메뉴 건너뛰기




Volumn 4, Issue 6, 2005, Pages 831-841

Towards a therapeutic breast cancer vaccine: The next steps

Author keywords

Breast cancer; Cancer vaccines; Combinatorial immunotherapy; Immune modulation; Immune tolerance

Indexed keywords

BEVACIZUMAB; BREAST CANCER VACCINE; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DENDRITIC CELL VACCINE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; GLUCOCORTICOID TUMOR NECROSIS FACTOR RECEPTOR; GLYCOPROTEIN GP 100; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; KEYHOLE LIMPET HEMOCYANIN; MUCIN 1; PACLITAXEL; TOLL LIKE RECEPTOR; TRASTUZUMAB; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR VACCINE; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTINEOPLASTIC AGENT; CANCER VACCINE; MONOCLONAL ANTIBODY;

EID: 29944440750     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.4.6.831     Document Type: Review
Times cited : (4)

References (118)
  • 2
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D, Clark G, Wong S et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177-182 (1987).
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.1    Clark, G.2    Wong, S.3
  • 3
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon D, Godolphin W, Jones L et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707-712 (1989).
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.1    Godolphin, W.2    Jones, L.3
  • 4
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou C, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. 98, 10869-10874 (2001). Important report characterizing the clinical heterogeneity of breast cancers at the genetic level.
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.2    Tibshirani, R.3
  • 5
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie T, Tibshirani R, Parker J et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl. Acad. Sci. 100, 8418-8423 (2003).
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 6
    • 13844273459 scopus 로고    scopus 로고
    • Trastuzumab in breast cancer
    • Emens L, Davidson N. Trastuzumab in breast cancer. Oncology 18, 1117-1128 (2004). Comprehensive review of the clinical utility of trastuzumab in metastatic breast cancer.
    • (2004) Oncology , vol.18 , pp. 1117-1128
    • Emens, L.1    Davidson, N.2
  • 7
    • 20644447815 scopus 로고    scopus 로고
    • Monoclonal antibody therapies shine in breast cancer clinical trials
    • Hampton T. Monoclonal antibody therapies shine in breast cancer clinical trials. JAMA 293, 2985-2989 (2005).
    • (2005) JAMA , vol.293 , pp. 2985-2989
    • Hampton, T.1
  • 8
    • 0037233233 scopus 로고    scopus 로고
    • Trastuzumab, an appropriate first-line single-agent therapy for HER2-overexpressing breast cancer
    • Arteaga C. Trastuzumab, an appropriate first-line single-agent therapy for HER2-overexpressing breast cancer. Breast Cancer Res. 5, 96-100 (2003).
    • (2003) Breast Cancer Res. , vol.5 , pp. 96-100
    • Arteaga, C.1
  • 9
    • 0033559619 scopus 로고    scopus 로고
    • Monoclonal antilbody to HER-2/neu receptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene
    • Pietras R, Poen J, Gallardo D et al. Monoclonal antilbody to HER-2/neu receptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res. 59, 1347-1355 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 1347-1355
    • Pietras, R.1    Poen, J.2    Gallardo, D.3
  • 10
    • 0035213562 scopus 로고    scopus 로고
    • DNA strand breaks and cell cycle perturbation in Herceptin treated breast cancer cell lines
    • Mayfield S, Vaughn J, Kute T. DNA strand breaks and cell cycle perturbation in Herceptin treated breast cancer cell lines. Breast Cancer Res. Treat. 70, 123-129 (2001).
    • (2001) Breast Cancer Res. Treat. , vol.70 , pp. 123-129
    • Mayfield, S.1    Vaughn, J.2    Kute, T.3
  • 11
    • 0037108866 scopus 로고    scopus 로고
    • Enhanced sensitization to taxol-induced apoptosis by Herceptin pretreatment in ErbB2-overexpressing breast cancer cells
    • Lee S, Yang W, Lan K et al. Enhanced sensitization to taxol-induced apoptosis by Herceptin pretreatment in ErbB2-overexpressing breast cancer cells. Cancer Res. 62, 5703-5710 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 5703-5710
    • Lee, S.1    Yang, W.2    Lan, K.3
  • 12
    • 20244378529 scopus 로고    scopus 로고
    • Neoadjuvant trastuzumab induces apoptosis in primary breast cancers
    • Mohsin S, Weiss H, Gutierrez M et al. Neoadjuvant trastuzumab induces apoptosis in primary breast cancers. J Clin. Oncol. 10, 2460-2468 (2005).
    • (2005) J. Clin. Oncol. , vol.10 , pp. 2460-2468
    • Mohsin, S.1    Weiss, H.2    Gutierrez, M.3
  • 14
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • Clynes R, Towers T, Presta L, Ravetch J. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nature Med. 6, 443-446 (2000).
    • (2000) Nature Med. , vol.6 , pp. 443-446
    • Clynes, R.1    Towers, T.2    Presta, L.3    Ravetch, J.4
  • 15
    • 4444372733 scopus 로고    scopus 로고
    • Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2
    • Gennari R, Menard S, Fagnoni F et al. Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2. Clin Cancer Res. 10, 5650-5655 (2004).
    • (2004) Clin Cancer Res. , vol.10 , pp. 5650-5655
    • Gennari, R.1    Menard, S.2    Fagnoni, F.3
  • 16
    • 1842426004 scopus 로고    scopus 로고
    • Trastuzumab (Herceptin) enhances class I-restricted antigen presentation recognized by HER-2/neu-specific T-lymphocytes
    • Kono K, Sato E, Naganuma H et al. Trastuzumab (Herceptin) enhances class I-restricted antigen presentation recognized by HER-2/neu-specific T-lymphocytes. Clin. Cancer Res. 10, 2538-2544 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2538-2544
    • Kono, K.1    Sato, E.2    Naganuma, H.3
  • 17
    • 0037089544 scopus 로고    scopus 로고
    • Antihuman epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab enhances cytolytic activity of Class I-restricted HER2-specific T-lymphocytes against HER2-overexpressing tumor cells
    • zum Buschenfelde C, Hermann C, Schmidt B, Peschel C, Bernhard H. Antihuman epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab enhances cytolytic activity of Class I-restricted HER2-specific T-lymphocytes against HER2-overexpressing tumor cells. Cancer Res. 62, 2244-2247 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 2244-2247
    • Zum Buschenfelde, C.1    Hermann, C.2    Schmidt, B.3    Peschel, C.4    Bernhard, H.5
  • 18
    • 0032838613 scopus 로고    scopus 로고
    • Immune selection after antigen-specific immunotherapy of melanoma
    • Riker A, Cormier J, Panelli M et al. Immune selection after antigen-specific immunotherapy of melanoma. Surgery 126, 112-120 (1999).
    • (1999) Surgery , vol.126 , pp. 112-120
    • Riker, A.1    Cormier, J.2    Panelli, M.3
  • 19
    • 0033055251 scopus 로고    scopus 로고
    • Therapy of B-cell lymphoma with anti-CD20 antibodies can result in the loss of CD20 antigen expression
    • Davis T, Czerwinski D, Levy R. Therapy of B-cell lymphoma with anti-CD20 antibodies can result in the loss of CD20 antigen expression. Clin. Cancer Res. 5, 611-615 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 611-615
    • Davis, T.1    Czerwinski, D.2    Levy, R.3
  • 20
    • 0842282556 scopus 로고    scopus 로고
    • Neu antigen-variants can be generated after neu-specific antibody therapy in neu transgenic mice
    • Knutson K, Almand B, Dang Y, Disis M. Neu antigen-variants can be generated after neu-specific antibody therapy in neu transgenic mice. Cancer Res. 64, 1146-1151 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 1146-1151
    • Knutson, K.1    Almand, B.2    Dang, Y.3    Disis, M.4
  • 21
    • 0036360019 scopus 로고    scopus 로고
    • The enemy within: Keeping self-reactive T-cells at bay in the periphery
    • Walker L, Abbas A. The enemy within: keeping self-reactive T-cells at bay in the periphery. Nature Rev. Immunol. 21, 11-19 (2001).
    • (2001) Nature Rev. Immunol. , vol.21 , pp. 11-19
    • Walker, L.1    Abbas, A.2
  • 22
    • 0031963994 scopus 로고    scopus 로고
    • Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity
    • Morgan D, Kreuwel H, Fleck S et al. Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity. J. Immunol. 160, 643-651 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 643-651
    • Morgan, D.1    Kreuwel, H.2    Fleck, S.3
  • 23
    • 0028824098 scopus 로고
    • Low avidity antigen recognition of self antigen by T-cells permits escape from central tolerance
    • Lui G, Fairchild P, Smith R et al. Low avidity antigen recognition of self antigen by T-cells permits escape from central tolerance. Immunity 3, 407-415 (1995).
    • (1995) Immunity , vol.3 , pp. 407-415
    • Lui, G.1    Fairchild, P.2    Smith, R.3
  • 26
    • 0035869571 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances the CTL responses to the p53 self-tumor antigen
    • Hernandez J, Ko A, Sherman L. CTLA-4 blockade enhances the CTL responses to the p53 self-tumor antigen. J. Immunol. 166, 3908-3914 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3908-3914
    • Hernandez, J.1    Ko, A.2    Sherman, L.3
  • 27
    • 11144356391 scopus 로고    scopus 로고
    • High vaccination efficiency of low affinity epitopes in antitumor immunotherapy
    • Gross D, Graff-Dubois S, Opolon P et al. High vaccination efficiency of low affinity epitopes in antitumor immunotherapy. J. Clin. Invest. 113, 425-433 (2004).
    • (2004) J. Clin. Invest. , vol.113 , pp. 425-433
    • Gross, D.1    Graff-Dubois, S.2    Opolon, P.3
  • 28
    • 21144454780 scopus 로고    scopus 로고
    • + T-cells to the antitumor immune response
    • + T-cells to the antitumor immune response. J. Exp. Med. 201, 1591-1602 (2005). Demonstrates the ability of cyclophosphamide to abrogate regulatory T-cells and facilitate the development of high-avidity antigen-specific effector T-cells by vaccination.
    • (2005) J. Exp. Med. , vol.201 , pp. 1591-1602
    • Ercolini, A.1    Ladle, B.2    Manning, E.3
  • 29
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T-cells and mechanisms of immune system control
    • O'Garra A, Vierira P. Regulatory T-cells and mechanisms of immune system control. Nature Med. 10, 801-805 (2004). Detailed review of regulatory T-cells.
    • (2004) Nature Med. , vol.10 , pp. 801-805
    • O'Garra, A.1    Vierira, P.2
  • 30
    • 0742286811 scopus 로고    scopus 로고
    • Derangement of immune responses by myeloid suppressor cells
    • Serafini P, De Santo C, Marigo I et al. Derangement of immune responses by myeloid suppressor cells. Cancer Immunol. Immunother. 53, 64-72 (2004).
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 64-72
    • Serafini, P.1    De Santo, C.2    Marigo, I.3
  • 32
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T-cell responses
    • Watts T. TNF/TNFR family members in costimulation of T-cell responses. Ann. Rev. Immunol. 23, 23-68 (2005).
    • (2005) Ann. Rev. Immunol. , vol.23 , pp. 23-68
    • Watts, T.1
  • 33
    • 8644265838 scopus 로고    scopus 로고
    • Evidence for immune defects in breast and lung cancer patients
    • Caras I, Grigorescu A, Stavaru K et al. Evidence for immune defects in breast and lung cancer patients. Cancer Immunol. Immunother. 53, 1146-1152 (2004).
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 1146-1152
    • Caras, I.1    Grigorescu, A.2    Stavaru, K.3
  • 34
    • 20444479848 scopus 로고    scopus 로고
    • Peripheral blood IFN-γ-secreting Vα24 Vβ1 NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load
    • Molling J, Kolgen W, van der Vliet H et al. Peripheral blood IFN-γ-secreting Vα24 Vβ1 NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load. Int. J. Cancer 116, 87-93 (2005).
    • (2005) Int. J. Cancer , vol.116 , pp. 87-93
    • Molling, J.1    Kolgen, W.2    Van Der Vliet, H.3
  • 35
    • 0037312480 scopus 로고    scopus 로고
    • Increase of regulatory T-cells in the peripheral blood of cancer patients
    • Wolf A, Wolf D, Steurer M et al. Increase of regulatory T-cells in the peripheral blood of cancer patients. Clin. Cancer Res. 9, 606-612 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 606-612
    • Wolf, A.1    Wolf, D.2    Steurer, M.3
  • 36
    • 9444265268 scopus 로고    scopus 로고
    • Dendritic cell infiltration and prognosis of early stage breast cancer
    • Treilleux I, Blay J, Bendriss-Vermare N et al. Dendritic cell infiltration and prognosis of early stage breast cancer. Clin. Cancer Res. 10, 7466-7474 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 7466-7474
    • Treilleux, I.1    Blay, J.2    Bendriss-Vermare, N.3
  • 37
    • 2442696835 scopus 로고    scopus 로고
    • Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer
    • Pockaj B, Basu G, Pathangey L et al. Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer. Ann. Surg. Oncol. 11, 328-339 (2004).
    • (2004) Ann. Surg. Oncol. , vol.11 , pp. 328-339
    • Pockaj, B.1    Basu, G.2    Pathangey, L.3
  • 38
    • 16644371597 scopus 로고    scopus 로고
    • Expression of HLA class I antigen and proteasome subunits LMP-2 and LMP-10 in primary vs. metastatic breast carcinoma lesions
    • Gobbi G, Mirandola P, Micheloni C et al. Expression of HLA class I antigen and proteasome subunits LMP-2 and LMP-10 in primary vs. metastatic breast carcinoma lesions. Int. J. Oncol. 25, 1625-1629 (2004).
    • (2004) Int. J. Oncol. , vol.25 , pp. 1625-1629
    • Gobbi, G.1    Mirandola, P.2    Micheloni, C.3
  • 39
    • 1642535582 scopus 로고    scopus 로고
    • HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway
    • Hermann F, Lehr H, Drexler I et al. HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway. Cancer Res. 64, 215-220 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 215-220
    • Hermann, F.1    Lehr, H.2    Drexler, I.3
  • 40
    • 0042836552 scopus 로고    scopus 로고
    • Elevated serum arginase activity levels in patients with breast cancer
    • Polat M, Taysi S, Polat S, Boyuk A, Bakan E. Elevated serum arginase activity levels in patients with breast cancer. Surgery Today 33, 655-661 (2003).
    • (2003) Surgery Today , vol.33 , pp. 655-661
    • Polat, M.1    Taysi, S.2    Polat, S.3    Boyuk, A.4    Bakan, E.5
  • 42
    • 0031788449 scopus 로고    scopus 로고
    • CD40 is functionally expressed on human breast carcinomas: Variable inducibility by cytokines and enhancement of Fas-mediated apoptosis
    • Wingett D, Vestal R, Forcier K, Hadjokas N, Nielson C. CD40 is functionally expressed on human breast carcinomas: variable inducibility by cytokines and enhancement of Fas-mediated apoptosis. Breast Cancer Res. Treat. 50, 27-36 (1998).
    • (1998) Breast Cancer Res. Treat. , vol.50 , pp. 27-36
    • Wingett, D.1    Vestal, R.2    Forcier, K.3    Hadjokas, N.4    Nielson, C.5
  • 43
    • 16344391363 scopus 로고    scopus 로고
    • B7-H4 is highly expressed in ductal and lobular breast cancer
    • Tringler B, Zhuo S, Pilkington G et al. B7-H4 is highly expressed in ductal and lobular breast cancer. Clin. Cancer Res. 11, 1842-1848 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1842-1848
    • Tringler, B.1    Zhuo, S.2    Pilkington, G.3
  • 44
    • 18844373949 scopus 로고    scopus 로고
    • The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation
    • Salceda S, Tang T, Kmet M et al. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Exp. Cell Res. 306, 128-141 (2005).
    • (2005) Exp. Cell Res. , vol.306 , pp. 128-141
    • Salceda, S.1    Tang, T.2    Kmet, M.3
  • 45
    • 1542472888 scopus 로고    scopus 로고
    • Towards a breast cancer vaccine: Work in progress
    • Emens L, Jaffee E. Towards a breast cancer vaccine: work in progress. Oncology 17, 1200-1211 (2003). Comprehensive review of clinical trials testing breast cancer vaccines.
    • (2003) Oncology , vol.17 , pp. 1200-1211
    • Emens, L.1    Jaffee, E.2
  • 46
    • 0028144438 scopus 로고
    • Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer
    • Disis M, Calenoff E, McLaughlin G et al. Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res. 54, 16-20 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 16-20
    • Disis, M.1    Calenoff, E.2    McLaughlin, G.3
  • 47
    • 0030657467 scopus 로고    scopus 로고
    • High-titer HER-2/neu protein-specific antibody can be detected in patients with early-stage breast cancer
    • Disis M, Pupa S, Gralow J et al. High-titer HER-2/neu protein-specific antibody can be detected in patients with early-stage breast cancer. J. Clin. Oncol. 15, 3363-3367 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , pp. 3363-3367
    • Disis, M.1    Pupa, S.2    Gralow, J.3
  • 48
    • 0346364653 scopus 로고    scopus 로고
    • Rationale for the clinical development of STn-KLH (Theratope®) and antiMUC-1 vaccines in breast cancer
    • Miles D, Papazisi K. Rationale for the clinical development of STn-KLH (Theratope®) and antiMUC-1 vaccines in breast cancer. Clin. Breast Cancer 3(Suppl. 4), S134-S138 (2003).
    • (2003) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 4
    • Miles, D.1    Papazisi, K.2
  • 50
    • 0242432329 scopus 로고    scopus 로고
    • Nonredundant roles of antibody, cytokines, and perforin in the eradication of established HER-2/neu carcinomas
    • Curcio C, Di Carlo E, Clynes R et al. Nonredundant roles of antibody, cytokines, and perforin in the eradication of established HER-2/neu carcinomas. J. Clin. Invest. 111, 1116-1118 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 1116-1118
    • Curcio, C.1    Di Carlo, E.2    Clynes, R.3
  • 51
    • 20144388865 scopus 로고    scopus 로고
    • Cure of mammary carcinomas in HER-2 transgenic mice through sequential stimulation of innate (neoadjuvant interleukin-12) and adaptive (DNA vaccine electroporation) immunity
    • Spadaro M, Ambrosino E, Iezzi M et al. Cure of mammary carcinomas in HER-2 transgenic mice through sequential stimulation of innate (neoadjuvant interleukin-12) and adaptive (DNA vaccine electroporation) immunity. Clin. Cancer Res. 11, 1941-1952 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1941-1952
    • Spadaro, M.1    Ambrosino, E.2    Iezzi, M.3
  • 52
    • 0033048807 scopus 로고    scopus 로고
    • Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine
    • Disis M, Grabstein K, Sleath P, Cheever M. Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine. Clin. Cancer Res. 5, 1289-1297 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1289-1297
    • Disis, M.1    Grabstein, K.2    Sleath, P.3    Cheever, M.4
  • 53
    • 0034006703 scopus 로고    scopus 로고
    • Delayed-type hypersensitivity response is a predictor of peripheral blood T-cell immunity after HER-2/neu peptide immunization
    • Disis M, Schiffman K, Gooley T et al. Delayed-type hypersensitivity response is a predictor of peripheral blood T-cell immunity after HER-2/neu peptide immunization. Clin. Cancer Res. 6, 1347-1350 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1347-1350
    • Disis, M.1    Schiffman, K.2    Gooley, T.3
  • 54
    • 0036605567 scopus 로고    scopus 로고
    • Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines
    • Disis M, Gooley T, Rinn K et al. Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines. J. Clin. Oncol. 20, 2624-2632 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2624-2632
    • Disis, M.1    Gooley, T.2    Rinn, K.3
  • 55
    • 0036098003 scopus 로고    scopus 로고
    • Immunization of cancer patients with a HER-2/neu HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity
    • Knutson K, Schiffman K, Cheever M, Disis M. Immunization of cancer patients with a HER-2/neu HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity. Clin. Cancer Res. 8, 1014-1018 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1014-1018
    • Knutson, K.1    Schiffman, K.2    Cheever, M.3    Disis, M.4
  • 56
    • 0035113705 scopus 로고    scopus 로고
    • Immunisation with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients
    • Knutson K, Schiffman K, Disis M. Immunisation with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J. Clin. Invest. 107, 477-484 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 477-484
    • Knutson, K.1    Schiffman, K.2    Disis, M.3
  • 57
    • 0345060456 scopus 로고    scopus 로고
    • Immunisation of cancer patients with HER-2/neu-derived peptides demonstrating high affinity binding to multiple class II alleles
    • Salazar L, Fikes J, Southwood S et al. Immunisation of cancer patients with HER-2/neu-derived peptides demonstrating high affinity binding to multiple class II alleles. Clin. Cancer Res. 9, 5559-5565 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5559-5565
    • Salazar, L.1    Fikes, J.2    Southwood, S.3
  • 58
    • 4544252430 scopus 로고    scopus 로고
    • Humoral epitope-spreading following immunization with a HER-27/neu peptide based vaccine in cancer patients
    • Disis M, Goodell V, Schiffman K, Knutson K. Humoral epitope-spreading following immunization with a HER-27/neu peptide based vaccine in cancer patients. J. Clin. Immunol. 24, 571-578 (2004).
    • (2004) J. Clin. Immunol. , vol.24 , pp. 571-578
    • Disis, M.1    Goodell, V.2    Schiffman, K.3    Knutson, K.4
  • 59
    • 0036847689 scopus 로고    scopus 로고
    • Toxicity, immunogenicity and induction of E75-specific tumor-lytic CTLs by HER-2 peptide E75 (369-377) combined with granulocyte-macrophage colony stimulating factor in HLA-A2* patients with metastatic breast and ovarian cancer
    • Murray J, Gillogly M, Przepiorka D et al. Toxicity, immunogenicity and induction of E75-specific tumor-lytic CTLs by HER-2 peptide E75 (369-377) combined with granulocyte-macrophage colony stimulating factor in HLA-A2* patients with metastatic breast and ovarian cancer. Clin. Cancer Res. 8, 3407-3418 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3407-3418
    • Murray, J.1    Gillogly, M.2    Przepiorka, D.3
  • 60
    • 3042745485 scopus 로고    scopus 로고
    • Effect of dose on immune response in patients vaccinated with a HER-2/neu intracellular domain protein-based vaccine
    • Disis M, Schiffman K, Guthrie K et al. Effect of dose on immune response in patients vaccinated with a HER-2/neu intracellular domain protein-based vaccine. J. Clin. Oncol. 22, 1916-1925 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1916-1925
    • Disis, M.1    Schiffman, K.2    Guthrie, K.3
  • 61
    • 5644272420 scopus 로고    scopus 로고
    • HER2 dendritic cell vaccines
    • Morse M, Clay T, Collin K et al. HER2 dendritic cell vaccines. Clin. Breast Cancer 3(Suppl. 4), S164-S172 (2003).
    • (2003) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 4
    • Morse, M.1    Clay, T.2    Collin, K.3
  • 62
    • 0037445114 scopus 로고    scopus 로고
    • Immunotherapy of advanced breast cancer with a heterophilic ganglioside (NeuGcGM3) cancer vaccine
    • Carr A, Rodriguez E, del Carmen Arango M et al. Immunotherapy of advanced breast cancer with a heterophilic ganglioside (NeuGcGM3) cancer vaccine. J. Clin. Oncol. 21, 1015-1021 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1015-1021
    • Carr, A.1    Rodriguez, E.2    Del Carmen Arango, M.3
  • 63
    • 0034071575 scopus 로고    scopus 로고
    • Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21
    • Gilewski T, Adluri S, Ragupathi G et al. Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21. Clin. Cancer Res. 6, 1693-1701 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1693-1701
    • Gilewski, T.1    Adluri, S.2    Ragupathi, G.3
  • 64
    • 0035853030 scopus 로고    scopus 로고
    • Immunization of metastatic breast cancer patients with a fully synthetic Globo H conjugate: A Phase I trial
    • Gilewski T, Ragupathi G, Bhuta S et al. Immunization of metastatic breast cancer patients with a fully synthetic Globo H conjugate: a Phase I trial. Proc. Natl. Acad. Sci. 98, 3270-3275 (2001).
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 3270-3275
    • Gilewski, T.1    Ragupathi, G.2    Bhuta, S.3
  • 65
    • 0033032313 scopus 로고    scopus 로고
    • Specificity analysis of sera from breast cancer patients vaccinated with MUC1-KLH plus QS-21
    • Adluri S, Gilewski T, Zhang S et al. Specificity analysis of sera from breast cancer patients vaccinated with MUC1-KLH plus QS-21. Br. J. Cancer 79, 1806-1812 (1999).
    • (1999) Br. J. Cancer , vol.79 , pp. 1806-1812
    • Adluri, S.1    Gilewski, T.2    Zhang, S.3
  • 66
    • 0035399603 scopus 로고    scopus 로고
    • Antibody-dependent cell-mediated cytotoxicity can be induced by MUC1 peptide vaccination of breast cancer patients
    • Snijdewint F, von Mensdorff-Pouilly S, Karuntu-Wanamarta A et al. Antibody-dependent cell-mediated cytotoxicity can be induced by MUC1 peptide vaccination of breast cancer patients. Int. J. Cancer 93, 97-106 (2001).
    • (2001) Int. J. Cancer , vol.93 , pp. 97-106
    • Snijdewint, F.1    Von Mensdorff-Pouilly, S.2    Karuntu-Wanamarta, A.3
  • 67
    • 0037050724 scopus 로고    scopus 로고
    • Reevaluation of the cellular immune response in breast cancer patients vaccinated with MUC1
    • Muselli C, Ragupathi G, Gilewski T et al. Reevaluation of the cellular immune response in breast cancer patients vaccinated with MUC1. Int. J. Cancer 97, 660-667 (2002).
    • (2002) Int. J. Cancer , vol.97 , pp. 660-667
    • Muselli, C.1    Ragupathi, G.2    Gilewski, T.3
  • 68
    • 0029804156 scopus 로고    scopus 로고
    • A randomized Phase II study of Sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer
    • Miles D, Towlson K, Graham R et al. A randomized Phase II study of Sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer. Br. J. Cancer 74, 1292-1296 (1996).
    • (1996) Br. J. Cancer , vol.74 , pp. 1292-1296
    • Miles, D.1    Towlson, K.2    Graham, R.3
  • 69
    • 1842830727 scopus 로고    scopus 로고
    • An international, randomized Phase III clinical trial of STn-KLH (Theratope) therapeutic cancer vaccine in metastatic breast cancer patients
    • Miles D, Ibrahim N, Roche U et al. An international, randomized Phase III clinical trial of STn-KLH (Theratope) therapeutic cancer vaccine in metastatic breast cancer patients. Breast Cancer Res. Treat. 82, 36 (2003).
    • (2003) Breast Cancer Res. Treat. , vol.82 , pp. 36
    • Miles, D.1    Ibrahim, N.2    Roche, U.3
  • 70
    • 0346994554 scopus 로고    scopus 로고
    • Clinical development of the STn-KLH vaccine (Theratope®)
    • Ibrahim, N, Murray, J. Clinical development of the STn-KLH vaccine (Theratope®). Clin. Breast Cancer 3(Suppl. 4), S139-S143 (2003).
    • (2003) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 4
    • Ibrahim, N.1    Murray, J.2
  • 71
    • 9644286616 scopus 로고    scopus 로고
    • Humoral immune responses to naturally occurring STn in metastatic breast cancer patients (MBC pts) treated with STn-KLH vaccine
    • Ibrahim N, Murray J, Parker J, Finke L, Miles D. Humoral immune responses to naturally occurring STn in metastatic breast cancer patients (MBC pts) treated with STn-KLH vaccine. Proc. Am. Soc. Clin. Oncol. 23, 174 (2004).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 174
    • Ibrahim, N.1    Murray, J.2    Parker, J.3    Finke, L.4    Miles, D.5
  • 72
    • 20344375616 scopus 로고    scopus 로고
    • Long-term follow-up of patients concomitantly treated with hormone therapy in a prospective controlled randomized multicenter clinical study comparing STn-KLH vaccine with KLH control in stage IV breast cancer following first chemotherapy
    • Mayordomo J, Tres A, Miles D, Finke L, Jenkins H. Long-term follow-up of patients concomitantly treated with hormone therapy in a prospective controlled randomized multicenter clinical study comparing STn-KLH vaccine with KLH control in stage IV breast cancer following first chemotherapy. Proc. Am. Soc. Clin. Oncol. 23, 188 (2004).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 188
    • Mayordomo, J.1    Tres, A.2    Miles, D.3    Finke, L.4    Jenkins, H.5
  • 73
    • 3042728833 scopus 로고    scopus 로고
    • Vaccination with p53 peptide-pulsed dendritic cells, of patients with advanced breast cancer: Report from a Phase I study
    • Svane I, Pedersen A, Johnson HE et al. Vaccination with p53 peptide-pulsed dendritic cells, of patients with advanced breast cancer: report from a Phase I study. Cancer Immunol. Immunother. 53, 633-641 (2004).
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 633-641
    • Svane, I.1    Pedersen, A.2    Johnson, H.E.3
  • 74
    • 0030951625 scopus 로고    scopus 로고
    • Tumor cell number and viability as quality and efficacy parameters of autologous virus-modified cancer vaccines in patients with breast or ovarian cancer
    • Ahlert T, Sauerbrei W, Bastert G et al. Tumor cell number and viability as quality and efficacy parameters of autologous virus-modified cancer vaccines in patients with breast or ovarian cancer. J. Clin. Oncol. 15, 1354-1366 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , pp. 1354-1366
    • Ahlert, T.1    Sauerbrei, W.2    Bastert, G.3
  • 75
    • 0029022735 scopus 로고
    • Inflammatory breast cancer: 10-year follow-up trial of surgery, chemotherapy, and allogeneic tumor cell/BCG immunotherapy
    • Wiseman C. Inflammatory breast cancer: 10-year follow-up trial of surgery, chemotherapy, and allogeneic tumor cell/BCG immunotherapy. Cancer Invest. 13, 267-271 (1995).
    • (1995) Cancer Invest. , vol.13 , pp. 267-271
    • Wiseman, C.1
  • 76
    • 0037334794 scopus 로고    scopus 로고
    • Identification of tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells
    • Dols A, Meijer S, Hu H-M et al. Identification of tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells. J. Immunother. 26, 163-170 (2003).
    • (2003) J. Immunother. , vol.26 , pp. 163-170
    • Dols, A.1    Meijer, S.2    Hu, H.-M.3
  • 77
    • 0038826485 scopus 로고    scopus 로고
    • Vaccination of women with metastatic breast cancer using a costimulatory gene (CD80)-modified, HLA-A2-matched, allogeneic breast cancer cell line: Clinical and immunological results
    • Dols A, Smith J II, Meijer S et al. Vaccination of women with metastatic breast cancer using a costimulatory gene (CD80)-modified, HLA-A2-matched, allogeneic breast cancer cell line: clinical and immunological results. Human Gene Ther. 14, 1117-1123 (2003).
    • (2003) Human Gene Ther. , vol.14 , pp. 1117-1123
    • Dols, A.1    Smith II, J.2    Meijer, S.3
  • 78
    • 3242666031 scopus 로고    scopus 로고
    • Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses
    • Avigan D, Vosir B, Gong T et al. Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. Clin. Cancer Res. 10, 4699-4708 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4699-4708
    • Avigan, D.1    Vosir, B.2    Gong, T.3
  • 80
    • 0034234854 scopus 로고    scopus 로고
    • Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2
    • Klapper L, Waterman H, Sela M, Yarden Y. Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res. 60, 3384-3348 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3384-13348
    • Klapper, L.1    Waterman, H.2    Sela, M.3    Yarden, Y.4
  • 81
    • 0035126526 scopus 로고    scopus 로고
    • Accelerated HER-2 degradation enhances ovarian tumor recognition by CTL. Implications for tumor immunogenicity
    • Castilleja A, Ward N, O'Brian C et al. Accelerated HER-2 degradation enhances ovarian tumor recognition by CTL. Implications for tumor immunogenicity. Mol. Cell Biochem. 217, 21-33 (2001).
    • (2001) Mol. Cell Biochem. , vol.217 , pp. 21-33
    • Castilleja, A.1    Ward, N.2    O'Brian, C.3
  • 82
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabrilovich D, Ishida T, Nadaf S, Ohm J, Carbone D. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5, 2963-2970 (1999). First published report demonstrating the ability of vascular endothelial growth factor blockade to augment immune function.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2963-2970
    • Gabrilovich, D.1    Ishida, T.2    Nadaf, S.3    Ohm, J.4    Carbone, D.5
  • 83
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T-lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan G, Yang J, Sherry R et al. Cancer regression and autoimmunity induced by cytotoxic T-lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl. Acad. Sci. 100, 8372-8377 (2003). One of first two published reports of cytotoxic T-lymphocyte antigen (CTLA)-4 blockade in humans.
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , pp. 8372-8377
    • Phan, G.1    Yang, J.2    Sherry, R.3
  • 84
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anticytotoxic T-lymphocyte antigen-4
    • Attia P, Phan G, Maker A et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anticytotoxic T-lymphocyte antigen-4. J. Clin. Oncol. 23, 1-11 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1-11
    • Attia, P.1    Phan, G.2    Maker, A.3
  • 85
    • 20044395957 scopus 로고    scopus 로고
    • Autoimmunity in a Phase I trial of a fully human anticytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected Stages III and IV melanoma
    • Sanderson K, Scotland R, Lee P et al. Autoimmunity in a Phase I trial of a fully human anticytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected Stages III and IV melanoma. J. Clin. Oncol. 23, 741-750 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 741-750
    • Sanderson, K.1    Scotland, R.2    Lee, P.3
  • 86
    • 0034900416 scopus 로고    scopus 로고
    • The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma
    • von Mehren M, Arlen P, Gulley J et al. The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma. Clin. Cancer Res. 7, 1181-1191 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1181-1191
    • Von Mehren, M.1    Arlen, P.2    Gulley, J.3
  • 87
    • 0035152718 scopus 로고    scopus 로고
    • Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: A Phase I trial of safety and immune activation
    • Jaffee E, Hruban R, Biedrzycki B et al. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a Phase I trial of safety and immune activation. J Clin. Oncol. 19, 145-156 (2001).
    • (2001) J Clin. Oncol. , vol.19 , pp. 145-156
    • Jaffee, E.1    Hruban, R.2    Biedrzycki, B.3
  • 88
    • 3543060047 scopus 로고    scopus 로고
    • + T-cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
    • + T-cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J. Exp. Med. 200, 297-306 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 297-306
    • Thomas, A.1    Santarsiero, L.2    Lutz, E.3
  • 89
    • 0034698828 scopus 로고    scopus 로고
    • Homeostasis-stimulated proliferation drives naive T-cells to differentiate directly into memory T-cells
    • Cho B, Rao V, Ge Q, Eisen H, Chen J. Homeostasis-stimulated proliferation drives naive T-cells to differentiate directly into memory T-cells. J. Exp. Med. 192, 549-556 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 549-556
    • Cho, B.1    Rao, V.2    Ge, Q.3    Eisen, H.4    Chen, J.5
  • 90
    • 0034698931 scopus 로고    scopus 로고
    • Naive T-cells transiently aquire a memory-like phenotype during homeostasis-driven proliferation
    • Goldrath A, Bogatzki L, Bevan M. Naive T-cells transiently aquire a memory-like phenotype during homeostasis-driven proliferation. J. Exp. Med. 192, 557-564 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 557-564
    • Goldrath, A.1    Bogatzki, L.2    Bevan, M.3
  • 91
    • 0029943897 scopus 로고    scopus 로고
    • Thymic-independent T-cell regeneration occurs via antigen-driven expansion of peripheral T-cells resulting in a repertoire that is limited in diversity and prone to skewing
    • Mackall C, Bare C, Granger L et al. Thymic-independent T-cell regeneration occurs via antigen-driven expansion of peripheral T-cells resulting in a repertoire that is limited in diversity and prone to skewing. J. Immunol. 156, 4609-4616 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 4609-4616
    • Mackall, C.1    Bare, C.2    Granger, L.3
  • 92
    • 0037099515 scopus 로고    scopus 로고
    • Development of antitumor immune responses in reconstituted lymphopenic hosts
    • Hu H-M, Poehlein C, Urba W, Fox B. Development of antitumor immune responses in reconstituted lymphopenic hosts. Cancer Res. 62, 3914-3919 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 3914-3919
    • Hu, H.-M.1    Poehlein, C.2    Urba, W.3    Fox, B.4
  • 93
    • 0034658049 scopus 로고    scopus 로고
    • Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing tumor vaccines
    • Borrello I, Sotomayo E, Rattis FM et al. Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing tumor vaccines. Blood 95, 3011-3019 (2000).
    • (2000) Blood , vol.95 , pp. 3011-3019
    • Borrello, I.1    Sotomayo, E.2    Rattis, F.M.3
  • 94
    • 0035139040 scopus 로고    scopus 로고
    • Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation
    • Teshima T, Mach N, Hill G et al. Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation. Cancer Res. 61, 162-171 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 162-171
    • Teshima, T.1    Mach, N.2    Hill, G.3
  • 95
    • 1642378018 scopus 로고    scopus 로고
    • + regulatory T-cells suppress tumor immunity but are sensitive to cyclophosphamide, which allows immunotherapy of established tumors to be curative
    • + regulatory T-cells suppress tumor immunity but are sensitive to cyclophosphamide, which allows immunotherapy of established tumors to be curative. Eur. J. Immunol. 34, 336-344 (2004).
    • (2004) Eur. J. Immunol. , vol.34 , pp. 336-344
    • Ghiringhelli, F.1    Larmonier, N.2    Schmitt, E.3
  • 96
    • 15944410592 scopus 로고    scopus 로고
    • + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 105, 2862-2868 (2005).
    • (2005) Blood , vol.105 , pp. 2862-2868
    • Lutsiak, M.1    Semnani, R.2    De Pascalis, R.3
  • 97
    • 0035328683 scopus 로고    scopus 로고
    • Cyclophosphamide, doxorubicin, and paditaxel enhance the antitumor immune response of GM-CSF secreting whole-cell vaccines in HER-2/neu tolerized mice
    • Machiels JP, Reilly R, Emens L et al. Cyclophosphamide, doxorubicin, and paditaxel enhance the antitumor immune response of GM-CSF secreting whole-cell vaccines in HER-2/neu tolerized mice. Cancer Res. 61, 3689-3697 (2001). First published report of chemotherapy-modulated vaccination for cancer in a characterized model of immune tolerance.
    • (2001) Cancer Res. , vol.61 , pp. 3689-3697
    • Machiels, J.P.1    Reilly, R.2    Emens, L.3
  • 98
    • 0034653477 scopus 로고    scopus 로고
    • high T-lymphocytes in mice: Implications for strategies of chemoimmunotherapy of cancer
    • high T-lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer. Blood 95, 2024-2030 (2000).
    • (2000) Blood , vol.95 , pp. 2024-2030
    • Schiavoni, G.1    Mattei, F.2    Di Puchio, T.3
  • 99
    • 20444467321 scopus 로고    scopus 로고
    • Immunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase
    • Loeffler M, Kruger J, Reisfeld R. Immunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase. Cancer Res. 65, 5027-5030 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 5027-5030
    • Loeffler, M.1    Kruger, J.2    Reisfeld, R.3
  • 100
    • 0034723186 scopus 로고    scopus 로고
    • Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide- mimetic signal transduction by Taxol
    • Kawasaki K, Akashi S, Shimazu R et al. Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J. Biol. Chem. 275, 2251-2254 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 2251-2254
    • Kawasaki, K.1    Akashi, S.2    Shimazu, R.3
  • 101
  • 102
    • 0036037239 scopus 로고    scopus 로고
    • MyD88 is involved in the signalling pathway for Taxol-induced apoptosis and TNF-α expression in human myelomonocytic cells
    • Wang J, Kobayashi M, Han M et al. MyD88 is involved in the signalling pathway for Taxol-induced apoptosis and TNF-α expression in human myelomonocytic cells. Br. J. Hematol. 118, 638-645 (2002).
    • (2002) Br. J. Hematol. , vol.118 , pp. 638-645
    • Wang, J.1    Kobayashi, M.2    Han, M.3
  • 103
    • 0034796870 scopus 로고    scopus 로고
    • Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paditaxel chemotherapy
    • Demaria S, Volm M, Shapiro R et al. Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paditaxel chemotherapy. Clin Cancer Res. 7, 3025-3303 (2001).
    • (2001) Clin Cancer Res. , vol.7 , pp. 3025-3303
    • Demaria, S.1    Volm, M.2    Shapiro, R.3
  • 104
    • 0031975265 scopus 로고    scopus 로고
    • Immunomodulatory properties of antineoplastic drugs administered in conjunction with GM-CSF-secreting cancer cell vaccines
    • Nigam A, Yacavone R, Zahurak M et al. Immunomodulatory properties of antineoplastic drugs administered in conjunction with GM-CSF-secreting cancer cell vaccines. Int. J. Cancer 12, 161-170 (1998). First published report of chemotherapy-modulated vaccination for cancer.
    • (1998) Int. J. Cancer , vol.12 , pp. 161-170
    • Nigam, A.1    Yacavone, R.2    Zahurak, M.3
  • 105
    • 7044231363 scopus 로고    scopus 로고
    • Doxorubicin and paditaxel enhance the antitumor efficacy of vaccines directed against HER-2/neu in a murine mammary carcinoma model
    • Eralp Y, Wang X, Wang J et al. Doxorubicin and paditaxel enhance the antitumor efficacy of vaccines directed against HER-2/neu in a murine mammary carcinoma model. Breast Cancer Res. 6, R275-R283 (2004).
    • (2004) Breast Cancer Res. , vol.6
    • Eralp, Y.1    Wang, X.2    Wang, J.3
  • 106
    • 0037239826 scopus 로고    scopus 로고
    • Effective combination of chemotherapy and dendritic cell administration for the treatment of advanced-stage experimental cancer
    • Yu B, Kusmartsev S, Cheng F et al. Effective combination of chemotherapy and dendritic cell administration for the treatment of advanced-stage experimental cancer. Clin. Cancer Res. 9, 285-294 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 285-294
    • Yu, B.1    Kusmartsev, S.2    Cheng, F.3
  • 107
    • 0026472124 scopus 로고
    • Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    • Guy C, Webster M, Schaller M et al. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc. Natl. Acad. Sci. 89, 10578-10582 (1992).
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 10578-10582
    • Guy, C.1    Webster, M.2    Schaller, M.3
  • 108
    • 0034234934 scopus 로고    scopus 로고
    • HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice
    • Reilly R, Gottlieb M, Ercolini A et al. HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice. Cancer Res. 60, 3569-3576 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3569-3576
    • Reilly, R.1    Gottlieb, M.2    Ercolini, A.3
  • 109
    • 0037446542 scopus 로고    scopus 로고
    • Identification and characterization of the immunodominant rat HER-2/neu MHC Class I epitope presented by spontaneous mammary tumors from HER-2/neu transgenic mice
    • Ercolini A, Machiels J-P, Chen Y et al. Identification and characterization of the immunodominant rat HER-2/neu MHC Class I epitope presented by spontaneous mammary tumors from HER-2/neu transgenic mice. J. Immunol. 170, 4273-4280 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 4273-4280
    • Ercolini, A.1    Machiels, J.-P.2    Chen, Y.3
  • 110
    • 12144287913 scopus 로고    scopus 로고
    • A Phase I vaccine safety and chemotherapy dose-finding trial of an allogeneic GM-CSF-secreting breast cancer vaccine given in a specifically timed sequence with immunomodulatory doses of cyclophosphamide and doxorubicin
    • Emens L, Armstrong D, Biedrzycki B et al. A Phase I vaccine safety and chemotherapy dose-finding trial of an allogeneic GM-CSF-secreting breast cancer vaccine given in a specifically timed sequence with immunomodulatory doses of cyclophosphamide and doxorubicin. Human Gene Ther. 15, 313-337 (2004).
    • (2004) Human Gene Ther. , vol.15 , pp. 313-337
    • Emens, L.1    Armstrong, D.2    Biedrzycki, B.3
  • 111
    • 0043136619 scopus 로고    scopus 로고
    • + T-cell effector function and tumor-free survival in HER-2/neu transgenic mice
    • + T-cell effector function and tumor-free survival in HER-2/neu transgenic mice. J. Immunol. 15, 2161-2169 (2003). Demonstrates enhanced antigen-specific immune responses with combined monoclonal antibody and vaccine therapy.
    • (2003) J. Immunol. , vol.15 , pp. 2161-2169
    • Wolpoe, M.1    Lutz, E.2    Ercolini, A.3
  • 112
    • 0032544067 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    • Hurwitz A, Yu T, Leach D, Allison J. CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc. Natl. Acad. Sci. 18, 10067-10071 (1998).
    • (1998) Proc. Natl. Acad. Sci. , vol.18 , pp. 10067-10071
    • Hurwitz, A.1    Yu, T.2    Leach, D.3    Allison, J.4
  • 113
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anticytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • van Elsas A, Hurwitz A, Allison J. Combination immunotherapy of B16 melanoma using anticytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J. Exp. Med. 190, 355-366 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 355-366
    • Van Elsas, A.1    Hurwitz, A.2    Allison, J.3
  • 114
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T-lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • Hodi F, Mihm M, Soiffer R et al. Biologic activity of cytotoxic T-lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl. Acad. Sci. 100, 4712-4717 (2003). One of first two published reports of CTLA-4 blockade in humans.
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , pp. 4712-4717
    • Hodi, F.1    Mihm, M.2    Soiffer, R.3
  • 115
    • 2942592429 scopus 로고    scopus 로고
    • Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
    • Sugamura K, Ishii N, Weinberg A. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nature Rev. Immunol. 4, 420-431 (2004). A comprehensive review of OX40 biology.
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 420-431
    • Sugamura, K.1    Ishii, N.2    Weinberg, A.3
  • 116
    • 0034904266 scopus 로고    scopus 로고
    • Induction of antimammary cancer immunity by engaging OX-40 receptor in vivo
    • Morris A, Vetto J, Ramstad R et al. Induction of antimammary cancer immunity by engaging OX-40 receptor in vivo. Breast Cancer Res. Treat 67, 71-80 (2001).
    • (2001) Breast Cancer Res. Treat , vol.67 , pp. 71-80
    • Morris, A.1    Vetto, J.2    Ramstad, R.3
  • 117
    • 0036799040 scopus 로고    scopus 로고
    • OX40 ligation enhances primary and memory cytotoxic T-lymphocyte responses in an immunotherapy for hepatic colon metastases
    • Pan P, Zang Y, Weber K, Meseck M, Chen S. OX40 ligation enhances primary and memory cytotoxic T-lymphocyte responses in an immunotherapy for hepatic colon metastases. Mol. Ther. 6, 528-536 (2002).
    • (2002) Mol. Ther. , vol.6 , pp. 528-536
    • Pan, P.1    Zang, Y.2    Weber, K.3    Meseck, M.4    Chen, S.5
  • 118
    • 0037218624 scopus 로고    scopus 로고
    • OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-APC signaling to boost the host T-cell antitumor response
    • Gri G, Gallo E, Di Carlo E, Musiani P, Colombo M. OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-APC signaling to boost the host T-cell antitumor response. J. Immunol. 170, 99-106 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 99-106
    • Gri, G.1    Gallo, E.2    Di Carlo, E.3    Musiani, P.4    Colombo, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.