Amidinohydrazones as guanidine bioisosteres: Application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 1, 2000, Pages 1-4

  Soll, Richard M ^a   Lu, Tianobao ^a   Tomczuk, Bruce ^a   Illig, Carl R ^a   Fedde, Cynthia ^a   Eisennagel, Stephen ^a   Bone, Roger ^a   Murphy, Larry ^a   Spurlino, John ^a   Salemme, F Raymond ^a  

^a Eagleview Corporate Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANIDINE DERIVATIVE; HYDRAZONE DERIVATIVE; THROMBIN INHIBITOR;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING TIME; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HYDROGEN BOND; NONHUMAN; RABBIT;

ADMINISTRATION, ORAL; AMIDINES; ANIMALS; BINDING SITES; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DOGS; FIBRINOLYTIC AGENTS; GUANIDINES; KINETICS; RABBITS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THROMBIN; TRYPSIN INHIBITORS;

CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS;

EID: 0034598328     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00632-0     Document Type: Article

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