Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells

European Journal of Biochemistry

Volumn 271, Issue 12, 2004, Pages 2417-2427

  Moore, Elizabeth H ^a   Napolitano, Mariarosaria ^b   Avella, Michael ^a   Bejta, Fatos ^a   Suckling, Keith E ^c   Bravo, Elena ^b   Botham, Kathleen M ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antioxidants; Chylomicron remnants; Lipid accumulation; Macrophages; Probucol

Indexed keywords

1,1' DIOCTADECYL 3,3,3',3' TETRAMETHYLINDO CARBOCYANINE PERCHLORATE; ANTIOXIDANT; CARBOCYANINE; CHOLESTEROL; CHOLESTEROL ESTER; CHYLOMICRON; FLUORESCENT DYE; LIPID; MESSENGER RNA; OLEIC ACID; PHOSPHOLIPID; PROBUCOL; TRIACYLGLYCEROL; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INCUBATION TIME; LIPID STORAGE; LIPID TRANSPORT; MACROPHAGE; MONOCYTE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIOXIDANTS; CARBOCYANINES; CAROTENOIDS; CELL LINE; CHYLOMICRON REMNANTS; CHYLOMICRONS; COPPER SULFATE; FLUORESCENT DYES; HUMANS; LIPID METABOLISM; MACROPHAGES; OXIDATION-REDUCTION; PROBUCOL; RNA, MESSENGER;

TRITIUM;

EID: 3042518879     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04164.x     Document Type: Article

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