Rational design, synthesis, and reactivity of lactendiynes, a new class of cyclic enediynes ortho-fused with the β-lactam ring

Tetrahedron

Volumn 53, Issue 9, 1997, Pages 3249-3268

  Banfi, Luca ^a   Basso, Andrea ^a   Guanti, Giuseppe ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AZETIDINE DERIVATIVE; MACROCYCLIC COMPOUND;

ARTICLE; CALCULATION; CYCLIZATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0031550881     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)00036-7     Document Type: Article

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56. 31. It is worth noting that, while 14 (note 18) tended to polymerize in the dry state, 46 proved to be more stable and was recovered intact after several days in freezer.
57. 3OD alone, the peaks were badly resolved.
58. 33. These compounds failed to elute in GC at temperatures up to 280°C, because of their too low volatility. or of their low thermal stability.