Phenolic P2/P3 core motif as thrombin inhibitors - Design, synthesis, and X-ray co-crystal structure

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 4, 2006, Pages 1032-1036

  Hanessian, Stephen ^a   Therrien, Eric ^a   Van Otterlo, Willem A L ^a   Bayrakdarian, Malken ^a   Nilsson, Ingemar ^b   Fjellström, Ola ^b   Xue, Yafeng ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Inhibitor; Phenol; Sulfonamide; Thrombin; Trypsin

Indexed keywords

NAPHTHYLSULFONAMIDE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; ANTICOAGULANT AGENT; ANTITHROMBIN; PHENOL DERIVATIVE; THROMBIN;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTICOAGULANTS; ANTITHROMBINS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENOLS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 30344434045     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.10.082     Document Type: Article

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