Interferon γ enhances both in vitro and in vivo priming of CD4 + T cells for IL-4 production

Journal of Experimental Medicine

Volumn 199, Issue 12, 2004, Pages 1619-1630

  Bocek Jr , Petr ^a   Foucras, Gilles ^a,b   Paul, William E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Cell differentiation; Cytokine; T cell activation; T lymphocyte subsets; T bet

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 4 ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD28; MONOCLONAL ANTIBODY CD3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; KNOCKOUT MOUSE; LEISHMANIA MAJOR; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; TH2 CELLS; TRANSCRIPTION FACTORS;

EID: 3042592465     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20032014     Document Type: Article

References (36)

1. Rao, A., and O. Avni. 2000. Molecular aspects of T-cell differentiation. Br. Med. Bull. 56:969-984.
2. Murphy, K.M., W. Ouyang, J.D. Farrar, J. Yang, S. Ranganath, H. Asnagli, M. Afkarian, and T.L. Murphy. 2000. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18:451-494.
3. Seder, R.A., and W.E. Paul. 1994. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12:635-673.
4. Kaplan, M.H., Y.L. Sun, T. Hoey, and M.J. Grusby. 1996. Impaired IL12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 382:174-177.
5. Shimoda, K., J. van Deursen, M.Y. Sangster, S.R. Sarawar, R.T. Carson, R.A. Tripp, C. Chu, F.W. Quelle, T. Nosaka, D.A. Vignali, P.C. Doherty, G. Grosveld, W.E. Paul, and J.N. Ihle. 1996. Lack of IL4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 380:630-633.
6. Szabo, S.J., S.T. Kim, G.L. Costa, X. Zhang, C.G. Fathman, and L.H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 100:655-669.
7. Zheng, W., and R.A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 89:587-596.
8. Szabo, S.J., A.S. Dighe, U. Gubler, and K.M. Murphy. 1997. Regulation of the interleukin (IL)-12R β 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
9. Zhang, Y., R. Apilado, J. Coleman, S. Ben-Sasson, S. Tsang, J. Hu-Li, W.E. Paul, and H. Huang. 2001. Interferon γ stabilizes the T helper cell type 1 phenotype. J. Exp. Med. 194:165-172.
10. Bradley, L.M., D.K. Dalton, and M. Croft. 1996. A direct role for IFN-gamma in regulation of Th1 cell development. J. Immunol. 157:1350-1358.
11. Wenner, C.A., M.L. Guler, S.E. Macatonia, A. O'Garra, and K.M. Murphy. 1996. Roles of IFN-gamma and IFN-alpha in IL12-induced T helper cell-1 development. J. Immunol. 156: 1442-1447.
12. Lighvani, A.A., D.M. Frucht, D. Jankovic, H. Yamane, J. Aliberti, B.D. Hissong, B.V. Nguyen, M. Gadina, A. Sher, W.E. Paul, and J.J. O'Shea. 2001. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA. 98:15137-15142.
13. Usui, T., R. Nishikomori, A. Kitani, and W. Strober. 2003. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL12Rbeta2 chain or T-bet. Immunity 18:415-428.
14. Wang, Z.E., S. Zheng, D.B. Corry, D.K. Dalton, R.A. Seder, S.L. Reiner, and Reiner, and R.M. Locksley. 1994. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc. Natl. Acad. Sci. USA. 91:12932-12936.
15. Belosevic, M., D.S. Finbloom, P.H. Van Der Meide, M.V. Slayter, and C.A. Nacy. 1989. Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266-274.
16. + effector cells default to the Th2 pathway in interferon γ-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367-1371.
17. + T cell response. J. Exp. Med. 181:961-971.
18. Eriksson, U., M.O. Kurrer, W. Sebald, F. Brombacher, and M. Kopf. 2001. Dual role of the IL12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL12 and protection by IFN-gamma. J. Immunol. 167:5464-5469.
19. Wensky, A., M.C. Marcondes, and J.J. Lafaille. 2001. The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunity. J. Immunol 167:3074-3081.
20. Dalton, D.K., S. Pitts-Meek, S. Keshav, I.S. Figari, A. Bradley, and T.A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 259:1739-1742.
21. Guery, J.C., F. Galbiati, S. Smiroldo, and L. Adorini. 1996. Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and β(2)-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485-497.
22. Kearney, E.R., T.L. Walunas, R.W. Karr, P.A. Morton, D.Y. Loh, J.A. Bluestone, and M.K. Jenkins. 1995. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155:1032-1036.
23. Noben-Trauth, N., P. Kropf, and I. Muller. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science. 271:987-990.
24. Erb, K.J., B. Ruger, M. von Brevern, B. Ryffel, A. Schimpl, and K. Rivett. 1997. Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice. J. Exp. Med. 185:329-339.
25. + T helper type 1 cell responses to Candida albicans. J. Exp. Med. 187:307-317.
26. Schuler, T., Z. Qin, S. Ibe, N. Noben-Trauth, and T. Blankenstein. 1999. T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice. J. Exp. Med. 189:803-810.
27. Bagley, J., T. Sawada, Y. Wu, and J. Iacomini. 2000. A critical role for interleukin 4 in activating alloreactive CD4 T cells. Nat. Immunol. 1:257-261.
28. Huang, L.R., F.L. Chen, Y.T. Chen, Y.M. Lin, and J.T. Kung. 2000. Potent induction of long-term CD8+ T cell memory by short-term IL4 exposure during T cell receptor stimulation. Proc. Natl. Acad. Sci. USA. 97:3406-3411.
29. Hochrein, H., M. O'Keeffe, T. Luft, S. Vandenabeele, RJ. Grumont, E. Maraskovsky, and K. Shortman. 2000. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL12 production by mouse and human dendritic cells. J. Exp. Med. 192:823-833.
30. Biedermann, T., S. Zimmermann, H. Himmelrich, A. Gumy, O. Egeter, A.K. Sakrauski, I. Seegmuller, H. Voigt, P. Launois, A.D. Levine, et al. 2001. IL4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat. Immunol. 2:1054-1060.
31. Brogdon, J.L., D. Leitenberg, and K. Bottomly. 2002. The potency of TCR signaling differentially regulates NFATc/p activity and early IL4 transcription in naive CD4+ T cells. J. Immunol. 168:3825-3832.
32. Noben-Trauth, N., J. Hu-Li, and W.E. Paul. 2002. IL4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation. Eur. J. Immunol. 32:1428-1433.
33. Eisenbarth, S.C., D.A. Piggott, J.W. Huleatt, I. Visintin, C.A. Herrick, and K. Bottomly. 2002. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196:1645-1651.
34. So, E.Y., H.H. Park, and C.E. Lee. 2000. IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL4-induced IL4 receptor gene expression. J. Immunol. 165:5472-5479.
35. Gajewski, T.F., and F.W. Fitch. 1988. Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140:4245-4252.
36. Refaeli, Y., L. Van Pirijs, S.I. Alexander, and A.K. Abbas. 2002. Interferon γ is required for activation-induced death of T lymphocytes. J. Exp. Med. 196:999-1005.