Structural analysis of cDNA encoding thymidylate synthase in hepatic metastases of human colorectal tumors

International Journal of Colorectal Disease

Volumn 16, Issue 5, 2001, Pages 318-325

  Yousef, A M ^a   Davis, R A ^a   Sticca, R P ^a   Berger, S H ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Colon tumor metastases; DNA polymorphism; Thymidylate synthase gene expression; Thymidylate synthase gene structure; Thymidylate synthase immunoassay

Indexed keywords

COMPLEMENTARY DNA; FLUOROURACIL; MESSENGER RNA; NUCLEOTIDE; THYMIDYLATE SYNTHASE;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CANCER ADJUVANT THERAPY; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION FUNCTION; DNA DETERMINATION; DNA STRUCTURE; DRUG TARGETING; GENE AMPLIFICATION; GENE ISOLATION; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; LIVER METASTASIS; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

COLORECTAL NEOPLASMS; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIVER NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; THYMIDYLATE SYNTHASE; UP-REGULATION;

EID: 0034805118     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003840100319     Document Type: Article

References (35)

1. Lessons from hereditary colorectal cancer
2. New antimetabolites in cancer chemotherapy and their clinical impact
3. The catalytic mechanism and structure of thymidylate synthase
4. Thymine metabolism and thymineless death in prokaryotes and eucaryotes
5. Thymidylate synthase: A target for combination therapy and determinant of chemotherapeutic response in colorectal cancer
6. Structural and functional analysis of the human thymidylate synthase gene
7. Identification of functional elements in the promoter region of the human gene for thymidylate synthase and nuclear factors that regulate the expression of the gene
8. Transcriptional control elements and complex initiation pattern of the TATA-less bidirectional human thymidylate synthase promoter
9. Splicing signals are required for S-phase regulation of the mouse thymidylate synthase gene
10. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase
11. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase
12. Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations
13. Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal tumors
14. Identification of an RNA binding site for human thymidylate synthase
15. Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA
16. A comprehensive review of 5-fluorouracil and leucovorin in patients with metastatic colorectal cancer
17. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
18. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
19. Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy
20. Thymidylate synthase as a determinant of 5-fluoro-2′-deoxyuridine response in human colon tumor cell lines
21. Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase
22. A structural role for glutamine 214 in human thymidylate synthase
23. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction
24. Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line
25. Mitomycin C resistance in a human colon carcinoma cell line associated with cell surface protein alterations
26. Regional assignment of the human thymidylate synthase (TS) gene to chromosome band 18p11.32 by nonisotopic in situ hybridization
27. Nucleotide sequence of a functional cDNA for human thymidylate synthase
28. Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine
29. Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma
30. Consistent deficiencies of chromosome 18 and of the short arm of chromosome 17 in eleven cases of human large bowel cancer: A possible recessive determinism
31. Identification of a chromosome 18q gene that is altered in colorectal cancers
32. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
33. Alternate splicing of the rTS gene product and its overexpression in a 5-fluorouracil-resistant cell line
34. Role in translation of a triple tandemly repeated sequence in the 5′-untranslated region of human thymidylate synthase mRNA