Vitamin E supplementation of human macrophages prevents neither foam cell formation nor increased susceptibility of foam cells to lysis by oxidized LDL

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 9, 2000, Pages 2078-2086

  Asmis, Reto ^a,b   Jelk, Jennifer ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Cell death; Foam cells; Macrophages; Oxidized LDL; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; ATHEROSCLEROSIS; CELL DEATH; CELL GROWTH; CELL MATURATION; CELL PROTECTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOLYSIS; FOAM CELL; HUMAN; HUMAN CELL; LIPID COMPOSITION; MACROPHAGE; MALE; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 0033818767     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.9.2078     Document Type: Article

References (56)

1. Prevention of early stages of cardiovascular disease and cancer may require concurrent optimization of all major antioxidants and other nutrients: An update and reevaluation of observational data and intervention trials
2. Vitamin E consumption and the risk of coronary disease in women
3. Vitamin E consumption and the risk of coronary heart disease in men
4. Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
5. Antioxidants and atherosclerosis: A current assessment
6. On the antioxidant hypothesis with regard to arteriosclerosis
7. Vitamin E and other essential antioxidants regarding coronary heart disease: Risk assessment study: Epidemiological basis of the anti-oxidant hypothesis of cardiovascular disease
8. Ten-year retrospective on the antioxidant hypothesis of arteriosclerosis: Threshold plasma levels of antioxidant micronutrients related to minimum cardiovascular risk
9. Conner Memorial Lecture: Oxidative modification of LDL and atherogenesis
10. Oxidized low-density lipoprotein, a two-faced Janus in coronary artery disease?
11. Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis
12. Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein
13. LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial ceils in culture
14. Oxidized low-density lipoprotein is cytotoxic to human monocyte-macrophages: Protection with lipophilic antioxidants
15. The effect of α-tocopherol supplementation on LDL oxidation: A dose-response study
16. The role of lipid Peroxidation and antioxidants in oxidative modification of LDL
17. Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation
18. Effects of supplements with vitamin E on the uptake of low density lipoprotein and the stimulation of cholesteryl ester formation in macrophages
19. Prevention of cholesteryl ester accumulation in P388D1 macrophage-like cells by increased cellular vitamin E depends on species of extracellular cholesterol: Conventional heterologous non-human cell cultures are poor models of human atherosclerotic foam cell formation
20. Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages
21. Influence of native and modified lipoproteins on migration of mouse peritoneal macrophages and the effect of the antioxidants vitamin E and probucol
22. Uptake and degradation of low density lipoproteins in atherosclerotic rabbit aorta: Role of local LDL modification
23. Relation of vascular oxidative stress, α-tocopherol, and hypercholesterolemia to early atherosclerosis in hamsters
24. Effects of tocopherol deficiency on lipid metabolism in the arterial wall of rats on normal and high cholesterol diets
25. Antiatherosclerotic effects of antioxidants are lesion-specific when evaluated in hypercholesterolemic New Zealand White rabbits
26. Plasma LDL oxidation leads to its aggregation in the atherosclerotic apolipoprotein E-deficient mice
27. Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouse
28. Large variations in human foam cell formation in individuals: A fully autologous in vitro assay biased on the quantitative analysis of cellular neutral lipids
29. Differential expression of CD14, CD36 and the LDL receptor on human monocyte-derived macrophages: A novel cell culture system to study macrophage differentiation and heterogeneity
30. Enhanced macrophage uptake of low density lipoprotein after self-aggregation
31. 1 macrophage-like cells
32. Concurrent quantification of cellular cholesterol, cholesteryl esters and triglycerides in small biological samples
33. A rapid method of total lipid extraction and purification
34. Assay for nanogram quantities of DNA in cellular homogenates
35. Toxicity of oxidized low density lipoprotein towards mouse peritoneal macrophages in vitro
36. Dehydroascorbic acid prevents apoptosis induced by oxidized low density lipoprotein in human monocyte-derived macrophages
37. Vitamin E: Function and metabolism
38. Lack of correlation between the alpha-tocopherol content of plasma and LDL, but high correlations for gamma-tocopherol and carotenoids
39. Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene
40. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
41. Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: An epidemiological update with special attention to carotene and vitamin C
42. Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer
43. Regulation of serum-induced lipid accumulation in human monocyte-derived macrophages by interferon-gamma: Correlations with apolipoprotein E production, lipoprotein lipase activity and LDL receptor-related protein expression
44. The response-to-retention hypothesis of early atherogenesis
45. The response-to-retention hypothesis of atherogenesis reinforced
46. Do vitamin E supplements in diets for laboratory animals jeopardize findings in animal models of disease?
47. Dietary antioxidants do not reduce fatty streak formation in the C57BL/6 mouse atherosclerosis model
48. Lipoproteins, lipoprotein oxidation, and atherogenesis
49. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis
50. Vitamin E and vascular homeostasis: Implications for atherosclerosis
51. Macrophages and atherosclerotic plaque stability
52. Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study
53. Vitamin E levels in human atherosclerotic plaque: The influence of risk factors
54. Depletion of alpha-tocopherol in human atherosclerotic lesions
55. Lipids and oxidised lipids in human atheroma and normal aorta
56. Low density lipoprotein oxidation and its pathobiological significance