-
1
-
-
0034617178
-
Aspartate 351 of estrogen receptor alpha is not crucial for the antagonist activity of antiestrogens
-
Anghel SI, Perly V, Melancon G, Barsalou A, Chagnon S, Rosenauer A, Miller WH Jr & Mader S 2000 Aspartate 351 of estrogen receptor alpha is not crucial for the antagonist activity of antiestrogens. Journal of Biological Chemistry 275 20867-20872.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 20867-20872
-
-
Anghel, S.I.1
Perly, V.2
Melancon, G.3
Barsalou, A.4
Chagnon, S.5
Rosenauer, A.6
Miller Jr., W.H.7
Mader, S.8
-
2
-
-
0030797902
-
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
-
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM & Meltzer PS 1997 AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277 965-968.
-
(1997)
Science
, vol.277
, pp. 965-968
-
-
Anzick, S.L.1
Kononen, J.2
Walker, R.L.3
Azorsa, D.O.4
Tanner, M.M.5
Guan, X.Y.6
Sauter, G.7
Kallioniemi, O.P.8
Trent, J.M.9
Meltzer, P.S.10
-
3
-
-
0242290172
-
Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor
-
Benko S, Love JD, Beladi M, Schwabe JW & Nagy L 2003 Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor. Journal of Biological Chemistry 278 43797-43806.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 43797-43806
-
-
Benko, S.1
Love, J.D.2
Beladi, M.3
Schwabe, J.W.4
Nagy, L.5
-
4
-
-
0029012163
-
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha
-
Bourguet W, Ruff M, Chambon P, Gronemeyer H & Moras D 1995 Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature 375 377-382.
-
(1995)
Nature
, vol.375
, pp. 377-382
-
-
Bourguet, W.1
Ruff, M.2
Chambon, P.3
Gronemeyer, H.4
Moras, D.5
-
5
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Ohman L, Greene GL, Gustafsson JA & Carlquist M 1997 Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389 753-758.
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
Pike, A.C.2
Dauter, Z.3
Hubbard, R.E.4
Bonn, T.5
Engstrom, O.6
Ohman, L.7
Greene, G.L.8
Gustafsson, J.A.9
Carlquist, M.10
-
6
-
-
0030734795
-
Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: Evidence that an open pocket conformation is required for ligand interaction
-
Carlson KE, Choi I, Gee A, Katzenellenbogen BS & Katzenellenbogen JA 1997 Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction. Biochemistry 36 14897-14905.
-
(1997)
Biochemistry
, vol.36
, pp. 14897-14905
-
-
Carlson, K.E.1
Choi, I.2
Gee, A.3
Katzenellenbogen, B.S.4
Katzenellenbogen, J.A.5
-
7
-
-
0032213219
-
Structure and specificity of nuclear receptor-coactivator interactions
-
Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ & Yamamoto KR 1998 Structure and specificity of nuclear receptor-coactivator interactions. Genes and Development 12 3343-3356.
-
(1998)
Genes and Development
, vol.12
, pp. 3343-3356
-
-
Darimont, B.D.1
Wagner, R.L.2
Apriletti, J.W.3
Stallcup, M.R.4
Kushner, P.J.5
Baxter, J.D.6
Fletterick, R.J.7
Yamamoto, K.R.8
-
8
-
-
0036187372
-
Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3
-
Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dorsselaer A, Moras D & Renaud JP 2002 Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. Molecular Cell 9 303-313.
-
(2002)
Molecular Cell
, vol.9
, pp. 303-313
-
-
Greschik, H.1
Wurtz, J.M.2
Sanglier, S.3
Bourguet, W.4
van Dorsselaer, A.5
Moras, D.6
Renaud, J.P.7
-
9
-
-
0035813112
-
The multifaceted mechanisms of estradiol and estrogen receptor signaling
-
Hall JM, Couse JF & Korach KS 2001 The multifaceted mechanisms of estradiol and estrogen receptor signaling. Journal of Biological Chemistry 276 36869-36872.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 36869-36872
-
-
Hall, J.M.1
Couse, J.F.2
Korach, K.S.3
-
10
-
-
0030986236
-
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
-
Heery DM, Kalkhoven E, Hoare S & Parker MG 1997 A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387 733-736.
-
(1997)
Nature
, vol.387
, pp. 733-736
-
-
Heery, D.M.1
Kalkhoven, E.2
Hoare, S.3
Parker, M.G.4
-
11
-
-
0030950531
-
AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors
-
Henttu PM, Kalkhoven E & Parker MG 1997 AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors. Molecular and Cellular Biology 17 1832-1839.
-
(1997)
Molecular and Cellular Biology
, vol.17
, pp. 1832-1839
-
-
Henttu, P.M.1
Kalkhoven, E.2
Parker, M.G.3
-
12
-
-
0030949836
-
GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
-
Hong H, Kohli K, Garabedian MJ & Stallcup MR 1997 GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Molecular and Cellular Biology 17 2735-2744.
-
(1997)
Molecular and Cellular Biology
, vol.17
, pp. 2735-2744
-
-
Hong, H.1
Kohli, K.2
Garabedian, M.J.3
Stallcup, M.R.4
-
13
-
-
0033529498
-
Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3
-
Hong H, Yang L & Stallcup MR 1999 Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. Journal of Biological Chemistry 274 22618-22626.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 22618-22626
-
-
Hong, H.1
Yang, L.2
Stallcup, M.R.3
-
14
-
-
0033753609
-
Faslodex (ICI 182780): An oestrogen receptor downregulator
-
Howell A 2000 Faslodex (ICI 182780): an oestrogen receptor downregulator. European Journal of Cancer 36 (Suppl 4) S87-S88.
-
(2000)
European Journal of Cancer
, vol.36
, Issue.SUPPL. 4
-
-
Howell, A.1
-
15
-
-
0033304703
-
Tamoxifen, raloxifene, and the prevention of breast cancer
-
Jordan VC & Morrow M 1999 Tamoxifen, raloxifene, and the prevention of breast cancer. Endocrine Reviews 20 253-278.
-
(1999)
Endocrine Reviews
, vol.20
, pp. 253-278
-
-
Jordan, V.C.1
Morrow, M.2
-
17
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E, Kawashima H et al. 1995 Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270 1491-1494.
-
(1995)
Science
, vol.270
, pp. 1491-1494
-
-
Kato, S.1
Endoh, H.2
Masuhiro, Y.3
Kitamoto, T.4
Uchiyama, S.5
Sasaki, H.6
Masushige, S.7
Gotoh, Y.8
Nishida, E.9
Kawashima, H.10
-
18
-
-
0348047596
-
CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators
-
Kim JH, Li H & Stallcup MR 2003 CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Molecular Cell 12 1537-1549.
-
(2003)
Molecular Cell
, vol.12
, pp. 1537-1549
-
-
Kim, J.H.1
Li, H.2
Stallcup, M.R.3
-
19
-
-
0030579801
-
Cloning of a novel receptor expressed in rat prostate and ovary
-
Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S & Gustafsson JA 1996 Cloning of a novel receptor expressed in rat prostate and ovary. PNAS 93 5925-5930.
-
(1996)
PNAS
, vol.93
, pp. 5925-5930
-
-
Kuiper, G.G.1
Enmark, E.2
Pelto-Huikko, M.3
Nilsson, S.4
Gustafsson, J.A.5
-
20
-
-
0031473542
-
Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: Correlations with DNA and coregulator interactions and receptor conformational changes
-
Lazennec G, Ediger TR, Petz LN, Nardulli AM & Katzenellenbogen BS 1997 Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: correlations with DNA and coregulator interactions and receptor conformational changes. Molecular Endocrinology 11 1375-1386.
-
(1997)
Molecular Endocrinology
, vol.11
, pp. 1375-1386
-
-
Lazennec, G.1
Ediger, T.R.2
Petz, L.N.3
Nardulli, A.M.4
Katzenellenbogen, B.S.5
-
21
-
-
2642593030
-
The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor
-
Levenson AS & Jordan VC 1998 The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor. Cancer Research 58 1872-1875.
-
(1998)
Cancer Research
, vol.58
, pp. 1872-1875
-
-
Levenson, A.S.1
Jordan, V.C.2
-
22
-
-
0034989904
-
Control of the estrogen-like actions of the tamoxifen-estrogen receptor complex by the surface amino acid at position 351
-
Levenson AS, MacGregor Schafer JI, Bentrem DJ, Pease KM & Jordan VC 2001 Control of the estrogen-like actions of the tamoxifen-estrogen receptor complex by the surface amino acid at position 351. Journal of Steroid Biochemistry and Molecular Biology 76 61-70.
-
(2001)
Journal of Steroid Biochemistry and Molecular Biology
, vol.76
, pp. 61-70
-
-
Levenson, A.S.1
MacGregor Schafer, J.I.2
Bentrem, D.J.3
Pease, K.M.4
Jordan, V.C.5
-
23
-
-
0037088656
-
Structure-function relationships of the raloxifene-estrogen receptor-alpha complex for regulating transforming growth factor-alpha expression in breast cancer cells
-
Liu H, Park WC, Bentrem DJ, McKian KP, Reyes Ade L, Loweth JA, Schafer JM, Zapf JW & Jordan VC 2002 Structure-function relationships of the raloxifene-estrogen receptor-alpha complex for regulating transforming growth factor-alpha expression in breast cancer cells. Journal of Biological Chemistry 277 9189-9198.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 9189-9198
-
-
Liu, H.1
Park, W.C.2
Bentrem, D.J.3
McKian, K.P.4
Reyes Ade, L.5
Loweth, J.A.6
Schafer, J.M.7
Zapf, J.W.8
Jordan, V.C.9
-
24
-
-
0032766843
-
Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins
-
Ma H, Hong H, Huang SM, Irvine RA, Webb P, Kushner PJ, Coetzee GA & Stallcup MR 1999 Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins. Molecular and Cellular Biology 19 6164-6173.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 6164-6173
-
-
Ma, H.1
Hong, H.2
Huang, S.M.3
Irvine, R.A.4
Webb, P.5
Kushner, P.J.6
Coetzee, G.A.7
Stallcup, M.R.8
-
26
-
-
0031833450
-
The nuclear receptor ligand-binding domain: Structure and function
-
Moras D & Gronemeyer H 1998 The nuclear receptor ligand-binding domain: structure and function. Current Opinion in Cell Biology 10 384-391.
-
(1998)
Current Opinion in Cell Biology
, vol.10
, pp. 384-391
-
-
Moras, D.1
Gronemeyer, H.2
-
27
-
-
15544371000
-
Ligand control of coregulator recruitment to nuclear receptors
-
Nettles KW & Greene GL 2005 Ligand control of coregulator recruitment to nuclear receptors. Annual Review of Physiology 67 309-333.
-
(2005)
Annual Review of Physiology
, vol.67
, pp. 309-333
-
-
Nettles, K.W.1
Greene, G.L.2
-
28
-
-
0028846193
-
Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
-
Onate SA, Tsai SY, Tsai MJ & O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270 1354-1357.
-
(1995)
Science
, vol.270
, pp. 1354-1357
-
-
Onate, S.A.1
Tsai, S.Y.2
Tsai, M.J.3
O'Malley, B.W.4
-
29
-
-
0033855713
-
Selective estrogen receptor modulators: Structure, function, and clinical use
-
Osborne CK, Zhao H & Fuqua SA 2000 Selective estrogen receptor modulators: structure, function, and clinical use. Journal of Clinical Oncology 18 3172-3186.
-
(2000)
Journal of Clinical Oncology
, vol.18
, pp. 3172-3186
-
-
Osborne, C.K.1
Zhao, H.2
Fuqua, S.A.3
-
31
-
-
0033198735
-
Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
-
Pike AC, Brzozowski AM, Hubbard RE, Bonn T, Thorsell AG, Engstrom O, Ljunggren J, Gustafsson JA & Carlquist M 1999 Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO Journal 18 4608-4618.
-
(1999)
EMBO Journal
, vol.18
, pp. 4608-4618
-
-
Pike, A.C.1
Brzozowski, A.M.2
Hubbard, R.E.3
Bonn, T.4
Thorsell, A.G.5
Engstrom, O.6
Ljunggren, J.7
Gustafsson, J.A.8
Carlquist, M.9
-
33
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA & Greene GL 1998 The structural basis of estrogen receptor /coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95 927-937.
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
Cheng, L.4
Kushner, P.J.5
Agard, D.A.6
Greene, G.L.7
-
34
-
-
0033083820
-
Coexpression of estrogen receptor alpha and beta: Poor prognostic factors in human breast cancer?
-
Speirs V, Parkes AT, Kerin MJ, Walton DS, Carleton PJ, Fox JN & Atkin SL 1999 Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer? Cancer Research 59 525-528.
-
(1999)
Cancer Research
, vol.59
, pp. 525-528
-
-
Speirs, V.1
Parkes, A.T.2
Kerin, M.J.3
Walton, D.S.4
Carleton, P.J.5
Fox, J.N.6
Atkin, S.L.7
-
35
-
-
0032031082
-
Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens
-
Tremblay G, Tremblay A, Labrie F & Giguere V 1998 Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens. Cancer Research 58 877-881.
-
(1998)
Cancer Research
, vol.58
, pp. 877-881
-
-
Tremblay, G.1
Tremblay, A.2
Labrie, F.3
Giguere, V.4
-
36
-
-
0028283503
-
Molecular mechanisms of action of steroid/thyroid receptor superfamily members
-
Tsai MJ & O'Malley BW 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annual Review of Biochemistry 63 451-486.
-
(1994)
Annual Review of Biochemistry
, vol.63
, pp. 451-486
-
-
Tsai, M.J.1
O'Malley, B.W.2
-
37
-
-
0034532014
-
An antiestrogen-responsive estrogen receptor-alpha mutant (D351Y) shows weak AF-2 activity in the presence of tamoxifen
-
Webb P, Nguyen P, Valentine C, Weatherman RV, Scanlan TS & Kushner PJ 2000 An antiestrogen-responsive estrogen receptor-alpha mutant (D351Y) shows weak AF-2 activity in the presence of tamoxifen. Journal of Biological Chemistry 275 37552-37558.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 37552-37558
-
-
Webb, P.1
Nguyen, P.2
Valentine, C.3
Weatherman, R.V.4
Scanlan, T.S.5
Kushner, P.J.6
-
38
-
-
0030445855
-
Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein
-
Weis KE, Ekena K, Thomas JA, Lazennec G & Katzenellenbogen BS 1996 Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein. Molecular Endocrinology 10 1388-1398.
-
(1996)
Molecular Endocrinology
, vol.10
, pp. 1388-1398
-
-
Weis, K.E.1
Ekena, K.2
Thomas, J.A.3
Lazennec, G.4
Katzenellenbogen, B.S.5
-
39
-
-
0342547258
-
Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine
-
White R, Sjoberg M, Kalkhoven E & Parker MG 1997 Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine. EMBO Journal 16 1427-1435.
-
(1997)
EMBO Journal
, vol.16
, pp. 1427-1435
-
-
White, R.1
Sjoberg, M.2
Kalkhoven, E.3
Parker, M.G.4
-
40
-
-
0030741983
-
Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone
-
Willson TM, Norris JD, Wagner BL, Asplin I, Baer P, Brown HR, Jones SA, Henke B, Sauls H, Wolfe S et al. 1997 Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. Endocrinology 138 3901-3911.
-
(1997)
Endocrinology
, vol.138
, pp. 3901-3911
-
-
Willson, T.M.1
Norris, J.D.2
Wagner, B.L.3
Asplin, I.4
Baer, P.5
Brown, H.R.6
Jones, S.A.7
Henke, B.8
Sauls, H.9
Wolfe, S.10
-
41
-
-
0028093565
-
The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain
-
Wolf DM & Jordan VC 1994 The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain. Breast Cancer Research and Treatment 31 129-138.
-
(1994)
Breast Cancer Research and Treatment
, vol.31
, pp. 129-138
-
-
Wolf, D.M.1
Jordan, V.C.2
-
42
-
-
18944381947
-
Structural basis for an unexpected mode of SERM-mediated ER antagonism
-
Wu YL, Yang X, Ren Z, McDonnell DP, Norris JD, Willson TM & Greene GL 2005 Structural basis for an unexpected mode of SERM-mediated ER antagonism. Molecular Cell 18 413-424.
-
(2005)
Molecular Cell
, vol.18
, pp. 413-424
-
-
Wu, Y.L.1
Yang, X.2
Ren, Z.3
McDonnell, D.P.4
Norris, J.D.5
Willson, T.M.6
Greene, G.L.7
-
43
-
-
0030056997
-
A canonical structure for the ligand-binding domain of nuclear receptors
-
Wurtz JM, Bourguet W, Renaud JP, Vivat V, Chambon P, Moras D & Gronemeyer H 1996 A canonical structure for the ligand-binding domain of nuclear receptors. Nature Structural Biology 3 87-94.
-
(1996)
Nature Structural Biology
, vol.3
, pp. 87-94
-
-
Wurtz, J.M.1
Bourguet, W.2
Renaud, J.P.3
Vivat, V.4
Chambon, P.5
Moras, D.6
Gronemeyer, H.7
-
44
-
-
0035900785
-
The tamoxifen-responsive estrogen receptor alpha mutant D351Y shows reduced tamoxifen-dependent interaction with corepressor complexes
-
Yamamoto Y, Wada O, Suzawa M, Yogiashi Y, Yano T, Kato S & Yanagisawa J 2001 The tamoxifen-responsive estrogen receptor alpha mutant D351Y shows reduced tamoxifen-dependent interaction with corepressor complexes. Journal of Biological Chemistry 276 42684-42691.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 42684-42691
-
-
Yamamoto, Y.1
Wada, O.2
Suzawa, M.3
Yogiashi, Y.4
Yano, T.5
Kato, S.6
Yanagisawa, J.7
-
45
-
-
0030940071
-
An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer
-
Zhang QX, Borg A, Wolf DM, Oesterreich S & Fuqua SA 1997 An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer. Cancer Research 57 1244-1249.
-
(1997)
Cancer Research
, vol.57
, pp. 1244-1249
-
-
Zhang, Q.X.1
Borg, A.2
Wolf, D.M.3
Oesterreich, S.4
Fuqua, S.A.5
|