Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall - Evidence that plaque cholesterol may be derived from post-prandial lipoproteins

European Journal of Clinical Investigation

Volumn 28, Issue 6, 1998, Pages 497-503

  Proctor, S D ^a   Mamo, J C L ^a,b,c  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b Box X 2213 GPO   (Australia)

^c Medical Research Foundation Building ^*  (Australia)

Author keywords

Arterial retention; Chylomicron remnants; Confocal microscopy; Fluorescent labelling; Post prandial lipoproteins

Indexed keywords

APOLIPOPROTEIN B100; CHOLESTEROL; CHYLOMICRON; FLUORESCENT DYE; INTERMEDIATE DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; RHODAMINE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; NONHUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; RABBIT;

ANIMALS; ARTERIES; ARTERIOSCLEROSIS; CHOLESTEROL; CHYLOMICRONS; FLUORESCENCE; LIPOPROTEINS; MICROSCOPY, CONFOCAL; RABBITS; TUNICA INTIMA;

EID: 0031814147     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1998.00317.x     Document Type: Article

References (26)

1. Albrink MJ, Man EB. Serum triglycerides in coronary artery disease. Arch Int Med 1959; 103: 4-8.
2. Keys A. Dietary lipids and ischaemic heart disease-progress in 20 years. Am J Clin Nutr 1988; 47: 965-9.
3. Nordestgaard BG, Tybjaerg-Hansen A. IDL, VLDL and chylomicrons in atherosclerosis. Euro J Epidemiol 1982; 8: 92-8.
4. Hennessy LK, Osada J, Ordovas JM, et al. Effects of dietary fats and cholesterol on liver lipid content and hepatic apolipoprotein A-I, B, and E and LDL receptor mRNA levels in cebus monkeys. J Lip Res 1992; 33: 351-60.
5. Lairon D. Nutritional and metabolic aspects of postprandial lipemia. Reproduct Nutri Dev 1996; 33: 345-55.
6. Weintraub MS, Grosskopf I, Rassin T, et al. Clearance of chylomicron remnants in normolipidemic patients with coronary artery disease - case control study over three years. Br Med J 1996; 312: 935-9.
7. Cohn JS, Tremblay M, Amiot M, et al. Plasma concentration of apolipoprotein E in intermediate-sized remnant-like lipoproteins in normolipidemic and hyperlipidemic subjects. Arterio Thromb Vasc Biol 1996; 16: 149-59.
8. Mamo JCL, Wheeler JR. Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as smaller macromolecules including low density lipoprotein, high density lipoprotein and albumin. Coron Art Dis 1994; 5: 695-705.
9. Proctor SD, Mamo JCL. Arterial fatty lesions have increased uptake of chylomicron-remnants but not low density lipoprotein. Coron Art Dis 1996; 7: 239-45.
10. Simionescu N, Simionescu M. Cellular interactions of lipoproteins with the vascular endothelium: endocytosis and transcytosis. Targital Diagn Ther 1991; 5: 45-95.
11. Thompson GR. A Handbook of Hyperlipidemia. London: Current Science, 1990; 4-16.
12. Mamo JCL. Atherosclerosis as a post-prandial disease. Endocrin Metab 1995; 2: 229-44.
13. Zilversmit DB. Atherogenesis: a post-prandial phenomenon. Circulation 1979; 3: 473-85.
14. Nordestgaard BG. The vascular endothelial barrier-selective retention of lipoproteins. Curr Opin Livid 1996; 75: 269-73.
15. Mamo JCL, Elsegood CL, Gennat HC, Yu K. Degradation of chylomicron remnants by macrophages occurs via phagocytosis. Biochemistry 1996; 35: 10210-14.
16. Ross R. Cell biology of atherosclerosis. Annu Rev Physiol 1994; 57: 791-804.
17. Karpe F, Steiner G, Uffelman K, Olivecrona T, Hamsten A. Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis 1994; 106: 83-97.
18. Chung BH, Tallis G, Yalamoori V, Anantharamaiah GM, Segrest JP. Liposome-like particles isolated from human atherosclerotic plaques are structurally and compositionally similar to surface remnants of triglyceride rich lipoproteins. Arterio Thromb 1994; 14: 622-35.
19. Yu KCW, Mamo JCL. Killing of arterial smooth muscle cells by chylomicron-remnants. Biochem Biophys Res Comm 1996; 220:68-71.
20. Cabezas MC, deBruin TW, Jansen H, Kock LA, Kortlandt W, Erkelens DW. Impaired chylomicron-remnant clearance in familial combined hyperlipemia. Arterio Thromb 1993; 13: 804-14.
21. Mahley RW. Atherogenic lipoproteins and coronary artery disease: concepts deriving from recent advances in cellular and molecular biology. Circulation 1985; 72: 943-8.
22. Breslow JL, Zannis VI, Sangiacomo TR, Third JLHC, Tracy T, Glueck CJ. Studies of familial type III hyperlipoproteinemia using as a genetic marker the apo E phenotype E2/E2. J Lip Res 1982; 23: 1224-35.
23. Reznik Y, Pousse P, Herrou M, et al. Postprandial lipoprotein metabolism in normotriglyceridemic non-insulin-dependent diabetic patients: influence of apolipoprotein E polymorphism. Metab Clin Exp 1996; 45: 63-71.
24. Simionescu M, Simionescu N. Proatherosclerostic events -Pathobiochemical changes occurring in the arterial wall before monocyte migration. FASEB J 1993; 7: 1359-66.
25. Ji ZS, Sanan DA, Mahley RW. Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver - In vivo role of heparin sulphate proteoglycans. J Lipid Res 1995; 36: 583-92.
26. De Sanctis JB, Blanca I, Bianco NE. Secretion of cytokines by natural killer cells primed with interleukin-2 and stimulated with different lipoproteins. Immunulogy 1997; 90: 526-533.