Chylomicron remnant induction of lipid accumulation in J774 macrophages is associated with up-regulation of triacylglycerol synthesis which is not dependent on oxidation of the particles

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1631, Issue 3, 2003, Pages 255-264

  Napolitano, Mariarosaria ^a   Avella, Michael ^b   Botham, Kathleen M ^b   Bravo, Elena ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Cholesterol esterification; Chylomicron remnant; Macrophage; Polyunsaturated fatty acid; Triacylglycerol

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTERASE; CHYLOMICRON; COPPER SULFATE; CORN OIL; GLYCEROL; TRIACYLGLYCEROL;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; IN VIVO STUDY; INCUBATION TIME; LIPID COMPOSITION; LIPID STORAGE; MACROPHAGE; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SYNTHESIS; UPREGULATION;

MURINAE; ZEA MAYS;

EID: 0037426322     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(03)00042-8     Document Type: Article

References (47)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
2. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 272:1997;20963-20966.
3. Napolitano M., Rivabene R., Avella M., Botham K.M., Bravo E. The internal redox balance of cells influences the metabolism of lipids of dietary origin by J774 macrophages: implications for foam cell formation. J. Vasc. Res. 38:2001;350-360.
4. Batt K.V., Botham K.M., Jackson B., Suckling K.E. Comparison of the effects of low density lipoprotein and chylomicron remnants on foam cell formation in the human monocytic cell line, THP-1. Atheroscler. Suppl. 2:2001;109.
5. Yu K.C., Mamo J.C.L. Chylomicron remnant-induced foam cell formation and cytotoxicity: a possible mechanism of cell death in atherosclerosis. Clin. Sci. (Lond.). 298:2000;183-192.
6. Redgrave T.G. Formation and metabolism of chylomicrons. Int. Rev. Physiol. 28:1983;103-130.
7. Mamo J.C.L. Atherosclerosis as a post-prandial disease. Endocrinol. Metab. 2:1995;229-244.
8. Benlian P., De Gennes P.L., Foubert L., Zhang H., Gagne S.E., Hayden M. Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene. N. Engl. J. Med. 335:1996;848-854.
9. Groot P.H.E., van Stiphout W.A.H., Krauss X.H., Jansen H., van Tol A., van Ramshorst E., Chin-On S., Hofmann A., Cresswell S.R., Havekes L. Postprandial lipoprotein metabolism in normolipidemic men with and without coronary heart disease. Arterioscler. Thromb. 11:1991;653-662.
10. Yla-Herttuala S., Jaakkola O., Enholm C., Tikkanen M.J., Solakivi T., Sarkioja T., Nikkari T. Characterisation of two lipoproteins containing apolipoproteins B and E from lesion-free human aortic intima. J. Lipid Res. 29:1988;563-572.
11. Proctor S.D., Mamo J.C.L. Retention of fluorescent-labelled chylomicron remnants within the intima of the artery wall - evidence that plaque cholesterol may be derived from post-prandial lipoproteins. Eur. J. Clin. Investig. 28:1998;497-503.
12. Grieve D.J., Avella M., Elliott J., Botham K.M. Influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta. Atherosclerosis. 139:1998;273-281.
13. Mamo J.C.L., Wheeler J.R. Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low density lipoprotein, high density lipoprotein and albumin. Coron. Artery Dis. 5:1994;695-705.
14. Gianturco S.H., Brown S.A., Via D.P., Bradley W.A. The β-VLDL receptor pathway of murine P388D1 macrophages. J. Lipid Res. 27:1986;412-420.
15. Bersot T.P., Innerarity T.L., Pitas R.E., Rall R.C., Weisgraber K.H., Mahley R.W. Fat feeding in humans induces lipoproteins of density less than 1.006 that are rich in apolipoprotein (a) and that cause foam cell formation in macrophages. J. Clin. Invest. 77:1986;622-630.
16. Koo C., Wernett-Hammond M.E., Garcia Z., Malloy M.J., Uauy R., East C., Bilheimer D., Mahley R.W., Innerarity T.L. Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors. J. Clin. Invest. 81:1988;1332-1340.
17. Ellsworth J.L., Fong F.B., Kraemer F.B., Cooper A.D. Differences in the processing of chylomicron remnants and β-VLDL by macrophages. J. Lipid Res. 31:1990;1399-1411.
18. Mamo J.C.L., Ellsgood C.L., Yu K., Schumann S., Redgrave T.G. Chylomicron remnants metabolism by macrophages. Atherosclerosis. 109:1994;107.
19. Elsegood C.L., Pal S., Roach P.D., Mamo J.C.L. Binding and uptake of chylomicron remnants by primary and THP-1 monocyte-derived macrophages: determination of binding proteins. Clin. Sci. (Lond.). 101:2001;111-119.
20. Ellsworth J.L., Kraemer F.B., Cooper A.D. Transport of β-very low density lipoproteins and chylomicron remnants by macrophages is mediated by the low density lipoprotein receptor pathway. J. Biol. Chem. 262:1987;2316-2325.
21. Truswell A.S. Reducing the risk of coronary heart disease. Br. Med. J. 291:1985;34-37.
22. Harris W.S. Dietary fish oils and blood lipids. Curr. Opin. Lipidol. 7:1996;3-7.
23. Thornberg J.T., Rudel L.L. How do polyunsaturated fatty acids lower lipids? Curr. Opin. Lipidol. 3:1992;17-21.
24. Lambert M.S., Botham K.M., Mayes P.A. Modification of the composition of dietary oils and fats upon incorporation into chylomicron remnants. Br. J. Nutr. 76:1996;435-445.
25. Lambert M.S., Botham K.M., Mayes P.A. Variations in composition of dietary fats affect hepatic uptake and metabolism of chylomicron remnants. Biochem. J. 310:1995;845-852.
26. Lambert M.S., Avella M.A., Berhane Y., Shervill E., Botham K.M. The fatty acid composition of chylomicron remnants influences their binding and internalisation by isolated hepatocytes. Eur. J. Biochem. 268:2001;3983-3992.
27. Zheng X., Avella M., Botham K.M. Comparison of the effects of dietary n-3 and n-6 polyunsaturated fatty acids on very low density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants. Biochem. J. 357:2001;481-487.
28. Clarke S.D., Jump D.B. Dietary polyunsaturated fatty acid regulation of gene transcription. Annu. Rev. Nutr. 14:1994;83-98.
29. Brown M.S., Goldstein J.L. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Ann. Rev. Biochem. 52:1983;223-261.
30. Cases S., Smith S.J., Zheng Y.W., Myers H.M., Lear S.R., Sande E., Novak S., Collins C., Welch C.B., Lusis A.J., Erickson S.K., Farese R.V. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. U. S. A. 95:1998;13018-13023.
31. Grieve D.J., Avella M.A., Elliott J., Botham K.M. Influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta. Atherosclerosis. 139:1998;273-281.
32. Davis R.A., Engelhorn S.C., Pangburn S.H., Weinstein D.B., Steinberg D. Very low density lipoprotein synthesis and secretion by cultured rat hepatocytes. J. Biol. Chem. 254:1979;2010-2016.
33. Brown M.S., Faust J.R., Goldstein J.L. Induction of 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. J. Biol. Chem. 253:1978;1121-1128.
34. Martinez M.J., Botham K.M. Neutral cholesteryl ester hydrolase in the rat lactating mammary gland: regulation by phosphorylation-dephosphorylation. Biochim. Biophys. Acta. 104:1990;90-98.
35. Suckling K.E., Boyd G.S., Smellie C.G. Properties of a solubilised and reconstituted preparation of acyl-CoA:cholesterol acyl transferase from rat liver. Biochim. Biophys. Acta. 710:1982;154-163.
36. Bradford M. A sensitive method of quantification of microgram quantities of protein utilizing the principle of dye-binding. Anal. Biochem. 72:1976;248-252.
37. Botham K.M., Maldonado E.N., Chico Y., Zheng X., Avella M., Ochoa B. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Biochim. Biophys. Acta. 1534:2001;96-109.
38. Esterbauer H., Shaur R.J., Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic. Biol. Med. 11:1991;81-128.
39. Joyce C., Skinner K., Anderson R.A., Rudel L.L. Acyl-coenzyme A: cholesterol acyltransferase 2. Curr. Opin. Lipidol. 10:1999;89-95.
40. Miller M. Current perspectives on the management of hypertriglyceridemia. Am. Heart J. 140:2000;232-240.
41. Bates S.R., Murphy P.L., Feng Z.C., Kanazawa T., Getz G.S. Very low density lipoproteins promote triglyceride accumulation in macrophages. Arteriosclerosis. 4:1984;103-114.
42. Ellsworth J.L., Cooper A.D., Kraemer F.B. Evidence that chylomicron remnants and β-VLDL are transported by the same receptor pathway in J774 murine macrophage-derived cells. J. Lipid Res. 27:1986;1062-1072.
43. Yu K.C., Mamo J.C.L. Regulation of cholesterol synthesis and esterification in primary cultures of macrophages following uptake of chylomicron remnants. Biochem. Mol. Biol. Int. 41:1997;33-39.
44. Ponec M., Kempenaar J.A., Havekes L., Van der Schroeff J.G., Emeis J.J., Vermeer B.J. Effects of LDL, HDL and their combination on the endogenous cholesterol synthesis in monocyte macrophages. Biochim. Biophys. Acta. 666:1981;405-410.
45. Davis P.J. n-3 and n-6 Polyunsaturated fatty acids have different effects on acyl-CoA: cholesterol acyltransferase in J774 macrophages. Biochem. Cell. Biol. 70:1992;1313-1318.
46. Jessup W., Kritharides L. Metabolism of oxidized LDL by macrophages. Curr. Opin. Lipidol. 11:2000;473-481.
47. Kinsella J.E., Lokesh B., Stone R.A. Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms. Am. J. Clin. Nutr. 52:1991;1-28.