Intestinal expression and metabolic activity of the CYP3A subfamily in female rats

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 2, 2005, Pages 311-315

  Aiba, Tetsuya ^a   Yoshinaga, Manko ^a   Ishida, Kazuya ^a   Takehara, Yutaka ^a   Hashimoto, Yukiya ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

CYP3A9; Intestinal metabolism; Rifabutin; Testosterone

Indexed keywords

6BETA HYDROXYTESTOSTERONE; CYTOCHROME P450 3A; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A9; RIFABUTIN; TESTOSTERONE; UNCLASSIFIED DRUG; CYP3A13 PROTEIN, RAT; MESSENGER RNA; N DEMETHYLASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME METABOLISM; ENZYME SUBSTRATE; FEMALE; GENDER; HYDROXYLATION; INTESTINE CELL; INTESTINE FUNCTION; LIVER METABOLISM; MALE; METABOLIC RATE; METABOLIC REGULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; ENZYME SPECIFICITY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INTESTINE; LIVER MICROSOME; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTESTINES; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, WISTAR; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

EID: 19444375003     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.28.311     Document Type: Article

References (27)

1. Manurel P., "Cytochromes P450," ed. by Ioannides C., CRC Press, New York, 1996, pp. 241-270.
2. Paine M. F., Khalighi M., Fisher J. M., Shen D. D., Kunze K. L., Marsh C. L., Perkins J. D., Thummel K. E., J. Pharmacol. Exp. Ther., 283, 1552-1562 (1997).
3. Lampen A., Christians U., Guengerich F. P., Watkins P. B., Kolars J. C., Bader A., Gonschior A. K., Dralle H., Hackbarth I., Sewing K. F., Drug Metab. Dispos., 23, 1315-1324 (1995).
4. Wu C. Y., Benet L. Z., Hebert M. F., Gupta S. K., Rowland M., Gomez D. Y., Wacher V. J., Clin. Pharmacol. Ther., 58, 492-497 (1995).
5. Lown K. S., Bailey D. G., Fontana R. J., Janardan S. K., Adair C. H., Fortlage L. A., Brown M. B., Guo W., Watkins P. B., J. Clin. Invest., 99, 2545-2553 (1997).
6. Paine M. F., Shen D. D., Kunze K. L., Perkins J. D., Marsh C. L., McVicar J. P., Barr D. M., Gillies B. S., Thummel K. E., Clin. Pharmacol. Ther., 60, 14-24 (1996).
7. Hashimoto Y., Sasa H., Shimomura M., Inui K., Pharm. Res., 15, 1609-1613 (1998).
8. Lin J. H., Drug Metab. Dispos., 26, 1202-1212 (1998).
9. Aiba T., Takehara Y., Okuno M., Hashimoto Y., Pharm. Res., 20, 745-748 (2003).
10. Takara K., Ohnishi N., Horibe S., Yokoyama T., Drug Metab. Dispos., 31, 1235-1239 (2003).
11. Ribeiro V., Lechner M. C., Arch. Biochem. Biophys., 293, 147-152 (1992).
12. Kamataki T., Maeda K., Shimada M., Nagai T., Kato R., J. Biochem., 96, 1939-1942 (1984).
13. Waxman D. J., Dannan G. A., Guengerich F. P., Biochemistry, 24, 4409-4417 (1985).
14. Wang H., Strobel H. W., Arch. Biochem. Biophys., 344, 365-372 (1997).
15. Jager W., Correia M. A., Bornheim L. M., Mahnke A., Hanstein W. G., Xue L., Benet L. Z., Drug Metab. Dispos., 27, 1505-1511 (1999).
16. Mahnke A., Strotkamp D., Roos P. H., Hanstein W. G., Chabot G. G., Nef P., Arch. Biochem. Biophys., 337, 62-68 (1997).
17. Anakk S., Ku C. Y., Vore M., Strobel H. W., J. Pharmacol. Exp. Ther., 305, 703-709 (2003).
18. Wright M. C., Edwards R. J., Pimenta M., Ribeiro V., Ratra G. S., Lechner M. C., Paine A. J., Biochem. Pharmacol., 54, 841-846 (1997).
19. Debri K., Boobis A. R., Davies D. S., Edwards R. J., Biochem. Pharmacol., 50, 2047-2056 (1995).
20. Iatsimirskaia E., Tulebaev S., Storozhuk E., Utkin I., Smith D., Gerber N., Koudriakova T., Clin. Pharmacol. Ther., 61, 554-562 (1997).
21. Koudriakova T., Iatsimirskaia E., Tulebaev S., Spetie D., Utkin I., Mullet D., Thompson T., Vouros P., Gerber N., J. Pharmacol. Exp. Ther., 279, 1300-1309 (1996).
22. Nagata K., Ogino M., Shimada M., Miyata M., Gonzalez F. J., Yamazoe Y., Arch. Biochem. Biophys., 362, 242-253 (1999).
23. Hoen P. A. C.'t, Bijsterbosch M. K., van Berkel T. J., Vermeulen N. P., Commandeur J. N., J. Pharmacol. Exp. Ther., 299, 921-927 (2001).
24. Hashimoto Y., Aiba T., Yasuhara M., Hori R., J. Pharm. Pharmacol., 53, 805-813 (2001).
25. Okabe H., Hasunuma M., Hashimoto Y., Pharm. Res., 20, 1591-1594 (2003).
26. Gushchin G. V., Gushchin M. I., Gerber N., Boyd R. T., Biochem. Biophys. Res. Commun., 255, 394-398 (1999).
27. Matsubara T., Kim H. J., Miyata M., Shimada M., Nagata K., Yamazoe Y., J. Pharmacol. Exp. Ther., 309, 1282-1290 (2004).