Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes

Toxicological Sciences

Volumn 79, Issue 2, 2004, Pages 248-257

  Trouba, K J ^a   Germolec, D R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Arsenic; Cyclooxygenase; MAP kinase; PD98059; SB202190

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLSALICYLIC ACID; ARSENITE SODIUM; CYCLOOXYGENASE 2; DNA; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PIROXICAM; PROSTAGLANDIN E2; PROTEIN P42; PROTEIN P44;

ARTICLE; ATTENUATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EPIDERMIS CELL; EVIDENCE BASED MEDICINE; HUMAN; HUMAN CELL; KERATINOCYTE; MODULATION; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN CARCINOGENESIS; SKIN INFLAMMATION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ARSENITES; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KERATINOCYTES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SODIUM COMPOUNDS;

EID: 2942739376     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh132     Document Type: Article

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