Soy protein isolate induces CYP3A1 and CYP3A2 in prepubertal rats

Experimental Biology and Medicine

Volumn 231, Issue 1, 2006, Pages 60-69

  Ronis, Martin J ^a,b,c   Chen, Ying ^a,b   Badeaux, Jamie ^a   Laurenzana, Elizabeth ^b   Badger, Thomas M ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

CYP3A; Isoflavones; Rat; Soy protein isolate; Weaning

Indexed keywords

APOPROTEIN; CASEIN; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; DAIDZEIN; GENISTEIN; SOYBEAN PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET; DIET SUPPLEMENTATION; ENZYME ACTIVITY; LIVER MICROSOME; METABOLISM; NONHUMAN; PREPUBERTY; PROTEIN EXPRESSION; RAT; SOYBEAN;

ANIMALIA; GLYCINE MAX;

EID: 30344440678     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/153537020623100107     Document Type: Article

References (53)

1. Dorne JL, Walton K, Renwick AG. Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment. Food Chem Toxicol 41:201-224, 2003.
2. Harris RZ, Jang GR, Tsunoda S. Dietary effects on drug metabolism and transport. Clin Pharmacokinet 42:1071-1088, 2003.
3. Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Brit J Clin Pharmacol 46:101-110, 1998.
4. Stevens JC, Hines RN, Gu C, Koukouritaki SB, Manro JR, Tandler PJ, Zaya MJ. Developmental expression of the major human hepatic CYP3A enzymes. J Pharmacol Exp Ther 307:573-582, 2003.
5. Wilkinson GR. Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans. J Pharmacokinet Biopharm 24:475-490, 1996.
6. Kanamori M, Takahashi H, Echizen H. Developmental changes in the liver weight and body weight-normalized clearance of theophylline, phenytoin and cyclosporine in children. Int J Clin Pharmacol Ther 40:485-489, 2002.
7. Van Vleet TR, Kleain PJ, Coulombe RA Jr. Metabolism and cytotoxicity of aflatoxin B1 in cytochrome P450-expressing human lung cells. J Toxicol Environ Health 65:853-867, 2002.
8. Yamazaki H, Inui Y, Wrighton SA, Guengerich FP, Shimada T. Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes. Carcinogenesis 16:2167-2170, 1995.
9. Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. An essential role for nuclear receptors SXR/RXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A 98:3375-3380, 2001.
10. Badawi AF, Cavalieri EL, Rogan EG. Role of human cytochrome P450 1A1, 1A2, 1B1 and 3A4 in the 2-, 4- and 16alpha-hydroxylation of 17beta-estradiol. Metab Clin Exp 50:1001-1003, 2001.
11. Ronis MJJ, Rowlands JC, Hakkak R, Badger TM. Inducibility of hepatic CYP1A enzymes by 3-methylcholanthrene and isosafrole differs in male rats fed diets containing casein, soy protein isolate or whey from conception to adulthood. J Nutr 131:1180-1188, 2001.
12. Rowlands JC, He L, Hakkak R, Ronis MJJ, Badger TM. Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats. J Nutr 131:3281-3287, 2001.
13. Ronis MJJ, Reeves M, Hardy H, Badeaux J, Dahl C, Ferguson M, Badger TM. Effects of diets containing soy protein isolate (SPI) or isoflavones on growth, plasma IGF1, CYP2C11 and CYP4A1 in rat liver following weaning. In: Anzenbacher P, Hudecek J, Eds. Cytochromes P450, Biochemistry, Biophysics and Drug Metabolism. 13th International Conference on Cytochromes P450, Monduzzi Editore, Bologna, Italy, pp287-291, 2003.
14. Ronis MJJ, Rowlands JC, Hakkak R, Badger TM. Altered enzyme expression and glucocorticoid-inducibility of hepatic CYP3A and CYP2B enzymes in male rats fed diets containing soy protein isolate. J Nutr 129:1958-1965, 1999.
15. Ronis MJJ, Chen Y, Jo C-H, Simpson P, Badger TM. Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling rats exposed during early development. J Nutr 134:3270-3276, 2004.
16. Ronis MJJ, Ingelman-Sundberg M. Induction of human P450 enzymes: mechanisms and implications. In: Woolf T, Ed. A Handbook of Human Toxicology. New York: Marcel Decker, pp239-262, 1998.
17. Pascussi JM, Drocourt L, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes: sequential role of glucocorticoid receptor and pregnane X receptor. Eur J Biochem 268:6346-6358, 2001.
18. Ronis MJJ, Ingelman-Sundberg M, Badger TM. Induction, inhibition and suppression of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by ergosterol biosynthesis inhibiting fungicides (EIBFs). Biochem Pharmacol 48:1953-1965, 1994.
19. Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Wilson TM, Collins JL, Kliewer SA. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275:15122-15127, 2000.
20. Mahnke A, Strotkamp D, Roos PH, Hanstein WG, Chabot GG, Nef P. Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Arch Biochem Biophys 337:62-68, 1997.
21. Meredith C, Scott MP, Renwick AB, Price RJ, Lake BG. Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut liver slices. Xenobiotica 33:511-527, 2003.
22. Kim H, Putt DA, Zangar RC, Wolf CR, Guengerich FP, Edwards RJ, Hollenberg PF, Novak RF. Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2 and 2E1 in response to pyridine treatment. Drug Metab Dispos 29:353-360, 2001.
23. Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. Exposure of infants to phytoestrogens from soy-based infant formula. Lancet 350:23-27, 1997.
24. Messina M, Barnes S. The role of soy products in reducing risk of cancer. J Natl Cancer Inst 83:541-546, 1991.
25. Clarkson TB. Soy, soy phytoestrogens and cardiovascular disease. J Nutr 132:566S-569S, 2002.
26. Adlercreutz CH, Goldin SL, Gorbach KA, Hockerstedt S, Watanabe EK, Hamalainen MH, Makkanen TH, Wahala KT, Adlercreutz T. Soybean phytoestrogen intake and cancer risk. J Nutr 125:757S-770S, 1995.
27. Helsby NA, Chipman JK, Gescher A, Kerr D. The isoflavones genistein and equol do not induce xenobiotic-metabolizing enzymes in mouse and human cells. Xenobiotica 27:587-596, 1997.
28. Helsby NA, Chipman JK, Gescher A, Kerr D. Inhibition of mouse and human CYP1A- and CYP2E1-dependent substrate metabolism by the isoflavones genistein and equol. Food Chem Toxicol 36:375-382, 1998.
29. Laurenzana EM, Weis CC, Bryant CW, Newbold R, Delclos KB. Effect of dietary genistein, nonylphenol or ethinyl estradiol on hepatic testosterone metabolism, cytochrome P450 enzymes and estrogen receptor alpha expression. Food Chem Toxicol 40:53-63, 2002.
30. Kishida T, Nagamoto M, Ohtsu Y, Watakabe M, Ohshima D, Nashiki K, Mizushige T, Izumi T, Obata A, Ebihara K. Lack of an inducible effect of dietary soy isoflavones on the mRNA abundance of hepatic cytochrome P450 isozymes in rats. Biosci Biotechnol Biochem 68:508-515, 2004.
31. Kishida T, Nashiki K, Izumi T, Ebihara K. Soy isoflavonoid aglycones genistein and daidzein do not increase the cytochrome P450 content of the liver microsomes of mice. J Agric Food Chem 48:3872-3875, 2000.
32. Shi JZ, Liu GT. Effect of alpha-hederin and sapindoside B on hepatic microsomal cytochrome P450 in mice. Acta Pharmacol Sin 17:264-266, 1996.
33. Kuong DD, Dovgii AI, Adrianov NV, Varenitsa AI, Archakov AI. Induction of cytochrome P450 by triterpensaponins in Vietnamese ginseng. Biokhimiia 56:707-713, 1991.
34. Eliasson E, Mkrtchian S, Halpert J, Ingelman-Sundberg M. Substrateregulated, cAMP-dependent phosphorylation, denaturation and degradation of glucocorticoid-inducible rat liver cytochrome P450 3A1. J Biol Chem 269:18378-18383, 1994.
35. Reeves PG, Nielson FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939-1951, 1993.
36. Chipman JK, Kuruckgy N, Walker CH. The metabolism of dieldrin and two of its analogues: the relationship between rates of microsomal metabolism and rates of excretion of metabolites in the male rat. Biochem Pharmacol 28:1337-1345, 1978.
37. Waxman DJ, Ram PA, Notani G, LeBlanc GA, Alberta JA, Morrissey JJ, Sundseth SS. Pituitary regulation of the male specific steroid 6bhydroxylase P450 2a (gene product IIIA2) in adult rat liver: suppressive influence of growth hormone and thyroxine acting at a pre-translational level. Mol Endocrinol 4:447-457, 1990.
38. Glanazza E, Eberini I, Arnoldi A, Wait R, Sirtori CR. A proteomic investigation of isolated soy proteins with variable effects in experimental and clinical studies. J Nutr 133:9-14, 2003.
39. Li Y, Shay NF. Isoflavone-drug interactions in HepG2 cells and human hepatocytes. FASEB J 18:A851, 2004.
40. Zheng Y, Lee S-O, Verbruggen MA, Murphy PA, Hendrich S. The apparent absorptions of isoflavone glucosides and aglycones are similar in women and are increased by rapid gut transit time and low fecal isoflavone degradation. J Nutr 134:2534-2539, 2004.
41. Rowland I, Faughnan M, Hoey L, Wahala K, Williamson G, Cassidy A. Bioavailability of phyto-oestrogens. Br J Nutr 89:S45-S58, 2003.
42. Badger TM, Ronis MJJ, Fang N. The health effects of dietary isoflavones. In: Zemplini J, Daniel H, Eds. Molecular Nutrition. Wallingford, UK: CAB International, pp201-217, 2003.
43. Badger TM, Ronis MJJ, Hakkak R, Rowlands JC, Korourian S. The health consequences of early soy consumption. J Nutr 132:559S-565S, 2002.
44. Gu L, Laly M, Chang HC, Prior RL, Fang N, Ronis MJJ, Badger TM. Isoflavone conjugates are underestimated in tissues using enzymic hydroysis. J Agric Food Chem 53:6858-6863, 2005.
45. Johnson TN, Tanner MS, Tucker GT. A comparison of the ontogeny of enterocytic and hepatic cytochromes P450 3A in the rat. Biochem Pharmacol 60:1601-1610, 2000.
46. Huss JM, Wang SI, Kasper CB. Differential glucocorticoid responses of CYP3A23 and CYP3A2 are mediated by selective binding of orphan receptors. Arch Biochem Biophys 372:321-332, 1999.
47. Gu L, Prior RL, Fang N, Ronis MJJ, Clarkson TB, Badger TM. Interspecies differences of isoflavone metabolic phenotypes in female rats, pigs, monkeys and humans. FASEB J 19:A446, 2005.
48. Suzuki H, Sugiyama Y. Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine. Eur J Pharm Sci 12:3-12, 2000.
49. Debri K, Boobis AR, Davies DS, Edwards RJ. Distribution of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. Biochem Pharmacol 50:2047-2056, 1995.
50. Mei Q, Richards K, Strong-Basalyga K, Fauty SE, Taylor A, Yamazaki M, Prueksaritanot T, Lin JH, Hochman J. Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2. J Pharm Sci 93:2488-2496, 2004.
51. Aiba T, Toshinaga M, Ishida K, Takehara Y, Hashimoto Y. Intestinal expression and metabolic activity of the CYP3A subfamily in female rats. Biol Pharm Bull 28:311-315, 2005.
52. Takara K, Ohnishi N, Horibe S, Yokoyama T. Expression profiles of drug metabolizing CYP3a and drug efflux transporter multidrug resistance 1 subfamily mRNAs in small intestine. Drug Metab Dispos 31:1235-1239, 2003.
53. Xu H, Harper PA, Kim RB, Kliewer SA, Lonnerdal BL, Ito S. Effects of human milk and formula on transcriptional regulation of cytochrome P450 3A4. FASEB J 18:A1202, 2004.