. For the first total synthesis of 1, see e) A. Balog, D. Meng, T. Kamenecka, P. Bertinato, D.-S. Su, E. J. Sorensen, S. J. Danishefsky, Angew. Chem. 1996, 108, 2801-2803; Angew. Chem. Int. Ed. Engl. 1996, 35, 2976-2978.
15. For the first total synthesis of 1, see e) A. Balog, D. Meng, T. Kamenecka, P. Bertinato, D.-S. Su, E. J. Sorensen, S. J. Danishefsky, Angew. Chem. 1996, 108, 2801-2803; Angew. Chem. Int. Ed. Engl. 1996, 35, 2976-2978.
16. For an olefin metathesis-based total synthesis of 1, see f) Z. Yang, Y. He, D. Vourloumis, H. Vallberg, K. C. Nicolaou, Angew. Chem. 1997, 109, 170-172; Angew. Chem. Int. Ed. Engl. 1997, 36, 166-168. Editorial note: see also another description of the total synthesis of 1 in this issue: D. Schinzer, A. Limburg, A. Bauer, O. M. Böhm, M. Cordes, Angew. Chem. 1997, 109, 543-544; Angew. Chem. Int. Ed. Engl. 1997, 36, 523-524.
17. For an olefin metathesis-based total synthesis of 1, see f) Z. Yang, Y. He, D. Vourloumis, H. Vallberg, K. C. Nicolaou, Angew. Chem. 1997, 109, 170-172; Angew. Chem. Int. Ed. Engl. 1997, 36, 166-168. Editorial note: see also another description of the total synthesis of 1 in this issue: D. Schinzer, A. Limburg, A. Bauer, O. M. Böhm, M. Cordes, Angew. Chem. 1997, 109, 543-544; Angew. Chem. Int. Ed. Engl. 1997, 36, 523-524.
18. For an olefin metathesis-based total synthesis of 1, see f) Z. Yang, Y. He, D. Vourloumis, H. Vallberg, K. C. Nicolaou, Angew. Chem. 1997, 109, 170-172; Angew. Chem. Int. Ed. Engl. 1997, 36, 166-168. Editorial note: see also another description of the total synthesis of 1 in this issue: D. Schinzer, A. Limburg, A. Bauer, O. M. Böhm, M. Cordes, Angew. Chem. 1997, 109, 543-544; Angew. Chem. Int. Ed. Engl. 1997, 36, 523-524.
19. For an olefin metathesis-based total synthesis of 1, see f) Z. Yang, Y. He, D. Vourloumis, H. Vallberg, K. C. Nicolaou, Angew. Chem. 1997, 109, 170-172; Angew. Chem. Int. Ed. Engl. 1997, 36, 166-168. Editorial note: see also another description of the total synthesis of 1 in this issue: D. Schinzer, A. Limburg, A. Bauer, O. M. Böhm, M. Cordes, Angew. Chem. 1997, 109, 543-544; Angew. Chem. Int. Ed. Engl. 1997, 36, 523-524.